Unraveling heme detoxification in the malaria parasite by in situ correlative X-ray fluorescence microscopy and soft X-ray tomography

Abstract A key drug target for malaria has been the detoxification pathway of the iron-containing molecule heme, which is the toxic byproduct of hemoglobin digestion. The cornerstone of heme detoxification is its sequestration into hemozoin crystals, but how this occurs remains uncertain. We report...

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Autores principales: Sergey Kapishnikov, Daniel Grolimund, Gerd Schneider, Eva Pereiro, James G. McNally, Jens Als-Nielsen, Leslie Leiserowitz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/0985f7d76d7140ed84de25c8f8e8ac97
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