Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

SPI1 fusion genes in T-cell acute lymphoblastic leukemia (T-ALL) are commonly found with co-occurring NRAS mutations. Here, the authors show that the combination of these oncogenes is necessary to drive T-ALL in a murine model and that the oncogenic activity of the SPI1 fusion is dependent on β-cate...

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Autores principales: Quentin Van Thillo, Jolien De Bie, Janith A. Seneviratne, Sofie Demeyer, Sofia Omari, Anushree Balachandran, Vicki Zhai, Wai L. Tam, Bram Sweron, Ellen Geerdens, Olga Gielen, Sarah Provost, Heidi Segers, Nancy Boeckx, Glenn M. Marshall, Belamy B. Cheung, Kiyotaka Isobe, Itaru Kato, Junko Takita, Timothy G. Amos, Ira W. Deveson, Hannah McCalmont, Richard B. Lock, Ethan P. Oxley, Maximilian M. Garwood, Ross A. Dickins, Anne Uyttebroeck, Daniel R. Carter, Jan Cools, Charles E. de Bock
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/097bfb27edca4477bb37a09172ff1f71
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spelling oai:doaj.org-article:097bfb27edca4477bb37a09172ff1f712021-12-02T15:39:43ZOncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia10.1038/s41467-021-24442-92041-1723https://doaj.org/article/097bfb27edca4477bb37a09172ff1f712021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24442-9https://doaj.org/toc/2041-1723SPI1 fusion genes in T-cell acute lymphoblastic leukemia (T-ALL) are commonly found with co-occurring NRAS mutations. Here, the authors show that the combination of these oncogenes is necessary to drive T-ALL in a murine model and that the oncogenic activity of the SPI1 fusion is dependent on β-catenin.Quentin Van ThilloJolien De BieJanith A. SeneviratneSofie DemeyerSofia OmariAnushree BalachandranVicki ZhaiWai L. TamBram SweronEllen GeerdensOlga GielenSarah ProvostHeidi SegersNancy BoeckxGlenn M. MarshallBelamy B. CheungKiyotaka IsobeItaru KatoJunko TakitaTimothy G. AmosIra W. DevesonHannah McCalmontRichard B. LockEthan P. OxleyMaximilian M. GarwoodRoss A. DickinsAnne UyttebroeckDaniel R. CarterJan CoolsCharles E. de BockNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Quentin Van Thillo
Jolien De Bie
Janith A. Seneviratne
Sofie Demeyer
Sofia Omari
Anushree Balachandran
Vicki Zhai
Wai L. Tam
Bram Sweron
Ellen Geerdens
Olga Gielen
Sarah Provost
Heidi Segers
Nancy Boeckx
Glenn M. Marshall
Belamy B. Cheung
Kiyotaka Isobe
Itaru Kato
Junko Takita
Timothy G. Amos
Ira W. Deveson
Hannah McCalmont
Richard B. Lock
Ethan P. Oxley
Maximilian M. Garwood
Ross A. Dickins
Anne Uyttebroeck
Daniel R. Carter
Jan Cools
Charles E. de Bock
Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia
description SPI1 fusion genes in T-cell acute lymphoblastic leukemia (T-ALL) are commonly found with co-occurring NRAS mutations. Here, the authors show that the combination of these oncogenes is necessary to drive T-ALL in a murine model and that the oncogenic activity of the SPI1 fusion is dependent on β-catenin.
format article
author Quentin Van Thillo
Jolien De Bie
Janith A. Seneviratne
Sofie Demeyer
Sofia Omari
Anushree Balachandran
Vicki Zhai
Wai L. Tam
Bram Sweron
Ellen Geerdens
Olga Gielen
Sarah Provost
Heidi Segers
Nancy Boeckx
Glenn M. Marshall
Belamy B. Cheung
Kiyotaka Isobe
Itaru Kato
Junko Takita
Timothy G. Amos
Ira W. Deveson
Hannah McCalmont
Richard B. Lock
Ethan P. Oxley
Maximilian M. Garwood
Ross A. Dickins
Anne Uyttebroeck
Daniel R. Carter
Jan Cools
Charles E. de Bock
author_facet Quentin Van Thillo
Jolien De Bie
Janith A. Seneviratne
Sofie Demeyer
Sofia Omari
Anushree Balachandran
Vicki Zhai
Wai L. Tam
Bram Sweron
Ellen Geerdens
Olga Gielen
Sarah Provost
Heidi Segers
Nancy Boeckx
Glenn M. Marshall
Belamy B. Cheung
Kiyotaka Isobe
Itaru Kato
Junko Takita
Timothy G. Amos
Ira W. Deveson
Hannah McCalmont
Richard B. Lock
Ethan P. Oxley
Maximilian M. Garwood
Ross A. Dickins
Anne Uyttebroeck
Daniel R. Carter
Jan Cools
Charles E. de Bock
author_sort Quentin Van Thillo
title Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia
title_short Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia
title_full Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia
title_fullStr Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia
title_full_unstemmed Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia
title_sort oncogenic cooperation between tcf7-spi1 and nras(g12d) requires β-catenin activity to drive t-cell acute lymphoblastic leukemia
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/097bfb27edca4477bb37a09172ff1f71
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