Influence of container structures and content solutions on dispensing time of ophthalmic solutions

Keiji Yoshikawa1, Hiroshi Yamada21Yoshikawa Eye Clinic, Tokyo, Japan; 2Santen Pharmaceutical Co., Ltd., Osaka, JapanPurpose: To investigate the influence of container structures and content solutions on the time of dispensing from eye dropper bottles.Methods: Eye dropper bottle models, solution mode...

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Autores principales:	Keiji Yoshikawa, Hiroshi Yamada
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/0978094c1b1a40fb84406508c1567089
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spelling	oai:doaj.org-article:0978094c1b1a40fb84406508c15670892021-12-02T06:22:19ZInfluence of container structures and content solutions on dispensing time of ophthalmic solutions1177-54671177-5483https://doaj.org/article/0978094c1b1a40fb84406508c15670892010-05-01T00:00:00Zhttp://www.dovepress.com/influence-of-container-structures-and-content-solutions-on-dispensing--a4461https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Keiji Yoshikawa1, Hiroshi Yamada21Yoshikawa Eye Clinic, Tokyo, Japan; 2Santen Pharmaceutical Co., Ltd., Osaka, JapanPurpose: To investigate the influence of container structures and content solutions on the time of dispensing from eye dropper bottles.Methods: Eye dropper bottle models, solution models (filtrate water/surfactant solution) and a dispensing time measuring apparatus were prepared to measure the dispensing time.Results: With filtrate water and pressure thrust load of 0.3 MPa, the dispensing time significantly increased from 1.1 &plusmn; 0.5 seconds to 4.6 &plusmn; 1.1 seconds depending on the decrease of inner aperture diameters from 0.4 mm to 0.2 mm (P &lt; 0.0001). When using the bottle models with inner aperture diameters of 0.4 mm or larger, the dispensing time became constant. The dispensing time using surfactant solution showed the same tendency as above. When pressure thrust load was large (0.07 MPa), the solution flew out continuously with inner aperture diameters of 0.4 mm or larger and the dispensing time could not be measured. The inner aperture diameter most strongly explained the variation of the dispensing time in both the content solutions in the multiple linear regression analysis (filtrate water: 46%, R2 = 0.462, surfactant solution: 56%, R2 = 0.563).Conclusions: Among content solutions and container structures, the dispensing time was mostly influenced by the diameter of the inner aperture of bottles.Keywords: dispensing time, model eye dropper bottle, model ophthalmic solution, nozzle internal space volume, nozzle inner aperture diameter Keiji YoshikawaHiroshi YamadaDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 481-486 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Keiji Yoshikawa Hiroshi Yamada Influence of container structures and content solutions on dispensing time of ophthalmic solutions
description	Keiji Yoshikawa1, Hiroshi Yamada21Yoshikawa Eye Clinic, Tokyo, Japan; 2Santen Pharmaceutical Co., Ltd., Osaka, JapanPurpose: To investigate the influence of container structures and content solutions on the time of dispensing from eye dropper bottles.Methods: Eye dropper bottle models, solution models (filtrate water/surfactant solution) and a dispensing time measuring apparatus were prepared to measure the dispensing time.Results: With filtrate water and pressure thrust load of 0.3 MPa, the dispensing time significantly increased from 1.1 &plusmn; 0.5 seconds to 4.6 &plusmn; 1.1 seconds depending on the decrease of inner aperture diameters from 0.4 mm to 0.2 mm (P &lt; 0.0001). When using the bottle models with inner aperture diameters of 0.4 mm or larger, the dispensing time became constant. The dispensing time using surfactant solution showed the same tendency as above. When pressure thrust load was large (0.07 MPa), the solution flew out continuously with inner aperture diameters of 0.4 mm or larger and the dispensing time could not be measured. The inner aperture diameter most strongly explained the variation of the dispensing time in both the content solutions in the multiple linear regression analysis (filtrate water: 46%, R2 = 0.462, surfactant solution: 56%, R2 = 0.563).Conclusions: Among content solutions and container structures, the dispensing time was mostly influenced by the diameter of the inner aperture of bottles.Keywords: dispensing time, model eye dropper bottle, model ophthalmic solution, nozzle internal space volume, nozzle inner aperture diameter
format	article
author	Keiji Yoshikawa Hiroshi Yamada
author_facet	Keiji Yoshikawa Hiroshi Yamada
author_sort	Keiji Yoshikawa
title	Influence of container structures and content solutions on dispensing time of ophthalmic solutions
title_short	Influence of container structures and content solutions on dispensing time of ophthalmic solutions
title_full	Influence of container structures and content solutions on dispensing time of ophthalmic solutions
title_fullStr	Influence of container structures and content solutions on dispensing time of ophthalmic solutions
title_full_unstemmed	Influence of container structures and content solutions on dispensing time of ophthalmic solutions
title_sort	influence of container structures and content solutions on dispensing time of ophthalmic solutions
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/0978094c1b1a40fb84406508c1567089
work_keys_str_mv	AT keijiyoshikawa influenceofcontainerstructuresandcontentsolutionsondispensingtimeofophthalmicsolutions AT hiroshiyamada influenceofcontainerstructuresandcontentsolutionsondispensingtimeofophthalmicsolutions
_version_	1718399914346545152

Influence of container structures and content solutions on dispensing time of ophthalmic solutions

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