Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating Animal Studies

Syed Abdullah Alkaff, 1 Krishna Radhakrishnan, 1 Anu Maashaa Nedumaran, 1 Ping Liao, 2 Bertrand Czarny 1, 3 1School of Materials Science and Engineering, Nanyang Technological University 639798, Singapore; 2Calcium Signalling Laboratory, National Neuroscience Institute 308433, Singapore; 3Lee Kon...

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Autores principales:	Alkaff SA, Radhakrishnan K, Nedumaran AM, Liao P, Czarny B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	nanoparticle drug delivery system stroke animal model nano medicine therapeutics Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/09845ea5166c44c680f130b5e37f95f1
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spelling	oai:doaj.org-article:09845ea5166c44c680f130b5e37f95f12021-12-02T04:34:59ZNanocarriers for Stroke Therapy: Advances and Obstacles in Translating Animal Studies1178-2013https://doaj.org/article/09845ea5166c44c680f130b5e37f95f12020-01-01T00:00:00Zhttps://www.dovepress.com/nanocarriers-for-stroke-therapy-advances-and-obstacles-in-translating--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Syed Abdullah Alkaff, 1 Krishna Radhakrishnan, 1 Anu Maashaa Nedumaran, 1 Ping Liao, 2 Bertrand Czarny 1, 3 1School of Materials Science and Engineering, Nanyang Technological University 639798, Singapore; 2Calcium Signalling Laboratory, National Neuroscience Institute 308433, Singapore; 3Lee Kong Chian School of Medicine, Nanyang Technological University 639798, SingaporeCorrespondence: Bertrand CzarnySchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Ave, Block N4.1, #02-17 639798, SingaporeTel +65 67904613Email bczarny@ntu.edu.sgAbstract: The technology of drug delivery systems (DDS) has expanded into many applications, such as for treating neurological disorders. Nanoparticle DDS offer a unique strategy for targeted transport and improved outcomes of therapeutics. Stroke is likely to benefit from the emergence of this technology though clinical breakthroughs are yet to manifest. This review explores the recent advances in this field and provides insight on the trends, prospects and challenges of translating this technology to clinical application. Carriers of diverse material compositions are presented, with special focus on the surface properties and emphasis on the similarities and inconsistencies among in vivo experimental paradigms. Research attention is scattered among various nanoparticle DDS and various routes of drug administration, which expresses the lack of consistency among studies. Analysis of current literature reveals lipid- and polymer-based DDS as forerunners of DDS for stroke; however, cell membrane-derived vesicles (CMVs) possess the competitive edge due to their innate biocompatibility and superior efficacy. Conversely, inorganic and carbon-based DDS offer different functionalities as well as varied capacity for loading but suffer mainly from poor safety and general lack of investigation in this area. This review supports the existing literature by systematizing presently available data and accounting for the differences in drugs of choice, carrier types, animal models, intervention strategies and outcome parameters.Keywords: nanoparticle, drug delivery system, stroke, animal model, nano medicine, therapeuticsAlkaff SARadhakrishnan KNedumaran AMLiao PCzarny BDove Medical Pressarticlenanoparticledrug delivery systemstrokeanimal modelnano medicinetherapeuticsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 445-464 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoparticle drug delivery system stroke animal model nano medicine therapeutics Medicine (General) R5-920
spellingShingle	nanoparticle drug delivery system stroke animal model nano medicine therapeutics Medicine (General) R5-920 Alkaff SA Radhakrishnan K Nedumaran AM Liao P Czarny B Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating Animal Studies
description	Syed Abdullah Alkaff, 1 Krishna Radhakrishnan, 1 Anu Maashaa Nedumaran, 1 Ping Liao, 2 Bertrand Czarny 1, 3 1School of Materials Science and Engineering, Nanyang Technological University 639798, Singapore; 2Calcium Signalling Laboratory, National Neuroscience Institute 308433, Singapore; 3Lee Kong Chian School of Medicine, Nanyang Technological University 639798, SingaporeCorrespondence: Bertrand CzarnySchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Ave, Block N4.1, #02-17 639798, SingaporeTel +65 67904613Email bczarny@ntu.edu.sgAbstract: The technology of drug delivery systems (DDS) has expanded into many applications, such as for treating neurological disorders. Nanoparticle DDS offer a unique strategy for targeted transport and improved outcomes of therapeutics. Stroke is likely to benefit from the emergence of this technology though clinical breakthroughs are yet to manifest. This review explores the recent advances in this field and provides insight on the trends, prospects and challenges of translating this technology to clinical application. Carriers of diverse material compositions are presented, with special focus on the surface properties and emphasis on the similarities and inconsistencies among in vivo experimental paradigms. Research attention is scattered among various nanoparticle DDS and various routes of drug administration, which expresses the lack of consistency among studies. Analysis of current literature reveals lipid- and polymer-based DDS as forerunners of DDS for stroke; however, cell membrane-derived vesicles (CMVs) possess the competitive edge due to their innate biocompatibility and superior efficacy. Conversely, inorganic and carbon-based DDS offer different functionalities as well as varied capacity for loading but suffer mainly from poor safety and general lack of investigation in this area. This review supports the existing literature by systematizing presently available data and accounting for the differences in drugs of choice, carrier types, animal models, intervention strategies and outcome parameters.Keywords: nanoparticle, drug delivery system, stroke, animal model, nano medicine, therapeutics
format	article
author	Alkaff SA Radhakrishnan K Nedumaran AM Liao P Czarny B
author_facet	Alkaff SA Radhakrishnan K Nedumaran AM Liao P Czarny B
author_sort	Alkaff SA
title	Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating Animal Studies
title_short	Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating Animal Studies
title_full	Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating Animal Studies
title_fullStr	Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating Animal Studies
title_full_unstemmed	Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating Animal Studies
title_sort	nanocarriers for stroke therapy: advances and obstacles in translating animal studies
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/09845ea5166c44c680f130b5e37f95f1
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Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating Animal Studies

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