Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells

Zhijie Ding,1,* Marion Joy,1,* Marina V Kameneva,1-3 Partha Roy1,3-6 1Department of Bioengineering, 2Department of Surgery, 3McGowan Institute of Regenerative Medicine, 4Department of Pathology, 5Department of Cell Biology, 6Magee Women&rsquo...

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Autores principales:	Ding Z, Joy M, Kameneva MV, Roy P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Breast cancer metastasis extravasation hemodynamics drag reducing polymer blood cell traffic Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/094edc5f4c6146c1811dd2cee137131a
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spelling	oai:doaj.org-article:094edc5f4c6146c1811dd2cee137131a2021-12-02T06:13:28ZNanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells1179-1314https://doaj.org/article/094edc5f4c6146c1811dd2cee137131a2017-02-01T00:00:00Zhttps://www.dovepress.com/nanomolar-concentration-of-blood-soluble-drag-reducing-polymer-inhibit-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Zhijie Ding,1,* Marion Joy,1,* Marina V Kameneva,1-3 Partha Roy1,3-6 1Department of Bioengineering, 2Department of Surgery, 3McGowan Institute of Regenerative Medicine, 4Department of Pathology, 5Department of Cell Biology, 6Magee Women’s Research Institute, University of Pittsburgh, Pittsburgh, PA, USA *These authors contributed equally to this work Abstract: Metastasis is the leading cause of cancer mortality. Extravasation of cancer cells is a critical step of metastasis. We report a novel proof-of-concept study that investigated whether non-toxic blood-soluble chemical agents capable of rheological modification of the near-vessel-wall blood flow can reduce extravasation of tumor cells and subsequent development of metastasis. Using an experimental metastasis model, we demonstrated that systemic administration of nanomolar concentrations of so-called drag-reducing polymer dramatically impeded extravasation and development of pulmonary metastasis of breast cancer cells in mice. This is the first proof-of-principle study to directly demonstrate physical/rheological, as opposed to chemical, way to prevent cancer cells from extravasation and developing metastasis and, thus, it opens the possibility of a new direction of adjuvant interventional approach in cancer. Keywords: breast cancer, metastasis, extravasation, hemodynamics, drag-reducing polymer, blood cell traffic, microvesselsDing ZJoy MKameneva MVRoy PDove Medical PressarticleBreast cancermetastasisextravasationhemodynamicsdrag reducing polymerblood cell trafficNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 9, Pp 61-65 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Breast cancer metastasis extravasation hemodynamics drag reducing polymer blood cell traffic Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Breast cancer metastasis extravasation hemodynamics drag reducing polymer blood cell traffic Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ding Z Joy M Kameneva MV Roy P Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells
description	Zhijie Ding,1,* Marion Joy,1,* Marina V Kameneva,1-3 Partha Roy1,3-6 1Department of Bioengineering, 2Department of Surgery, 3McGowan Institute of Regenerative Medicine, 4Department of Pathology, 5Department of Cell Biology, 6Magee Women’s Research Institute, University of Pittsburgh, Pittsburgh, PA, USA *These authors contributed equally to this work Abstract: Metastasis is the leading cause of cancer mortality. Extravasation of cancer cells is a critical step of metastasis. We report a novel proof-of-concept study that investigated whether non-toxic blood-soluble chemical agents capable of rheological modification of the near-vessel-wall blood flow can reduce extravasation of tumor cells and subsequent development of metastasis. Using an experimental metastasis model, we demonstrated that systemic administration of nanomolar concentrations of so-called drag-reducing polymer dramatically impeded extravasation and development of pulmonary metastasis of breast cancer cells in mice. This is the first proof-of-principle study to directly demonstrate physical/rheological, as opposed to chemical, way to prevent cancer cells from extravasation and developing metastasis and, thus, it opens the possibility of a new direction of adjuvant interventional approach in cancer. Keywords: breast cancer, metastasis, extravasation, hemodynamics, drag-reducing polymer, blood cell traffic, microvessels
format	article
author	Ding Z Joy M Kameneva MV Roy P
author_facet	Ding Z Joy M Kameneva MV Roy P
author_sort	Ding Z
title	Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells
title_short	Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells
title_full	Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells
title_fullStr	Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells
title_full_unstemmed	Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells
title_sort	nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/094edc5f4c6146c1811dd2cee137131a
work_keys_str_mv	AT dingz nanomolarconcentrationofbloodsolubledragreducingpolymerinhibitsexperimentalmetastasisofhumanbreastcancercells AT joym nanomolarconcentrationofbloodsolubledragreducingpolymerinhibitsexperimentalmetastasisofhumanbreastcancercells AT kamenevamv nanomolarconcentrationofbloodsolubledragreducingpolymerinhibitsexperimentalmetastasisofhumanbreastcancercells AT royp nanomolarconcentrationofbloodsolubledragreducingpolymerinhibitsexperimentalmetastasisofhumanbreastcancercells
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Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells

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