Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology

Loss of function GIMAP5 mutation is associated with lymphopenia, but how it mediates T cell homeostasis is unclear. Here the authors study Gimap5−/− mice and a patient with GIMAP5 deficiency to show how this GTPAse negatively regulates GSK3β activity to prevent DNA damage and cell death.

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Autores principales:	Andrew R. Patterson, Mehari Endale, Kristin Lampe, Halil I. Aksoylar, Aron Flagg, Jim R. Woodgett, David Hildeman, Michael B. Jordan, Harinder Singh, Zeynep Kucuk, Jack Bleesing, Kasper Hoebe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/09487aa202ff4465abb8756803164dd9
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spelling	oai:doaj.org-article:09487aa202ff4465abb8756803164dd92021-12-02T16:49:39ZGimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology10.1038/s41467-018-02897-72041-1723https://doaj.org/article/09487aa202ff4465abb8756803164dd92018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02897-7https://doaj.org/toc/2041-1723Loss of function GIMAP5 mutation is associated with lymphopenia, but how it mediates T cell homeostasis is unclear. Here the authors study Gimap5−/− mice and a patient with GIMAP5 deficiency to show how this GTPAse negatively regulates GSK3β activity to prevent DNA damage and cell death.Andrew R. PattersonMehari EndaleKristin LampeHalil I. AksoylarAron FlaggJim R. WoodgettDavid HildemanMichael B. JordanHarinder SinghZeynep KucukJack BleesingKasper HoebeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew R. Patterson Mehari Endale Kristin Lampe Halil I. Aksoylar Aron Flagg Jim R. Woodgett David Hildeman Michael B. Jordan Harinder Singh Zeynep Kucuk Jack Bleesing Kasper Hoebe Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology
description	Loss of function GIMAP5 mutation is associated with lymphopenia, but how it mediates T cell homeostasis is unclear. Here the authors study Gimap5−/− mice and a patient with GIMAP5 deficiency to show how this GTPAse negatively regulates GSK3β activity to prevent DNA damage and cell death.
format	article
author	Andrew R. Patterson Mehari Endale Kristin Lampe Halil I. Aksoylar Aron Flagg Jim R. Woodgett David Hildeman Michael B. Jordan Harinder Singh Zeynep Kucuk Jack Bleesing Kasper Hoebe
author_facet	Andrew R. Patterson Mehari Endale Kristin Lampe Halil I. Aksoylar Aron Flagg Jim R. Woodgett David Hildeman Michael B. Jordan Harinder Singh Zeynep Kucuk Jack Bleesing Kasper Hoebe
author_sort	Andrew R. Patterson
title	Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology
title_short	Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology
title_full	Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology
title_fullStr	Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology
title_full_unstemmed	Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology
title_sort	gimap5-dependent inactivation of gsk3β is required for cd4+ t cell homeostasis and prevention of immune pathology
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/09487aa202ff4465abb8756803164dd9
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Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology

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