Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly

Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly

Vesicle associated membrane protein 2 (VAMP2) contains a conserved SNARE motif that interacts with syntaxin-1 and SNAP25 for SNARE complex assembly. Here authors use in-cell NMR spectroscopy to describe the dynamic membrane association of VAMP2 SNARE motif in mammalian cells at the atomic resolution...

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Autores principales: Chuchu Wang, Jia Tu, Shengnan Zhang, Bin Cai, Zhenying Liu, Shouqiao Hou, Qinglu Zhong, Xiao Hu, Wenbin Liu, Guohui Li, Zhijun Liu, Lin He, Jiajie Diao, Zheng-Jiang Zhu, Dan Li, Cong Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/0967f87a5aae4500b37410d2f85f412c
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Sumario:Vesicle associated membrane protein 2 (VAMP2) contains a conserved SNARE motif that interacts with syntaxin-1 and SNAP25 for SNARE complex assembly. Here authors use in-cell NMR spectroscopy to describe the dynamic membrane association of VAMP2 SNARE motif in mammalian cells at the atomic resolution.

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