Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids

Laetitia Keller,1,2,* Ysia Idoux-Gillet,1,2,* Quentin Wagner,1,2,* Sandy Eap,1,2,* David Brasse,3 Pascale Schwinté,1,2 Manuel Arruebo,4 Nadia Benkirane-Jessel1,2 1INSERM (French National Institute of Health and Medical Research), “Osteoarticular and Dental Regenerative Nanomedi...

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Autores principales:	Keller L, Idoux-Gillet Y, Wagner Q, Eap S, Brasse D, Schwinté P, Arruebo M, Benkirane-Jessel N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Bioengineering Implants Osteoblasts Matrix Mineralization Microtissues Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/095540cbec17445ab80bfd3cff7b811a
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spelling	oai:doaj.org-article:095540cbec17445ab80bfd3cff7b811a2021-12-02T00:46:39ZNanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids1178-2013https://doaj.org/article/095540cbec17445ab80bfd3cff7b811a2017-01-01T00:00:00Zhttps://www.dovepress.com/nanoengineered-implant-as-a-new-platform-for-regenerative-nanomedicine-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Laetitia Keller,1,2,* Ysia Idoux-Gillet,1,2,* Quentin Wagner,1,2,* Sandy Eap,1,2,* David Brasse,3 Pascale Schwinté,1,2 Manuel Arruebo,4 Nadia Benkirane-Jessel1,2 1INSERM (French National Institute of Health and Medical Research), “Osteoarticular and Dental Regenerative Nanomedicine” Laboratory, UMR 1109, Faculté de Médecine, FMTS, 2University of Strasbourg, Faculté de Chirurgie Dentaire, 3CNRS (Centre National de la Recherche Scientifique), UMR 7178, IPHC (Hubert Curien Multidisciplinary Institute), Strasbourg, France; 4Department of Chemical Engineering, INA (Aragon Nanoscience Institute), University of Zaragoza, Zaragoza, Spain *These authors contributed equally to this work Abstract: In tissue engineering, it is still rare today to see clinically transferable strategies for tissue-engineered graft production that conclusively offer better tissue regeneration than the already existing technologies, decreased recovery times, and less risk of complications. Here a novel tissue-engineering concept is presented for the production of living bone implants combining 1) a nanofibrous and microporous implant as cell colonization matrix and 2) 3D bone cell spheroids. This combination, double 3D implants, shows clinical relevant thicknesses for the treatment of an early stage of bone lesions before the need of bone substitutes. The strategy presented here shows a complete closure of a defect in nude mice calvaria after only 31 days. As a novel strategy for bone regenerative nanomedicine, it holds great promises to enhance the therapeutic efficacy of living bone implants. Keywords: bioengineering, implants, osteoblasts, matrix mineralization, microtissuesKeller LIdoux-Gillet YWagner QEap SBrasse DSchwinté PArruebo MBenkirane-Jessel NDove Medical PressarticleBioengineeringImplantsOsteoblastsMatrix MineralizationMicrotissuesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 447-457 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bioengineering Implants Osteoblasts Matrix Mineralization Microtissues Medicine (General) R5-920
spellingShingle	Bioengineering Implants Osteoblasts Matrix Mineralization Microtissues Medicine (General) R5-920 Keller L Idoux-Gillet Y Wagner Q Eap S Brasse D Schwinté P Arruebo M Benkirane-Jessel N Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids
description	Laetitia Keller,1,2,* Ysia Idoux-Gillet,1,2,* Quentin Wagner,1,2,* Sandy Eap,1,2,* David Brasse,3 Pascale Schwinté,1,2 Manuel Arruebo,4 Nadia Benkirane-Jessel1,2 1INSERM (French National Institute of Health and Medical Research), “Osteoarticular and Dental Regenerative Nanomedicine” Laboratory, UMR 1109, Faculté de Médecine, FMTS, 2University of Strasbourg, Faculté de Chirurgie Dentaire, 3CNRS (Centre National de la Recherche Scientifique), UMR 7178, IPHC (Hubert Curien Multidisciplinary Institute), Strasbourg, France; 4Department of Chemical Engineering, INA (Aragon Nanoscience Institute), University of Zaragoza, Zaragoza, Spain *These authors contributed equally to this work Abstract: In tissue engineering, it is still rare today to see clinically transferable strategies for tissue-engineered graft production that conclusively offer better tissue regeneration than the already existing technologies, decreased recovery times, and less risk of complications. Here a novel tissue-engineering concept is presented for the production of living bone implants combining 1) a nanofibrous and microporous implant as cell colonization matrix and 2) 3D bone cell spheroids. This combination, double 3D implants, shows clinical relevant thicknesses for the treatment of an early stage of bone lesions before the need of bone substitutes. The strategy presented here shows a complete closure of a defect in nude mice calvaria after only 31 days. As a novel strategy for bone regenerative nanomedicine, it holds great promises to enhance the therapeutic efficacy of living bone implants. Keywords: bioengineering, implants, osteoblasts, matrix mineralization, microtissues
format	article
author	Keller L Idoux-Gillet Y Wagner Q Eap S Brasse D Schwinté P Arruebo M Benkirane-Jessel N
author_facet	Keller L Idoux-Gillet Y Wagner Q Eap S Brasse D Schwinté P Arruebo M Benkirane-Jessel N
author_sort	Keller L
title	Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids
title_short	Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids
title_full	Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids
title_fullStr	Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids
title_full_unstemmed	Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids
title_sort	nanoengineered implant as a new platform for regenerative nanomedicine using 3d well-organized human cell spheroids
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/095540cbec17445ab80bfd3cff7b811a
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_version_	1718403476328808448

Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids

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