Spindle tubulin and MTOC asymmetries may explain meiotic drive in oocytes

During ‘meiotic drive’, some chromosomes can bias their spindle orientation and thus be retained in the egg. Here, the authors find that this phenomenon can be driven by microtubule force asymmetry on chromosomes with differently sized centromeres and kinetochores.

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Autores principales:	Tianyu Wu, Simon I. R. Lane, Stephanie L. Morgan, Keith T. Jones
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0953c7263e2847f793b9899690e89c1c
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spelling	oai:doaj.org-article:0953c7263e2847f793b9899690e89c1c2021-12-02T15:34:39ZSpindle tubulin and MTOC asymmetries may explain meiotic drive in oocytes10.1038/s41467-018-05338-72041-1723https://doaj.org/article/0953c7263e2847f793b9899690e89c1c2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05338-7https://doaj.org/toc/2041-1723During ‘meiotic drive’, some chromosomes can bias their spindle orientation and thus be retained in the egg. Here, the authors find that this phenomenon can be driven by microtubule force asymmetry on chromosomes with differently sized centromeres and kinetochores.Tianyu WuSimon I. R. LaneStephanie L. MorganKeith T. JonesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tianyu Wu Simon I. R. Lane Stephanie L. Morgan Keith T. Jones Spindle tubulin and MTOC asymmetries may explain meiotic drive in oocytes
description	During ‘meiotic drive’, some chromosomes can bias their spindle orientation and thus be retained in the egg. Here, the authors find that this phenomenon can be driven by microtubule force asymmetry on chromosomes with differently sized centromeres and kinetochores.
format	article
author	Tianyu Wu Simon I. R. Lane Stephanie L. Morgan Keith T. Jones
author_facet	Tianyu Wu Simon I. R. Lane Stephanie L. Morgan Keith T. Jones
author_sort	Tianyu Wu
title	Spindle tubulin and MTOC asymmetries may explain meiotic drive in oocytes
title_short	Spindle tubulin and MTOC asymmetries may explain meiotic drive in oocytes
title_full	Spindle tubulin and MTOC asymmetries may explain meiotic drive in oocytes
title_fullStr	Spindle tubulin and MTOC asymmetries may explain meiotic drive in oocytes
title_full_unstemmed	Spindle tubulin and MTOC asymmetries may explain meiotic drive in oocytes
title_sort	spindle tubulin and mtoc asymmetries may explain meiotic drive in oocytes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0953c7263e2847f793b9899690e89c1c
work_keys_str_mv	AT tianyuwu spindletubulinandmtocasymmetriesmayexplainmeioticdriveinoocytes AT simonirlane spindletubulinandmtocasymmetriesmayexplainmeioticdriveinoocytes AT stephanielmorgan spindletubulinandmtocasymmetriesmayexplainmeioticdriveinoocytes AT keithtjones spindletubulinandmtocasymmetriesmayexplainmeioticdriveinoocytes
_version_	1718386762124886016

Spindle tubulin and MTOC asymmetries may explain meiotic drive in oocytes

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