Identification and molecular characterization of non-polio enteroviruses from children with acute flaccid paralysis in West Africa, 2013–2014

Besides polioviruses, non-polio enteroviruses (NPEVs) may also be associated with acute flaccid paralysis (AFP). Because poliomyelitis is on the verge of eradication, more attention should be paid to study NPEVs from non-polio AFP cases and their epidemic patterns. In West African countries the epid...

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Autores principales:	Maria D. Fernandez-Garcia, Ousmane Kebe, Aichatou D. Fall, Kader Ndiaye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/094f514cda4c4a3f9777b6cbffc5283a
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spelling	oai:doaj.org-article:094f514cda4c4a3f9777b6cbffc5283a2021-12-02T15:06:14ZIdentification and molecular characterization of non-polio enteroviruses from children with acute flaccid paralysis in West Africa, 2013–201410.1038/s41598-017-03835-12045-2322https://doaj.org/article/094f514cda4c4a3f9777b6cbffc5283a2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03835-1https://doaj.org/toc/2045-2322Besides polioviruses, non-polio enteroviruses (NPEVs) may also be associated with acute flaccid paralysis (AFP). Because poliomyelitis is on the verge of eradication, more attention should be paid to study NPEVs from non-polio AFP cases and their epidemic patterns. In West African countries the epidemiology of NPEVs remains largely unexplored. We investigated the genetic diversity, frequency, circulation patterns, and molecular epidemiology of NPEVs in seven West African countries by analyzing retrospectively a panel of 3195 stool samples from children with AFP collected through routine poliomyelitis surveillance activities between 2013 and 2014. VP1 sequencing and typing on 201 isolates revealed 39 NPEV types corresponding to EV-A (6.9%), EV-B (90.5%), EV-C (2%) and EV-D (0.5%) species. Echoviruses were isolated most frequently with 138 cases (68.6%), followed by coxsackievirus group B with 35 cases (17.4%). No single NPEV type was remarkably dominant. Interestingly, several rarely described types with limited detection worldwide were identified (EVA76, EVA119, EVB75, EVB77, EVB97, EVC99, CVA20, CVA21 and EVD94). This study demonstrates the extensive diversity and diverse circulation patterns of NPEVs from AFP surveillance and highlights the need to formulate effective long-term strategies to monitor NPEV circulations in West Africa.Maria D. Fernandez-GarciaOusmane KebeAichatou D. FallKader NdiayeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria D. Fernandez-Garcia Ousmane Kebe Aichatou D. Fall Kader Ndiaye Identification and molecular characterization of non-polio enteroviruses from children with acute flaccid paralysis in West Africa, 2013–2014
description	Besides polioviruses, non-polio enteroviruses (NPEVs) may also be associated with acute flaccid paralysis (AFP). Because poliomyelitis is on the verge of eradication, more attention should be paid to study NPEVs from non-polio AFP cases and their epidemic patterns. In West African countries the epidemiology of NPEVs remains largely unexplored. We investigated the genetic diversity, frequency, circulation patterns, and molecular epidemiology of NPEVs in seven West African countries by analyzing retrospectively a panel of 3195 stool samples from children with AFP collected through routine poliomyelitis surveillance activities between 2013 and 2014. VP1 sequencing and typing on 201 isolates revealed 39 NPEV types corresponding to EV-A (6.9%), EV-B (90.5%), EV-C (2%) and EV-D (0.5%) species. Echoviruses were isolated most frequently with 138 cases (68.6%), followed by coxsackievirus group B with 35 cases (17.4%). No single NPEV type was remarkably dominant. Interestingly, several rarely described types with limited detection worldwide were identified (EVA76, EVA119, EVB75, EVB77, EVB97, EVC99, CVA20, CVA21 and EVD94). This study demonstrates the extensive diversity and diverse circulation patterns of NPEVs from AFP surveillance and highlights the need to formulate effective long-term strategies to monitor NPEV circulations in West Africa.
format	article
author	Maria D. Fernandez-Garcia Ousmane Kebe Aichatou D. Fall Kader Ndiaye
author_facet	Maria D. Fernandez-Garcia Ousmane Kebe Aichatou D. Fall Kader Ndiaye
author_sort	Maria D. Fernandez-Garcia
title	Identification and molecular characterization of non-polio enteroviruses from children with acute flaccid paralysis in West Africa, 2013–2014
title_short	Identification and molecular characterization of non-polio enteroviruses from children with acute flaccid paralysis in West Africa, 2013–2014
title_full	Identification and molecular characterization of non-polio enteroviruses from children with acute flaccid paralysis in West Africa, 2013–2014
title_fullStr	Identification and molecular characterization of non-polio enteroviruses from children with acute flaccid paralysis in West Africa, 2013–2014
title_full_unstemmed	Identification and molecular characterization of non-polio enteroviruses from children with acute flaccid paralysis in West Africa, 2013–2014
title_sort	identification and molecular characterization of non-polio enteroviruses from children with acute flaccid paralysis in west africa, 2013–2014
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/094f514cda4c4a3f9777b6cbffc5283a
work_keys_str_mv	AT mariadfernandezgarcia identificationandmolecularcharacterizationofnonpolioenterovirusesfromchildrenwithacuteflaccidparalysisinwestafrica20132014 AT ousmanekebe identificationandmolecularcharacterizationofnonpolioenterovirusesfromchildrenwithacuteflaccidparalysisinwestafrica20132014 AT aichatoudfall identificationandmolecularcharacterizationofnonpolioenterovirusesfromchildrenwithacuteflaccidparalysisinwestafrica20132014 AT kaderndiaye identificationandmolecularcharacterizationofnonpolioenterovirusesfromchildrenwithacuteflaccidparalysisinwestafrica20132014
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Identification and molecular characterization of non-polio enteroviruses from children with acute flaccid paralysis in West Africa, 2013–2014

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