Impact of idiopathic pulmonary fibrosis on clinical outcomes of lung cancer patients

Abstract The clinical characteristics of lung cancer in patients with idiopathic pulmonary fibrosis (IPF) differ from those of lung cancer in patients without IPF. Thus, we aimed to evaluate the impact of IPF on the clinical course of patients with lung cancer. Clinical data of IPF patients with lun...

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Autores principales:	Ho Cheol Kim, Seonjeong Lee, Jin Woo Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0984416dc2074842b2979c96d0ce10e6
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spelling	oai:doaj.org-article:0984416dc2074842b2979c96d0ce10e62021-12-02T15:51:13ZImpact of idiopathic pulmonary fibrosis on clinical outcomes of lung cancer patients10.1038/s41598-021-87747-12045-2322https://doaj.org/article/0984416dc2074842b2979c96d0ce10e62021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87747-1https://doaj.org/toc/2045-2322Abstract The clinical characteristics of lung cancer in patients with idiopathic pulmonary fibrosis (IPF) differ from those of lung cancer in patients without IPF. Thus, we aimed to evaluate the impact of IPF on the clinical course of patients with lung cancer. Clinical data of IPF patients with lung cancer (n = 122) were compared with those of patients with lung cancer without IPF (n = 488) matched by age, sex, histopathology, stage, and date of diagnosis of lung cancer. The median follow-up period after diagnosis of lung cancer was 16 months. Among patients with IPF, the mean age was 68 years, 95.9% were male, 93.2% were ever-smokers, and squamous cell carcinoma was the most common cancer type (48.4%). The IPF group had poorer lung function and lower lobe predominance of lung cancer than the no-IPF group. The IPF group showed a poorer prognosis than the no-IPF group (5-year survival rate: 14.5% vs. 30.1%, respectively; P < 0.001), even after adjusting for lung function and regardless of the treatment method. Among patients with IPF, 16.8% experienced acute exacerbation within 1 month after treatment of lung cancer. The treatment outcome of patients with lung cancer and IPF was generally unfavorable, and acute exacerbation triggered by treatment frequently occurred.Ho Cheol KimSeonjeong LeeJin Woo SongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ho Cheol Kim Seonjeong Lee Jin Woo Song Impact of idiopathic pulmonary fibrosis on clinical outcomes of lung cancer patients
description	Abstract The clinical characteristics of lung cancer in patients with idiopathic pulmonary fibrosis (IPF) differ from those of lung cancer in patients without IPF. Thus, we aimed to evaluate the impact of IPF on the clinical course of patients with lung cancer. Clinical data of IPF patients with lung cancer (n = 122) were compared with those of patients with lung cancer without IPF (n = 488) matched by age, sex, histopathology, stage, and date of diagnosis of lung cancer. The median follow-up period after diagnosis of lung cancer was 16 months. Among patients with IPF, the mean age was 68 years, 95.9% were male, 93.2% were ever-smokers, and squamous cell carcinoma was the most common cancer type (48.4%). The IPF group had poorer lung function and lower lobe predominance of lung cancer than the no-IPF group. The IPF group showed a poorer prognosis than the no-IPF group (5-year survival rate: 14.5% vs. 30.1%, respectively; P < 0.001), even after adjusting for lung function and regardless of the treatment method. Among patients with IPF, 16.8% experienced acute exacerbation within 1 month after treatment of lung cancer. The treatment outcome of patients with lung cancer and IPF was generally unfavorable, and acute exacerbation triggered by treatment frequently occurred.
format	article
author	Ho Cheol Kim Seonjeong Lee Jin Woo Song
author_facet	Ho Cheol Kim Seonjeong Lee Jin Woo Song
author_sort	Ho Cheol Kim
title	Impact of idiopathic pulmonary fibrosis on clinical outcomes of lung cancer patients
title_short	Impact of idiopathic pulmonary fibrosis on clinical outcomes of lung cancer patients
title_full	Impact of idiopathic pulmonary fibrosis on clinical outcomes of lung cancer patients
title_fullStr	Impact of idiopathic pulmonary fibrosis on clinical outcomes of lung cancer patients
title_full_unstemmed	Impact of idiopathic pulmonary fibrosis on clinical outcomes of lung cancer patients
title_sort	impact of idiopathic pulmonary fibrosis on clinical outcomes of lung cancer patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0984416dc2074842b2979c96d0ce10e6
work_keys_str_mv	AT hocheolkim impactofidiopathicpulmonaryfibrosisonclinicaloutcomesoflungcancerpatients AT seonjeonglee impactofidiopathicpulmonaryfibrosisonclinicaloutcomesoflungcancerpatients AT jinwoosong impactofidiopathicpulmonaryfibrosisonclinicaloutcomesoflungcancerpatients
_version_	1718385612544802816

Impact of idiopathic pulmonary fibrosis on clinical outcomes of lung cancer patients

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