Association of serum 25-Hydroxy Vitamin D level with lipid, lipoprotein, and apolipoprotein level

Introduction 25-Hydroxy vitamin D (Vit D3) deficiency was found to be associated with vascular dysfunction, arterial stiffening, extent of coronary artery disease and cardiovascular mortality. Previous studies showed positive correlation between serum Vit D3 and HDL-C and negative correlation betwee...

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Autores principales:	Cyrus Elmi, Melton Mingtian Fan, Marjolein Le, Gang Cheng, Koroush Khalighi
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	vitamin d3 dyslipidemia coronary artery disease apolipoprotein lipoprotein Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/0953f8df77c649c7b776298d2676a778
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spelling	oai:doaj.org-article:0953f8df77c649c7b776298d2676a7782021-11-17T14:21:57ZAssociation of serum 25-Hydroxy Vitamin D level with lipid, lipoprotein, and apolipoprotein level2000-966610.1080/20009666.2021.1968571https://doaj.org/article/0953f8df77c649c7b776298d2676a7782021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/20009666.2021.1968571https://doaj.org/toc/2000-9666Introduction 25-Hydroxy vitamin D (Vit D3) deficiency was found to be associated with vascular dysfunction, arterial stiffening, extent of coronary artery disease and cardiovascular mortality. Previous studies showed positive correlation between serum Vit D3 and HDL-C and negative correlation between Vit D3 and LDL-C. The aim of this study is to investigate more details about the possible association of serum Vit D3 level with lipid, lipoprotein and apolipoprotein level. Methods Totally 101 patients were included in this study and Vit D3, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), High-density lipoprotein cholesterol (HDL-C), total triglyceride (TG), non-high-density lipoprotein cholesterol (Non-HDL-C), low-density lipoprotein particle (LDL-P), small dense low-density lipoprotein particle (sLDL-P), small dense low-density lipoprotein cholesterol (sdLDL-C), High-density lipoprotein cholesterol particles (HDL-P), High-density lipoprotein 2-cholesterol (HDL2-C), Apolipoprotein B(ApoB), Apolipoprotein A1 (Apo A1) and Apolipoprotein B/Apolipoprotein A1 ratio (ApoB/A ratio) were tested. Results Our results show that patients with Vit D3 deficiency (Vit D3 < 30 ng/ml) have significantly higher level of LDL-C, TG, Non-HDL-C, LDL-P, sLDL-P, sdLDL-C, ApoB and ApoB/A ratio compare with patients have normal Vit D3 level (Vit D3 > 30 ng/ml). Patients with normal Vit D3 level have significantly higher level of HDL-C and HDL2-C. Correlation study shows that Vit D3 level is negative correlated with TC, LDL-C, TG, Non-HDL-C, LDL-P, sLDL-P, sdLDL-C, ApoB and ApoB/A ratio and positive correlated with HDL2-C level. Conclusion Our results show that Vit D3 deficiency links to an increased risk for dyslipidemia and that may be the reason that patients with vitamin D deficiency tend to have higher risk of coronary artery disease.Cyrus ElmiMelton Mingtian FanMarjolein LeGang ChengKoroush KhalighiTaylor & Francis Grouparticlevitamin d3dyslipidemiacoronary artery diseaseapolipoproteinlipoproteinInternal medicineRC31-1245ENJournal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 6, Pp 812-816 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin d3 dyslipidemia coronary artery disease apolipoprotein lipoprotein Internal medicine RC31-1245
spellingShingle	vitamin d3 dyslipidemia coronary artery disease apolipoprotein lipoprotein Internal medicine RC31-1245 Cyrus Elmi Melton Mingtian Fan Marjolein Le Gang Cheng Koroush Khalighi Association of serum 25-Hydroxy Vitamin D level with lipid, lipoprotein, and apolipoprotein level
description	Introduction 25-Hydroxy vitamin D (Vit D3) deficiency was found to be associated with vascular dysfunction, arterial stiffening, extent of coronary artery disease and cardiovascular mortality. Previous studies showed positive correlation between serum Vit D3 and HDL-C and negative correlation between Vit D3 and LDL-C. The aim of this study is to investigate more details about the possible association of serum Vit D3 level with lipid, lipoprotein and apolipoprotein level. Methods Totally 101 patients were included in this study and Vit D3, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), High-density lipoprotein cholesterol (HDL-C), total triglyceride (TG), non-high-density lipoprotein cholesterol (Non-HDL-C), low-density lipoprotein particle (LDL-P), small dense low-density lipoprotein particle (sLDL-P), small dense low-density lipoprotein cholesterol (sdLDL-C), High-density lipoprotein cholesterol particles (HDL-P), High-density lipoprotein 2-cholesterol (HDL2-C), Apolipoprotein B(ApoB), Apolipoprotein A1 (Apo A1) and Apolipoprotein B/Apolipoprotein A1 ratio (ApoB/A ratio) were tested. Results Our results show that patients with Vit D3 deficiency (Vit D3 < 30 ng/ml) have significantly higher level of LDL-C, TG, Non-HDL-C, LDL-P, sLDL-P, sdLDL-C, ApoB and ApoB/A ratio compare with patients have normal Vit D3 level (Vit D3 > 30 ng/ml). Patients with normal Vit D3 level have significantly higher level of HDL-C and HDL2-C. Correlation study shows that Vit D3 level is negative correlated with TC, LDL-C, TG, Non-HDL-C, LDL-P, sLDL-P, sdLDL-C, ApoB and ApoB/A ratio and positive correlated with HDL2-C level. Conclusion Our results show that Vit D3 deficiency links to an increased risk for dyslipidemia and that may be the reason that patients with vitamin D deficiency tend to have higher risk of coronary artery disease.
format	article
author	Cyrus Elmi Melton Mingtian Fan Marjolein Le Gang Cheng Koroush Khalighi
author_facet	Cyrus Elmi Melton Mingtian Fan Marjolein Le Gang Cheng Koroush Khalighi
author_sort	Cyrus Elmi
title	Association of serum 25-Hydroxy Vitamin D level with lipid, lipoprotein, and apolipoprotein level
title_short	Association of serum 25-Hydroxy Vitamin D level with lipid, lipoprotein, and apolipoprotein level
title_full	Association of serum 25-Hydroxy Vitamin D level with lipid, lipoprotein, and apolipoprotein level
title_fullStr	Association of serum 25-Hydroxy Vitamin D level with lipid, lipoprotein, and apolipoprotein level
title_full_unstemmed	Association of serum 25-Hydroxy Vitamin D level with lipid, lipoprotein, and apolipoprotein level
title_sort	association of serum 25-hydroxy vitamin d level with lipid, lipoprotein, and apolipoprotein level
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/0953f8df77c649c7b776298d2676a778
work_keys_str_mv	AT cyruselmi associationofserum25hydroxyvitamindlevelwithlipidlipoproteinandapolipoproteinlevel AT meltonmingtianfan associationofserum25hydroxyvitamindlevelwithlipidlipoproteinandapolipoproteinlevel AT marjoleinle associationofserum25hydroxyvitamindlevelwithlipidlipoproteinandapolipoproteinlevel AT gangcheng associationofserum25hydroxyvitamindlevelwithlipidlipoproteinandapolipoproteinlevel AT koroushkhalighi associationofserum25hydroxyvitamindlevelwithlipidlipoproteinandapolipoproteinlevel
_version_	1718425461687582720

Association of serum 25-Hydroxy Vitamin D level with lipid, lipoprotein, and apolipoprotein level

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