Drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour

Drug addiction is partially heritable but the non-genetic inheritance mechanisms are not well understood. The authors show that motivation of male rats in response to cocaine self-administration elicit susceptibility and/or decreased resistance to developing addiction like behaviour in offspring.

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Autores principales: Qiumin Le, Biao Yan, Xiangchen Yu, Yanqing Li, Haikun Song, Huiwen Zhu, Weiqing Hou, Dingailu Ma, Feizhen Wu, Yuqing Zhou, Lan Ma
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/094c1b7ec7124386ad183697cf2ffd00
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spelling oai:doaj.org-article:094c1b7ec7124386ad183697cf2ffd002021-12-02T14:42:18ZDrug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour10.1038/ncomms155272041-1723https://doaj.org/article/094c1b7ec7124386ad183697cf2ffd002017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15527https://doaj.org/toc/2041-1723Drug addiction is partially heritable but the non-genetic inheritance mechanisms are not well understood. The authors show that motivation of male rats in response to cocaine self-administration elicit susceptibility and/or decreased resistance to developing addiction like behaviour in offspring.Qiumin LeBiao YanXiangchen YuYanqing LiHaikun SongHuiwen ZhuWeiqing HouDingailu MaFeizhen WuYuqing ZhouLan MaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Qiumin Le
Biao Yan
Xiangchen Yu
Yanqing Li
Haikun Song
Huiwen Zhu
Weiqing Hou
Dingailu Ma
Feizhen Wu
Yuqing Zhou
Lan Ma
Drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour
description Drug addiction is partially heritable but the non-genetic inheritance mechanisms are not well understood. The authors show that motivation of male rats in response to cocaine self-administration elicit susceptibility and/or decreased resistance to developing addiction like behaviour in offspring.
format article
author Qiumin Le
Biao Yan
Xiangchen Yu
Yanqing Li
Haikun Song
Huiwen Zhu
Weiqing Hou
Dingailu Ma
Feizhen Wu
Yuqing Zhou
Lan Ma
author_facet Qiumin Le
Biao Yan
Xiangchen Yu
Yanqing Li
Haikun Song
Huiwen Zhu
Weiqing Hou
Dingailu Ma
Feizhen Wu
Yuqing Zhou
Lan Ma
author_sort Qiumin Le
title Drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour
title_short Drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour
title_full Drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour
title_fullStr Drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour
title_full_unstemmed Drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour
title_sort drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/094c1b7ec7124386ad183697cf2ffd00
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