Intermittent fasting from dawn to sunset for four consecutive weeks induces anticancer serum proteome response and improves metabolic syndrome

Abstract Metabolic syndrome is characterized by central obesity, insulin resistance, elevated blood pressure, and dyslipidemia. Metabolic syndrome is a significant risk factor for several common cancers (e.g., liver, colorectal, breast, pancreas). Pharmacologic treatments used for the components of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ayse L. Mindikoglu, Mustafa M. Abdulsada, Antrix Jain, Prasun K. Jalal, Sridevi Devaraj, Zoe R. Wilhelm, Antone R. Opekun, Sung Yun Jung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/096ec80f4d2c41b0951e11851e6fe471
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:096ec80f4d2c41b0951e11851e6fe471
record_format	dspace
spelling	oai:doaj.org-article:096ec80f4d2c41b0951e11851e6fe4712021-12-02T15:10:07ZIntermittent fasting from dawn to sunset for four consecutive weeks induces anticancer serum proteome response and improves metabolic syndrome10.1038/s41598-020-73767-w2045-2322https://doaj.org/article/096ec80f4d2c41b0951e11851e6fe4712020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-73767-whttps://doaj.org/toc/2045-2322Abstract Metabolic syndrome is characterized by central obesity, insulin resistance, elevated blood pressure, and dyslipidemia. Metabolic syndrome is a significant risk factor for several common cancers (e.g., liver, colorectal, breast, pancreas). Pharmacologic treatments used for the components of the metabolic syndrome appear to be insufficient to control cancer development in subjects with metabolic syndrome. Murine models showed that cancer has the slowest progression when there is no food consumption during the daily activity phase. Intermittent fasting from dawn to sunset is a form of fasting practiced during human activity hours. To test the anticancer effect of intermittent fasting from dawn to sunset in metabolic syndrome, we conducted a pilot study in 14 subjects with metabolic syndrome who fasted (no eating or drinking) from dawn to sunset for more than 14 h daily for four consecutive weeks. We collected serum samples before 4-week intermittent fasting, at the end of 4th week during 4-week intermittent fasting and 1 week after 4-week intermittent fasting. We performed serum proteomic analysis using nano ultra-high performance liquid chromatography-tandem mass spectrometry. We found a significant fold increase in the levels of several tumor suppressor and DNA repair gene protein products (GP)s at the end of 4th week during 4-week intermittent fasting (CALU, INTS6, KIT, CROCC, PIGR), and 1 week after 4-week intermittent fasting (CALU, CALR, IGFBP4, SEMA4B) compared with the levels before 4-week intermittent fasting. We also found a significant reduction in the levels of tumor promoter GPs at the end of 4th week during 4-week intermittent fasting (POLK, CD109, CAMP, NIFK, SRGN), and 1 week after 4-week intermittent fasting (CAMP, PLAC1) compared with the levels before 4-week intermittent fasting. Fasting from dawn to sunset for four weeks also induced an anti-diabetes proteome response by upregulating the key regulatory proteins of insulin signaling at the end of 4th week during 4-week intermittent fasting (VPS8, POLRMT, IGFBP-5) and 1 week after 4-week intermittent fasting (PRKCSH), and an anti-aging proteome response by upregulating H2B histone proteins 1 week after 4-week intermittent fasting. Subjects had a significant reduction in body mass index, waist circumference, and improvement in blood pressure that co-occurred with the anticancer, anti-diabetes, and anti-aging serum proteome response. These findings suggest that intermittent fasting from dawn to sunset actively modulates the respective genes and can be an adjunct treatment in metabolic syndrome. Further studies are needed to test the intermittent fasting from dawn to sunset in the prevention and treatment of metabolic syndrome-induced cancers.Ayse L. MindikogluMustafa M. AbdulsadaAntrix JainPrasun K. JalalSridevi DevarajZoe R. WilhelmAntone R. OpekunSung Yun JungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ayse L. Mindikoglu Mustafa M. Abdulsada Antrix Jain Prasun K. Jalal Sridevi Devaraj Zoe R. Wilhelm Antone R. Opekun Sung Yun Jung Intermittent fasting from dawn to sunset for four consecutive weeks induces anticancer serum proteome response and improves metabolic syndrome
