AAV vector-mediated in vivo reprogramming into pluripotency

In vivo reprogramming of somatic cells is hampered by the need for vectors to express the OKSM factors in selected organs. Here the authors report new AAV-based vectors capable of in vivo reprogramming at low doses.

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Autores principales:	Elena Senís, Lluc Mosteiro, Stefan Wilkening, Ellen Wiedtke, Ali Nowrouzi, Saira Afzal, Raffaele Fronza, Henrik Landerer, Maria Abad, Dominik Niopek, Manfred Schmidt, Manuel Serrano, Dirk Grimm
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/097051282c3e433e8f3bfa8162e92d23
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spelling	oai:doaj.org-article:097051282c3e433e8f3bfa8162e92d232021-12-02T17:31:27ZAAV vector-mediated in vivo reprogramming into pluripotency10.1038/s41467-018-05059-x2041-1723https://doaj.org/article/097051282c3e433e8f3bfa8162e92d232018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05059-xhttps://doaj.org/toc/2041-1723In vivo reprogramming of somatic cells is hampered by the need for vectors to express the OKSM factors in selected organs. Here the authors report new AAV-based vectors capable of in vivo reprogramming at low doses.Elena SenísLluc MosteiroStefan WilkeningEllen WiedtkeAli NowrouziSaira AfzalRaffaele FronzaHenrik LandererMaria AbadDominik NiopekManfred SchmidtManuel SerranoDirk GrimmNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elena Senís Lluc Mosteiro Stefan Wilkening Ellen Wiedtke Ali Nowrouzi Saira Afzal Raffaele Fronza Henrik Landerer Maria Abad Dominik Niopek Manfred Schmidt Manuel Serrano Dirk Grimm AAV vector-mediated in vivo reprogramming into pluripotency
description	In vivo reprogramming of somatic cells is hampered by the need for vectors to express the OKSM factors in selected organs. Here the authors report new AAV-based vectors capable of in vivo reprogramming at low doses.
format	article
author	Elena Senís Lluc Mosteiro Stefan Wilkening Ellen Wiedtke Ali Nowrouzi Saira Afzal Raffaele Fronza Henrik Landerer Maria Abad Dominik Niopek Manfred Schmidt Manuel Serrano Dirk Grimm
author_facet	Elena Senís Lluc Mosteiro Stefan Wilkening Ellen Wiedtke Ali Nowrouzi Saira Afzal Raffaele Fronza Henrik Landerer Maria Abad Dominik Niopek Manfred Schmidt Manuel Serrano Dirk Grimm
author_sort	Elena Senís
title	AAV vector-mediated in vivo reprogramming into pluripotency
title_short	AAV vector-mediated in vivo reprogramming into pluripotency
title_full	AAV vector-mediated in vivo reprogramming into pluripotency
title_fullStr	AAV vector-mediated in vivo reprogramming into pluripotency
title_full_unstemmed	AAV vector-mediated in vivo reprogramming into pluripotency
title_sort	aav vector-mediated in vivo reprogramming into pluripotency
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/097051282c3e433e8f3bfa8162e92d23
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AAV vector-mediated in vivo reprogramming into pluripotency

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