Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas

Abstract In this study, four canine distemper virus (CDV) strains were isolated from captive Siberian tigers (Panthera tigris altaica) and red pandas (Ailurus fulgens) during two separate CDV outbreaks in a zoo in Guangdong province, China. Sequence alignment and phylogenetic analyses based on the f...

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Autores principales:	He Zhang, Fen Shan, Xia Zhou, Bing Li, Jun-Qiong Zhai, Shu-Zhan Zou, Meng-Fan Wu, Wu Chen, Shao-Lun Zhai, Man-Lin Luo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/096f9046234449a7bd8f6054afb1fd79
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spelling	oai:doaj.org-article:096f9046234449a7bd8f6054afb1fd792021-12-02T11:52:22ZOutbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas10.1038/s41598-017-08462-42045-2322https://doaj.org/article/096f9046234449a7bd8f6054afb1fd792017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08462-4https://doaj.org/toc/2045-2322Abstract In this study, four canine distemper virus (CDV) strains were isolated from captive Siberian tigers (Panthera tigris altaica) and red pandas (Ailurus fulgens) during two separate CDV outbreaks in a zoo in Guangdong province, China. Sequence alignment and phylogenetic analyses based on the full-length hemagglutinin (H) and fusion (F) genes showed that they were closely identical to genotype Asia-1. Prior to confirmation of CDV in Siberian tigers, to control spread of the disease, a live attenuated combination CDV vaccine was used among almost all carnivore animals except for red pandas in which another recombinant combination CDV vaccine was used. However, about two months later, CDV re-emerged and caused the death among red pandas. Based on the vaccination records, the live combination vaccine could be considered an ideal weapon against CDV in zoo carnivore animals. Although the recombinant combination CDV vaccine was safe for red pandas, its protection effectiveness remains to be further investigated. Moreover, according to the outbreak interval time and sequence characterization, we suspected that stray cats circulating in the zoo were the intermediate host, which contributed to CDV spread from stray dogs to zoo animals. This study revealed the importance of vaccination and biosecurity for zoo animals.He ZhangFen ShanXia ZhouBing LiJun-Qiong ZhaiShu-Zhan ZouMeng-Fan WuWu ChenShao-Lun ZhaiMan-Lin LuoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q He Zhang Fen Shan Xia Zhou Bing Li Jun-Qiong Zhai Shu-Zhan Zou Meng-Fan Wu Wu Chen Shao-Lun Zhai Man-Lin Luo Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas
description	Abstract In this study, four canine distemper virus (CDV) strains were isolated from captive Siberian tigers (Panthera tigris altaica) and red pandas (Ailurus fulgens) during two separate CDV outbreaks in a zoo in Guangdong province, China. Sequence alignment and phylogenetic analyses based on the full-length hemagglutinin (H) and fusion (F) genes showed that they were closely identical to genotype Asia-1. Prior to confirmation of CDV in Siberian tigers, to control spread of the disease, a live attenuated combination CDV vaccine was used among almost all carnivore animals except for red pandas in which another recombinant combination CDV vaccine was used. However, about two months later, CDV re-emerged and caused the death among red pandas. Based on the vaccination records, the live combination vaccine could be considered an ideal weapon against CDV in zoo carnivore animals. Although the recombinant combination CDV vaccine was safe for red pandas, its protection effectiveness remains to be further investigated. Moreover, according to the outbreak interval time and sequence characterization, we suspected that stray cats circulating in the zoo were the intermediate host, which contributed to CDV spread from stray dogs to zoo animals. This study revealed the importance of vaccination and biosecurity for zoo animals.
format	article
author	He Zhang Fen Shan Xia Zhou Bing Li Jun-Qiong Zhai Shu-Zhan Zou Meng-Fan Wu Wu Chen Shao-Lun Zhai Man-Lin Luo
author_facet	He Zhang Fen Shan Xia Zhou Bing Li Jun-Qiong Zhai Shu-Zhan Zou Meng-Fan Wu Wu Chen Shao-Lun Zhai Man-Lin Luo
author_sort	He Zhang
title	Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas
title_short	Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas
title_full	Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas
title_fullStr	Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas
title_full_unstemmed	Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas
title_sort	outbreak and genotyping of canine distemper virus in captive siberian tigers and red pandas
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/096f9046234449a7bd8f6054afb1fd79
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Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas

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