ENU mutagenesis reveals a novel phenotype of reduced limb strength in mice lacking fibrillin 2.

ENU mutagenesis reveals a novel phenotype of reduced limb strength in mice lacking fibrillin 2.

<h4>Background</h4>Fibrillins 1 (FBN1) and 2 (FBN2) are components of microfibrils, microfilaments that are present in many connective tissues, either alone or in association with elastin. Marfan's syndrome and congenital contractural arachnodactyly (CCA) result from dominant mutati...

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Main Authors: Gaynor Miller, Monica Neilan, Ruth Chia, Nabeia Gheryani, Natalie Holt, Annabelle Charbit, Sara Wells, Valter Tucci, Zuzanne Lalanne, Paul Denny, Elizabeth M C Fisher, Michael Cheeseman, Graham N Askew, T Neil Dear
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2010
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/095c5bd1ac0c4528b8de42f504717eeb
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https://doaj.org/article/095c5bd1ac0c4528b8de42f504717eeb

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