Side effects and Immunogenicity following administration of the Sputnik V COVID-19 vaccine in health care workers in Iran

Abstract The Sputnik V is a COVID- 19 vaccine developed by the Gamalia institute of epidemiology and microbiology and released on August 11, 2020. We provided independent evidence on side effects and immunogenicity following the administration of the Sputnik V COVID-19 in Iran. In this observational...

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Autores principales:	Farhang Babamahmoodi, Majid Saeedi, Reza Alizadeh-Navaei, Akbar Hedayatizadeh-Omran, Seyed Abbas Mousavi, Gasem Ovaise, Shirafkan Kordi, Zahra Akbari, Mazaher Azordeh, Fatemeh Ahangarkani, Ahmad Alikhani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0971570018154763af5766e40f50aa52
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spelling	oai:doaj.org-article:0971570018154763af5766e40f50aa522021-11-08T10:52:09ZSide effects and Immunogenicity following administration of the Sputnik V COVID-19 vaccine in health care workers in Iran10.1038/s41598-021-00963-72045-2322https://doaj.org/article/0971570018154763af5766e40f50aa522021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00963-7https://doaj.org/toc/2045-2322Abstract The Sputnik V is a COVID- 19 vaccine developed by the Gamalia institute of epidemiology and microbiology and released on August 11, 2020. We provided independent evidence on side effects and immunogenicity following the administration of the Sputnik V COVID-19 in Iran. In this observational study, the healthcare workers who were vaccinated with the Sputnik V COVID-19 vaccine within February and April 2021 were evaluated. Among a total of 13,435 vaccinated healthcare workers, we received 3236 self-declaration reports of Sputnik V associated adverse events with the mean age 39.32 ± 10.19 years old which 38.8% were men and 61.2% were women. Totally 68.8% of females versus 66.2% of males reported side effects after receiving the first dose and 31.2% of females versus 33.8% of males reported side effects after the second dose of vaccine. The most common side effect was a pain in the injection site (56.9%), fatigue (50.9%), body pain (43.9%), headache (35.7%), fever (32.9%), joint pain (30.3%), chilling (29.8%) and drowsiness (20.3%). Side effects of the vaccine were significantly more frequent in females and younger individuals. Among a total of 238 participants, more than 90% after the first and second dose of vaccine had a detectable level of SARS-CoV-2 RBD antibody and SARS-CoV-2 neutralizing antibody. Although the overall rate of adverse effects was higher than the interim results from randomized controlled trials, our findings support the manufacturer’s reports about the high humoral immunogenicity of vaccine against COVID-19.Farhang BabamahmoodiMajid SaeediReza Alizadeh-NavaeiAkbar Hedayatizadeh-OmranSeyed Abbas MousaviGasem OvaiseShirafkan KordiZahra AkbariMazaher AzordehFatemeh AhangarkaniAhmad AlikhaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Farhang Babamahmoodi Majid Saeedi Reza Alizadeh-Navaei Akbar Hedayatizadeh-Omran Seyed Abbas Mousavi Gasem Ovaise Shirafkan Kordi Zahra Akbari Mazaher Azordeh Fatemeh Ahangarkani Ahmad Alikhani Side effects and Immunogenicity following administration of the Sputnik V COVID-19 vaccine in health care workers in Iran
description	Abstract The Sputnik V is a COVID- 19 vaccine developed by the Gamalia institute of epidemiology and microbiology and released on August 11, 2020. We provided independent evidence on side effects and immunogenicity following the administration of the Sputnik V COVID-19 in Iran. In this observational study, the healthcare workers who were vaccinated with the Sputnik V COVID-19 vaccine within February and April 2021 were evaluated. Among a total of 13,435 vaccinated healthcare workers, we received 3236 self-declaration reports of Sputnik V associated adverse events with the mean age 39.32 ± 10.19 years old which 38.8% were men and 61.2% were women. Totally 68.8% of females versus 66.2% of males reported side effects after receiving the first dose and 31.2% of females versus 33.8% of males reported side effects after the second dose of vaccine. The most common side effect was a pain in the injection site (56.9%), fatigue (50.9%), body pain (43.9%), headache (35.7%), fever (32.9%), joint pain (30.3%), chilling (29.8%) and drowsiness (20.3%). Side effects of the vaccine were significantly more frequent in females and younger individuals. Among a total of 238 participants, more than 90% after the first and second dose of vaccine had a detectable level of SARS-CoV-2 RBD antibody and SARS-CoV-2 neutralizing antibody. Although the overall rate of adverse effects was higher than the interim results from randomized controlled trials, our findings support the manufacturer’s reports about the high humoral immunogenicity of vaccine against COVID-19.
format	article
author	Farhang Babamahmoodi Majid Saeedi Reza Alizadeh-Navaei Akbar Hedayatizadeh-Omran Seyed Abbas Mousavi Gasem Ovaise Shirafkan Kordi Zahra Akbari Mazaher Azordeh Fatemeh Ahangarkani Ahmad Alikhani
author_facet	Farhang Babamahmoodi Majid Saeedi Reza Alizadeh-Navaei Akbar Hedayatizadeh-Omran Seyed Abbas Mousavi Gasem Ovaise Shirafkan Kordi Zahra Akbari Mazaher Azordeh Fatemeh Ahangarkani Ahmad Alikhani
author_sort	Farhang Babamahmoodi
title	Side effects and Immunogenicity following administration of the Sputnik V COVID-19 vaccine in health care workers in Iran
title_short	Side effects and Immunogenicity following administration of the Sputnik V COVID-19 vaccine in health care workers in Iran
title_full	Side effects and Immunogenicity following administration of the Sputnik V COVID-19 vaccine in health care workers in Iran
title_fullStr	Side effects and Immunogenicity following administration of the Sputnik V COVID-19 vaccine in health care workers in Iran
title_full_unstemmed	Side effects and Immunogenicity following administration of the Sputnik V COVID-19 vaccine in health care workers in Iran
title_sort	side effects and immunogenicity following administration of the sputnik v covid-19 vaccine in health care workers in iran
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0971570018154763af5766e40f50aa52
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Side effects and Immunogenicity following administration of the Sputnik V COVID-19 vaccine in health care workers in Iran

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