RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family

Osteoarthritis is characterised by degeneration of joint cartilage. Here the authors show that the RNA-binding protein ZFP36L1 is upregulated in chondrocytes of humans and mice with osteoarthritis, and that its knockdown in mouse joints protects chondrocytes against apoptosis by modulating the funct...

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Autores principales:	Young-Ok Son, Hyo-Eun Kim, Wan-Su Choi, Churl-Hong Chun, Jang-Soo Chun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/095fcf13e8894eaf918d58885ed8bdac
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spelling	oai:doaj.org-article:095fcf13e8894eaf918d58885ed8bdac2021-12-02T15:36:20ZRNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family10.1038/s41467-018-08035-72041-1723https://doaj.org/article/095fcf13e8894eaf918d58885ed8bdac2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08035-7https://doaj.org/toc/2041-1723Osteoarthritis is characterised by degeneration of joint cartilage. Here the authors show that the RNA-binding protein ZFP36L1 is upregulated in chondrocytes of humans and mice with osteoarthritis, and that its knockdown in mouse joints protects chondrocytes against apoptosis by modulating the function of heat shock proteins.Young-Ok SonHyo-Eun KimWan-Su ChoiChurl-Hong ChunJang-Soo ChunNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Young-Ok Son Hyo-Eun Kim Wan-Su Choi Churl-Hong Chun Jang-Soo Chun RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family
description	Osteoarthritis is characterised by degeneration of joint cartilage. Here the authors show that the RNA-binding protein ZFP36L1 is upregulated in chondrocytes of humans and mice with osteoarthritis, and that its knockdown in mouse joints protects chondrocytes against apoptosis by modulating the function of heat shock proteins.
format	article
author	Young-Ok Son Hyo-Eun Kim Wan-Su Choi Churl-Hong Chun Jang-Soo Chun
author_facet	Young-Ok Son Hyo-Eun Kim Wan-Su Choi Churl-Hong Chun Jang-Soo Chun
author_sort	Young-Ok Son
title	RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family
title_short	RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family
title_full	RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family
title_fullStr	RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family
title_full_unstemmed	RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family
title_sort	rna-binding protein zfp36l1 regulates osteoarthritis by modulating members of the heat shock protein 70 family
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/095fcf13e8894eaf918d58885ed8bdac
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RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family

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