A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica

Neuromyelitis optica (NMO) is a rare autoimmune condition characterized by inflammation and demyelination of the optic nerve and the spinal cord. Here, Estrada et al. identify NMO susceptibility variants in the MHC region and find that autoantibody-positive NMO genetically overlaps with lupus.

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Autores principales:	Karol Estrada, Christopher W. Whelan, Fengmei Zhao, Paola Bronson, Robert E. Handsaker, Chao Sun, John P. Carulli, Tim Harris, Richard M. Ransohoff, Steven A. McCarroll, Aaron G. Day-Williams, Benjamin M. Greenberg, Daniel G. MacArthur
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/097b3f04c35840e1a363fdf27d852415
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spelling	oai:doaj.org-article:097b3f04c35840e1a363fdf27d8524152021-12-02T16:49:50ZA whole-genome sequence study identifies genetic risk factors for neuromyelitis optica10.1038/s41467-018-04332-32041-1723https://doaj.org/article/097b3f04c35840e1a363fdf27d8524152018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04332-3https://doaj.org/toc/2041-1723Neuromyelitis optica (NMO) is a rare autoimmune condition characterized by inflammation and demyelination of the optic nerve and the spinal cord. Here, Estrada et al. identify NMO susceptibility variants in the MHC region and find that autoantibody-positive NMO genetically overlaps with lupus.Karol EstradaChristopher W. WhelanFengmei ZhaoPaola BronsonRobert E. HandsakerChao SunJohn P. CarulliTim HarrisRichard M. RansohoffSteven A. McCarrollAaron G. Day-WilliamsBenjamin M. GreenbergDaniel G. MacArthurNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karol Estrada Christopher W. Whelan Fengmei Zhao Paola Bronson Robert E. Handsaker Chao Sun John P. Carulli Tim Harris Richard M. Ransohoff Steven A. McCarroll Aaron G. Day-Williams Benjamin M. Greenberg Daniel G. MacArthur A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica
description	Neuromyelitis optica (NMO) is a rare autoimmune condition characterized by inflammation and demyelination of the optic nerve and the spinal cord. Here, Estrada et al. identify NMO susceptibility variants in the MHC region and find that autoantibody-positive NMO genetically overlaps with lupus.
format	article
author	Karol Estrada Christopher W. Whelan Fengmei Zhao Paola Bronson Robert E. Handsaker Chao Sun John P. Carulli Tim Harris Richard M. Ransohoff Steven A. McCarroll Aaron G. Day-Williams Benjamin M. Greenberg Daniel G. MacArthur
author_facet	Karol Estrada Christopher W. Whelan Fengmei Zhao Paola Bronson Robert E. Handsaker Chao Sun John P. Carulli Tim Harris Richard M. Ransohoff Steven A. McCarroll Aaron G. Day-Williams Benjamin M. Greenberg Daniel G. MacArthur
author_sort	Karol Estrada
title	A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica
title_short	A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica
title_full	A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica
title_fullStr	A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica
title_full_unstemmed	A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica
title_sort	whole-genome sequence study identifies genetic risk factors for neuromyelitis optica
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/097b3f04c35840e1a363fdf27d852415
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A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica

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