The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma

Tissue-resident F4/80hi macrophages can be found both in normal gut as well as in intestinal tumours. Here the authors show that in the colon these macrophages are CCR2-dependent, while in tumours they gain the ability to self-renew, relying on CSF1 and promoting cancer progression.

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Autores principales:	Irene Soncin, Jianpeng Sheng, Qi Chen, Shihui Foo, Kaibo Duan, Josephine Lum, Michael Poidinger, Francesca Zolezzi, Klaus Karjalainen, Christiane Ruedl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/095c4870307447429bbbc8eaff0cf1e6
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spelling	oai:doaj.org-article:095c4870307447429bbbc8eaff0cf1e62021-12-02T15:33:44ZThe tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma10.1038/s41467-018-02834-82041-1723https://doaj.org/article/095c4870307447429bbbc8eaff0cf1e62018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02834-8https://doaj.org/toc/2041-1723Tissue-resident F4/80hi macrophages can be found both in normal gut as well as in intestinal tumours. Here the authors show that in the colon these macrophages are CCR2-dependent, while in tumours they gain the ability to self-renew, relying on CSF1 and promoting cancer progression.Irene SoncinJianpeng ShengQi ChenShihui FooKaibo DuanJosephine LumMichael PoidingerFrancesca ZolezziKlaus KarjalainenChristiane RuedlNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Irene Soncin Jianpeng Sheng Qi Chen Shihui Foo Kaibo Duan Josephine Lum Michael Poidinger Francesca Zolezzi Klaus Karjalainen Christiane Ruedl The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma
description	Tissue-resident F4/80hi macrophages can be found both in normal gut as well as in intestinal tumours. Here the authors show that in the colon these macrophages are CCR2-dependent, while in tumours they gain the ability to self-renew, relying on CSF1 and promoting cancer progression.
format	article
author	Irene Soncin Jianpeng Sheng Qi Chen Shihui Foo Kaibo Duan Josephine Lum Michael Poidinger Francesca Zolezzi Klaus Karjalainen Christiane Ruedl
author_facet	Irene Soncin Jianpeng Sheng Qi Chen Shihui Foo Kaibo Duan Josephine Lum Michael Poidinger Francesca Zolezzi Klaus Karjalainen Christiane Ruedl
author_sort	Irene Soncin
title	The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma
title_short	The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma
title_full	The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma
title_fullStr	The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma
title_full_unstemmed	The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma
title_sort	tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/095c4870307447429bbbc8eaff0cf1e6
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The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma

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