description	Abstract Metabolic syndrome is characterized by central obesity, insulin resistance, elevated blood pressure, and dyslipidemia. Metabolic syndrome is a significant risk factor for several common cancers (e.g., liver, colorectal, breast, pancreas). Pharmacologic treatments used for the components of the metabolic syndrome appear to be insufficient to control cancer development in subjects with metabolic syndrome. Murine models showed that cancer has the slowest progression when there is no food consumption during the daily activity phase. Intermittent fasting from dawn to sunset is a form of fasting practiced during human activity hours. To test the anticancer effect of intermittent fasting from dawn to sunset in metabolic syndrome, we conducted a pilot study in 14 subjects with metabolic syndrome who fasted (no eating or drinking) from dawn to sunset for more than 14 h daily for four consecutive weeks. We collected serum samples before 4-week intermittent fasting, at the end of 4th week during 4-week intermittent fasting and 1 week after 4-week intermittent fasting. We performed serum proteomic analysis using nano ultra-high performance liquid chromatography-tandem mass spectrometry. We found a significant fold increase in the levels of several tumor suppressor and DNA repair gene protein products (GP)s at the end of 4th week during 4-week intermittent fasting (CALU, INTS6, KIT, CROCC, PIGR), and 1 week after 4-week intermittent fasting (CALU, CALR, IGFBP4, SEMA4B) compared with the levels before 4-week intermittent fasting. We also found a significant reduction in the levels of tumor promoter GPs at the end of 4th week during 4-week intermittent fasting (POLK, CD109, CAMP, NIFK, SRGN), and 1 week after 4-week intermittent fasting (CAMP, PLAC1) compared with the levels before 4-week intermittent fasting. Fasting from dawn to sunset for four weeks also induced an anti-diabetes proteome response by upregulating the key regulatory proteins of insulin signaling at the end of 4th week during 4-week intermittent fasting (VPS8, POLRMT, IGFBP-5) and 1 week after 4-week intermittent fasting (PRKCSH), and an anti-aging proteome response by upregulating H2B histone proteins 1 week after 4-week intermittent fasting. Subjects had a significant reduction in body mass index, waist circumference, and improvement in blood pressure that co-occurred with the anticancer, anti-diabetes, and anti-aging serum proteome response. These findings suggest that intermittent fasting from dawn to sunset actively modulates the respective genes and can be an adjunct treatment in metabolic syndrome. Further studies are needed to test the intermittent fasting from dawn to sunset in the prevention and treatment of metabolic syndrome-induced cancers.
format	article
author	Ayse L. Mindikoglu Mustafa M. Abdulsada Antrix Jain Prasun K. Jalal Sridevi Devaraj Zoe R. Wilhelm Antone R. Opekun Sung Yun Jung
author_facet	Ayse L. Mindikoglu Mustafa M. Abdulsada Antrix Jain Prasun K. Jalal Sridevi Devaraj Zoe R. Wilhelm Antone R. Opekun Sung Yun Jung
author_sort	Ayse L. Mindikoglu
title	Intermittent fasting from dawn to sunset for four consecutive weeks induces anticancer serum proteome response and improves metabolic syndrome
title_short	Intermittent fasting from dawn to sunset for four consecutive weeks induces anticancer serum proteome response and improves metabolic syndrome
title_full	Intermittent fasting from dawn to sunset for four consecutive weeks induces anticancer serum proteome response and improves metabolic syndrome
title_fullStr	Intermittent fasting from dawn to sunset for four consecutive weeks induces anticancer serum proteome response and improves metabolic syndrome
title_full_unstemmed	Intermittent fasting from dawn to sunset for four consecutive weeks induces anticancer serum proteome response and improves metabolic syndrome
title_sort	intermittent fasting from dawn to sunset for four consecutive weeks induces anticancer serum proteome response and improves metabolic syndrome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/096ec80f4d2c41b0951e11851e6fe471
work_keys_str_mv	AT ayselmindikoglu intermittentfastingfromdawntosunsetforfourconsecutiveweeksinducesanticancerserumproteomeresponseandimprovesmetabolicsyndrome AT mustafamabdulsada intermittentfastingfromdawntosunsetforfourconsecutiveweeksinducesanticancerserumproteomeresponseandimprovesmetabolicsyndrome AT antrixjain intermittentfastingfromdawntosunsetforfourconsecutiveweeksinducesanticancerserumproteomeresponseandimprovesmetabolicsyndrome AT prasunkjalal intermittentfastingfromdawntosunsetforfourconsecutiveweeksinducesanticancerserumproteomeresponseandimprovesmetabolicsyndrome AT sridevidevaraj intermittentfastingfromdawntosunsetforfourconsecutiveweeksinducesanticancerserumproteomeresponseandimprovesmetabolicsyndrome AT zoerwilhelm intermittentfastingfromdawntosunsetforfourconsecutiveweeksinducesanticancerserumproteomeresponseandimprovesmetabolicsyndrome AT antoneropekun intermittentfastingfromdawntosunsetforfourconsecutiveweeksinducesanticancerserumproteomeresponseandimprovesmetabolicsyndrome AT sungyunjung intermittentfastingfromdawntosunsetforfourconsecutiveweeksinducesanticancerserumproteomeresponseandimprovesmetabolicsyndrome
_version_	1718387733708144640

Intermittent fasting from dawn to sunset for four consecutive weeks induces anticancer serum proteome response and improves metabolic syndrome

Ejemplares similares