Adverse drug events in Chinese pediatric inpatients and associated risk factors: a retrospective review using the Global Trigger Tool

Abstract Understanding the epidemiology and risk factors of adverse drug events (ADEs) in pediatric inpatient is essential if we are to prevent, reduce or ameliorate the harm experienced. The Global Trigger Tool (GTT) is a method of retrospective medical record review that measures harm in hospitali...

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Autores principales:	Huan-huan Ji, Lin Song, Jian-wen Xiao, Yu-xia Guo, Ping Wei, Ting-ting Tang, Xiao-jiang Tian, Xue-wen Tang, Yun-tao Jia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0958d49fa6974051a2a5686bfd84a3f6
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spelling	oai:doaj.org-article:0958d49fa6974051a2a5686bfd84a3f62021-12-02T15:08:11ZAdverse drug events in Chinese pediatric inpatients and associated risk factors: a retrospective review using the Global Trigger Tool10.1038/s41598-018-20868-22045-2322https://doaj.org/article/0958d49fa6974051a2a5686bfd84a3f62018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20868-2https://doaj.org/toc/2045-2322Abstract Understanding the epidemiology and risk factors of adverse drug events (ADEs) in pediatric inpatient is essential if we are to prevent, reduce or ameliorate the harm experienced. The Global Trigger Tool (GTT) is a method of retrospective medical record review that measures harm in hospitalized children. We employed a three-stage retrospective chart review of random samples of 1800 pediatric inpatients discharged from January 2013 to December 2015. 31 kinds of pediatric-specific triggers were made based on the previous trigger tool studies developed for use in adult or pediatric. Positive predictive value (PPV) of individual triggers, as well as ADEs detection rates were calculated. Stepwise logistic regression was performed to investigate risk factors associated with ADEs. Of 1746 patients, detected in 221 patients (12.7%) with 247 ADEs. The PPV of the trigger tool was 13.3%. Of the 247 ADEs, 82.6% were identified as category E, 11.7% category F and 5.7% category H. The pediatric-focused trigger tool is a feasible and useful tool for detecting pediatric ADEs. Especially for patients who have had more drugs, more doses or more admissions which needs to be closely monitored as triggers to improve the safety.Huan-huan JiLin SongJian-wen XiaoYu-xia GuoPing WeiTing-ting TangXiao-jiang TianXue-wen TangYun-tao JiaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huan-huan Ji Lin Song Jian-wen Xiao Yu-xia Guo Ping Wei Ting-ting Tang Xiao-jiang Tian Xue-wen Tang Yun-tao Jia Adverse drug events in Chinese pediatric inpatients and associated risk factors: a retrospective review using the Global Trigger Tool
description	Abstract Understanding the epidemiology and risk factors of adverse drug events (ADEs) in pediatric inpatient is essential if we are to prevent, reduce or ameliorate the harm experienced. The Global Trigger Tool (GTT) is a method of retrospective medical record review that measures harm in hospitalized children. We employed a three-stage retrospective chart review of random samples of 1800 pediatric inpatients discharged from January 2013 to December 2015. 31 kinds of pediatric-specific triggers were made based on the previous trigger tool studies developed for use in adult or pediatric. Positive predictive value (PPV) of individual triggers, as well as ADEs detection rates were calculated. Stepwise logistic regression was performed to investigate risk factors associated with ADEs. Of 1746 patients, detected in 221 patients (12.7%) with 247 ADEs. The PPV of the trigger tool was 13.3%. Of the 247 ADEs, 82.6% were identified as category E, 11.7% category F and 5.7% category H. The pediatric-focused trigger tool is a feasible and useful tool for detecting pediatric ADEs. Especially for patients who have had more drugs, more doses or more admissions which needs to be closely monitored as triggers to improve the safety.
format	article
author	Huan-huan Ji Lin Song Jian-wen Xiao Yu-xia Guo Ping Wei Ting-ting Tang Xiao-jiang Tian Xue-wen Tang Yun-tao Jia
author_facet	Huan-huan Ji Lin Song Jian-wen Xiao Yu-xia Guo Ping Wei Ting-ting Tang Xiao-jiang Tian Xue-wen Tang Yun-tao Jia
author_sort	Huan-huan Ji
title	Adverse drug events in Chinese pediatric inpatients and associated risk factors: a retrospective review using the Global Trigger Tool
title_short	Adverse drug events in Chinese pediatric inpatients and associated risk factors: a retrospective review using the Global Trigger Tool
title_full	Adverse drug events in Chinese pediatric inpatients and associated risk factors: a retrospective review using the Global Trigger Tool
title_fullStr	Adverse drug events in Chinese pediatric inpatients and associated risk factors: a retrospective review using the Global Trigger Tool
title_full_unstemmed	Adverse drug events in Chinese pediatric inpatients and associated risk factors: a retrospective review using the Global Trigger Tool
title_sort	adverse drug events in chinese pediatric inpatients and associated risk factors: a retrospective review using the global trigger tool
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0958d49fa6974051a2a5686bfd84a3f6
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Adverse drug events in Chinese pediatric inpatients and associated risk factors: a retrospective review using the Global Trigger Tool

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