Drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour

Drug addiction is partially heritable but the non-genetic inheritance mechanisms are not well understood. The authors show that motivation of male rats in response to cocaine self-administration elicit susceptibility and/or decreased resistance to developing addiction like behaviour in offspring.

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Detalles Bibliográficos
Autores principales: Qiumin Le, Biao Yan, Xiangchen Yu, Yanqing Li, Haikun Song, Huiwen Zhu, Weiqing Hou, Dingailu Ma, Feizhen Wu, Yuqing Zhou, Lan Ma
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/094c1b7ec7124386ad183697cf2ffd00
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Sumario:Drug addiction is partially heritable but the non-genetic inheritance mechanisms are not well understood. The authors show that motivation of male rats in response to cocaine self-administration elicit susceptibility and/or decreased resistance to developing addiction like behaviour in offspring.