Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and 18F-FDG PET/CT
Abstract In multiple myeloma (MM), a high number of focal lesions (FL) detected using positron emission tomography/computed tomography (PET/CT) was found to be associated with adverse prognosis. To design a new risk stratification system that combines the Revised International Staging System (R-ISS)...
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Nature Publishing Group
2021
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oai:doaj.org-article:0960ae35758a464c82ae284b692a69882021-12-05T12:25:50ZDevelopment of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and 18F-FDG PET/CT10.1038/s41408-021-00577-22044-5385https://doaj.org/article/0960ae35758a464c82ae284b692a69882021-12-01T00:00:00Zhttps://doi.org/10.1038/s41408-021-00577-2https://doaj.org/toc/2044-5385Abstract In multiple myeloma (MM), a high number of focal lesions (FL) detected using positron emission tomography/computed tomography (PET/CT) was found to be associated with adverse prognosis. To design a new risk stratification system that combines the Revised International Staging System (R-ISS) with FL, we analyzed the data of 380 patients with newly diagnosed MM (NDMM) who underwent 18F-fluorodeoxyglucose (18F-FDG) PET/CT upon diagnosis. The K-adaptive partitioning algorithm was adopted to define subgroups with homogeneous survival. The combined R-ISS with PET/CT classified NDMM patients into four groups: R-ISS/PET stage I (n = 31; R-ISS I with FL ≤ 3), stage II (n = 156; R-ISS I with FL > 3 and R-ISS II with FL ≤ 3), stage III (n = 162; R-ISS II with FL > 3 and R-ISS III with FL ≤ 3), and stage IV (n = 31; R-ISS III with FL > 3). The 2-year overall survival rates for stages I, II, III, and IV were 96.7%, 89.8%, 74.7%, and 50.3%. The 2-year progression-free survival rates were 84.1%, 64.7%, 40.8%, and 17.1%, respectively. The new R-ISS/PET was successfully validated in an external cohort. This new system had a remarkable prognostic power for estimating the survival outcomes of patients with NDMM. This system helps discriminate patients with a good prognosis from those with a poor prognosis more precisely.Hee Jeong ChoSung-Hoon JungJae-Cheol JoYoo Jin LeeSang Eun YoonSung-Soo ParkDo Young KimHo-Jin ShinYeung-Chul MunJun Ho YiHyo Jung KimDa Jung KimHo Sup LeeSung Hwa BaeChae Moon HongShin Young JeongJung-Joon MinSang Kyun SohnChang-Ki MinKihyun KimJe-Jung LeeJoon Ho MoonThe Korean Multiple Myeloma Working PartyNature Publishing GrouparticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBlood Cancer Journal, Vol 11, Iss 12, Pp 1-8 (2021) |
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DOAJ |
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EN |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hee Jeong Cho Sung-Hoon Jung Jae-Cheol Jo Yoo Jin Lee Sang Eun Yoon Sung-Soo Park Do Young Kim Ho-Jin Shin Yeung-Chul Mun Jun Ho Yi Hyo Jung Kim Da Jung Kim Ho Sup Lee Sung Hwa Bae Chae Moon Hong Shin Young Jeong Jung-Joon Min Sang Kyun Sohn Chang-Ki Min Kihyun Kim Je-Jung Lee Joon Ho Moon The Korean Multiple Myeloma Working Party Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and 18F-FDG PET/CT |
| description |
Abstract In multiple myeloma (MM), a high number of focal lesions (FL) detected using positron emission tomography/computed tomography (PET/CT) was found to be associated with adverse prognosis. To design a new risk stratification system that combines the Revised International Staging System (R-ISS) with FL, we analyzed the data of 380 patients with newly diagnosed MM (NDMM) who underwent 18F-fluorodeoxyglucose (18F-FDG) PET/CT upon diagnosis. The K-adaptive partitioning algorithm was adopted to define subgroups with homogeneous survival. The combined R-ISS with PET/CT classified NDMM patients into four groups: R-ISS/PET stage I (n = 31; R-ISS I with FL ≤ 3), stage II (n = 156; R-ISS I with FL > 3 and R-ISS II with FL ≤ 3), stage III (n = 162; R-ISS II with FL > 3 and R-ISS III with FL ≤ 3), and stage IV (n = 31; R-ISS III with FL > 3). The 2-year overall survival rates for stages I, II, III, and IV were 96.7%, 89.8%, 74.7%, and 50.3%. The 2-year progression-free survival rates were 84.1%, 64.7%, 40.8%, and 17.1%, respectively. The new R-ISS/PET was successfully validated in an external cohort. This new system had a remarkable prognostic power for estimating the survival outcomes of patients with NDMM. This system helps discriminate patients with a good prognosis from those with a poor prognosis more precisely. |
| format |
article |
| author |
Hee Jeong Cho Sung-Hoon Jung Jae-Cheol Jo Yoo Jin Lee Sang Eun Yoon Sung-Soo Park Do Young Kim Ho-Jin Shin Yeung-Chul Mun Jun Ho Yi Hyo Jung Kim Da Jung Kim Ho Sup Lee Sung Hwa Bae Chae Moon Hong Shin Young Jeong Jung-Joon Min Sang Kyun Sohn Chang-Ki Min Kihyun Kim Je-Jung Lee Joon Ho Moon The Korean Multiple Myeloma Working Party |
| author_facet |
Hee Jeong Cho Sung-Hoon Jung Jae-Cheol Jo Yoo Jin Lee Sang Eun Yoon Sung-Soo Park Do Young Kim Ho-Jin Shin Yeung-Chul Mun Jun Ho Yi Hyo Jung Kim Da Jung Kim Ho Sup Lee Sung Hwa Bae Chae Moon Hong Shin Young Jeong Jung-Joon Min Sang Kyun Sohn Chang-Ki Min Kihyun Kim Je-Jung Lee Joon Ho Moon The Korean Multiple Myeloma Working Party |
| author_sort |
Hee Jeong Cho |
| title |
Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and 18F-FDG PET/CT |
| title_short |
Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and 18F-FDG PET/CT |
| title_full |
Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and 18F-FDG PET/CT |
| title_fullStr |
Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and 18F-FDG PET/CT |
| title_full_unstemmed |
Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and 18F-FDG PET/CT |
| title_sort |
development of a new risk stratification system for patients with newly diagnosed multiple myeloma using r-iss and 18f-fdg pet/ct |
| publisher |
Nature Publishing Group |
| publishDate |
2021 |
| url |
https://doaj.org/article/0960ae35758a464c82ae284b692a6988 |
| work_keys_str_mv |
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