The role of sleep in bipolar disorder

Alexandra K Gold,1 Louisa G Sylvia,1,2 1Department of Psychiatry, Massachusetts General Hospital, 2Harvard Medical School, Boston, MA, USA Abstract: Bipolar disorder is a serious mental illness characterized by alternating periods of elevated and depressed mood. Sleep disturbances in bipolar disorde...

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Autores principales:	Gold AK, Sylvia LG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	bipolar disorder circadian rhythms sleep-wake homeostasis Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/0948c78bb5764143b2079df676eb5d23
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spelling	oai:doaj.org-article:0948c78bb5764143b2079df676eb5d232021-12-02T00:19:58ZThe role of sleep in bipolar disorder1179-1608https://doaj.org/article/0948c78bb5764143b2079df676eb5d232016-06-01T00:00:00Zhttps://www.dovepress.com/the-role-of-sleep-in-bipolar-disorder-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Alexandra K Gold,1 Louisa G Sylvia,1,2 1Department of Psychiatry, Massachusetts General Hospital, 2Harvard Medical School, Boston, MA, USA Abstract: Bipolar disorder is a serious mental illness characterized by alternating periods of elevated and depressed mood. Sleep disturbances in bipolar disorder are present during all stages of the condition and exert a negative impact on overall course, quality of life, and treatment outcomes. We examine the partnership between circadian system (process C) functioning and sleep–wake homeostasis (process S) on optimal sleep functioning and explore the role of disruptions in both systems on sleep disturbances in bipolar disorder. A convergence of evidence suggests that sleep problems in bipolar disorder result from dysregulation across both process C and process S systems. Biomarkers of depressive episodes include heightened fragmentation of rapid eye movement (REM) sleep, reduced REM latency, increased REM density, and a greater percentage of awakenings, while biomarkers of manic episodes include reduced REM latency, greater percentage of stage I sleep, increased REM density, discontinuous sleep patterns, shortened total sleep time, and a greater time awake in bed. These findings highlight the importance of targeting novel treatments for sleep disturbance in bipolar disorder. Keywords: bipolar disorder, circadian rhythms, sleep–wake homeostasisGold AKSylvia LGDove Medical Pressarticlebipolar disordercircadian rhythmssleep-wake homeostasisPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2016, Iss Issue 1, Pp 207-214 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	bipolar disorder circadian rhythms sleep-wake homeostasis Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	bipolar disorder circadian rhythms sleep-wake homeostasis Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Gold AK Sylvia LG The role of sleep in bipolar disorder
description	Alexandra K Gold,1 Louisa G Sylvia,1,2 1Department of Psychiatry, Massachusetts General Hospital, 2Harvard Medical School, Boston, MA, USA Abstract: Bipolar disorder is a serious mental illness characterized by alternating periods of elevated and depressed mood. Sleep disturbances in bipolar disorder are present during all stages of the condition and exert a negative impact on overall course, quality of life, and treatment outcomes. We examine the partnership between circadian system (process C) functioning and sleep–wake homeostasis (process S) on optimal sleep functioning and explore the role of disruptions in both systems on sleep disturbances in bipolar disorder. A convergence of evidence suggests that sleep problems in bipolar disorder result from dysregulation across both process C and process S systems. Biomarkers of depressive episodes include heightened fragmentation of rapid eye movement (REM) sleep, reduced REM latency, increased REM density, and a greater percentage of awakenings, while biomarkers of manic episodes include reduced REM latency, greater percentage of stage I sleep, increased REM density, discontinuous sleep patterns, shortened total sleep time, and a greater time awake in bed. These findings highlight the importance of targeting novel treatments for sleep disturbance in bipolar disorder. Keywords: bipolar disorder, circadian rhythms, sleep–wake homeostasis
format	article
author	Gold AK Sylvia LG
author_facet	Gold AK Sylvia LG
author_sort	Gold AK
title	The role of sleep in bipolar disorder
title_short	The role of sleep in bipolar disorder
title_full	The role of sleep in bipolar disorder
title_fullStr	The role of sleep in bipolar disorder
title_full_unstemmed	The role of sleep in bipolar disorder
title_sort	role of sleep in bipolar disorder
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/0948c78bb5764143b2079df676eb5d23
work_keys_str_mv	AT goldak theroleofsleepinbipolardisorder AT sylvialg theroleofsleepinbipolardisorder AT goldak roleofsleepinbipolardisorder AT sylvialg roleofsleepinbipolardisorder
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The role of sleep in bipolar disorder

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