Mesenchymal stem cell therapy induces FLT3L and CD1c+ dendritic cells in systemic lupus erythematosus patients

Promising pilot clinical trials of mesenchymal stem cells (MSCs) therapy of lupus await validation in larger, controlled trials. Here the authors show that MSCs expand CD1c+ dendritic cells in cell culture by producing FLT3L, and that in lupus patients, circulating CD1c+ dendritic cells and FLT3L ar...

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Autores principales:	Xinran Yuan, Xiaodong Qin, Dandan Wang, Zhuoya Zhang, Xiaojun Tang, Xiang Gao, Wanjun Chen, Lingyun Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0968493e79944ad1a28dcb184a255e38
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spelling	oai:doaj.org-article:0968493e79944ad1a28dcb184a255e382021-12-02T14:35:43ZMesenchymal stem cell therapy induces FLT3L and CD1c+ dendritic cells in systemic lupus erythematosus patients10.1038/s41467-019-10491-82041-1723https://doaj.org/article/0968493e79944ad1a28dcb184a255e382019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10491-8https://doaj.org/toc/2041-1723Promising pilot clinical trials of mesenchymal stem cells (MSCs) therapy of lupus await validation in larger, controlled trials. Here the authors show that MSCs expand CD1c+ dendritic cells in cell culture by producing FLT3L, and that in lupus patients, circulating CD1c+ dendritic cells and FLT3L are increased following MSCs therapy.Xinran YuanXiaodong QinDandan WangZhuoya ZhangXiaojun TangXiang GaoWanjun ChenLingyun SunNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xinran Yuan Xiaodong Qin Dandan Wang Zhuoya Zhang Xiaojun Tang Xiang Gao Wanjun Chen Lingyun Sun Mesenchymal stem cell therapy induces FLT3L and CD1c+ dendritic cells in systemic lupus erythematosus patients
description	Promising pilot clinical trials of mesenchymal stem cells (MSCs) therapy of lupus await validation in larger, controlled trials. Here the authors show that MSCs expand CD1c+ dendritic cells in cell culture by producing FLT3L, and that in lupus patients, circulating CD1c+ dendritic cells and FLT3L are increased following MSCs therapy.
format	article
author	Xinran Yuan Xiaodong Qin Dandan Wang Zhuoya Zhang Xiaojun Tang Xiang Gao Wanjun Chen Lingyun Sun
author_facet	Xinran Yuan Xiaodong Qin Dandan Wang Zhuoya Zhang Xiaojun Tang Xiang Gao Wanjun Chen Lingyun Sun
author_sort	Xinran Yuan
title	Mesenchymal stem cell therapy induces FLT3L and CD1c+ dendritic cells in systemic lupus erythematosus patients
title_short	Mesenchymal stem cell therapy induces FLT3L and CD1c+ dendritic cells in systemic lupus erythematosus patients
title_full	Mesenchymal stem cell therapy induces FLT3L and CD1c+ dendritic cells in systemic lupus erythematosus patients
title_fullStr	Mesenchymal stem cell therapy induces FLT3L and CD1c+ dendritic cells in systemic lupus erythematosus patients
title_full_unstemmed	Mesenchymal stem cell therapy induces FLT3L and CD1c+ dendritic cells in systemic lupus erythematosus patients
title_sort	mesenchymal stem cell therapy induces flt3l and cd1c+ dendritic cells in systemic lupus erythematosus patients
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0968493e79944ad1a28dcb184a255e38
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Mesenchymal stem cell therapy induces FLT3L and CD1c+ dendritic cells in systemic lupus erythematosus patients

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