Interaction of the pioneer transcription factor GATA3 with nucleosomes

GATA 3 functions as a pioneer factor during cellular reprogramming. Here the authors delineate nucleosome positioning relative to GATA3 binding motifs and describe the structure of a GATA3–nucleosome complex; providing insight into how a pioneer factor interacts with nucleosomes and catalyze their l...

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Auteurs principaux: Hiroki Tanaka, Yoshimasa Takizawa, Motoki Takaku, Daiki Kato, Yusuke Kumagawa, Sara A. Grimm, Paul A. Wade, Hitoshi Kurumizaka
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/0988b7bf33a24b96b0b7da5d742055b0
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spelling oai:doaj.org-article:0988b7bf33a24b96b0b7da5d742055b02021-12-02T18:01:15ZInteraction of the pioneer transcription factor GATA3 with nucleosomes10.1038/s41467-020-17959-y2041-1723https://doaj.org/article/0988b7bf33a24b96b0b7da5d742055b02020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17959-yhttps://doaj.org/toc/2041-1723GATA 3 functions as a pioneer factor during cellular reprogramming. Here the authors delineate nucleosome positioning relative to GATA3 binding motifs and describe the structure of a GATA3–nucleosome complex; providing insight into how a pioneer factor interacts with nucleosomes and catalyze their local remodelling to produce an accessible enhancer.Hiroki TanakaYoshimasa TakizawaMotoki TakakuDaiki KatoYusuke KumagawaSara A. GrimmPaul A. WadeHitoshi KurumizakaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hiroki Tanaka
Yoshimasa Takizawa
Motoki Takaku
Daiki Kato
Yusuke Kumagawa
Sara A. Grimm
Paul A. Wade
Hitoshi Kurumizaka
Interaction of the pioneer transcription factor GATA3 with nucleosomes
description GATA 3 functions as a pioneer factor during cellular reprogramming. Here the authors delineate nucleosome positioning relative to GATA3 binding motifs and describe the structure of a GATA3–nucleosome complex; providing insight into how a pioneer factor interacts with nucleosomes and catalyze their local remodelling to produce an accessible enhancer.
format article
author Hiroki Tanaka
Yoshimasa Takizawa
Motoki Takaku
Daiki Kato
Yusuke Kumagawa
Sara A. Grimm
Paul A. Wade
Hitoshi Kurumizaka
author_facet Hiroki Tanaka
Yoshimasa Takizawa
Motoki Takaku
Daiki Kato
Yusuke Kumagawa
Sara A. Grimm
Paul A. Wade
Hitoshi Kurumizaka
author_sort Hiroki Tanaka
title Interaction of the pioneer transcription factor GATA3 with nucleosomes
title_short Interaction of the pioneer transcription factor GATA3 with nucleosomes
title_full Interaction of the pioneer transcription factor GATA3 with nucleosomes
title_fullStr Interaction of the pioneer transcription factor GATA3 with nucleosomes
title_full_unstemmed Interaction of the pioneer transcription factor GATA3 with nucleosomes
title_sort interaction of the pioneer transcription factor gata3 with nucleosomes
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/0988b7bf33a24b96b0b7da5d742055b0
work_keys_str_mv AT hirokitanaka interactionofthepioneertranscriptionfactorgata3withnucleosomes
AT yoshimasatakizawa interactionofthepioneertranscriptionfactorgata3withnucleosomes
AT motokitakaku interactionofthepioneertranscriptionfactorgata3withnucleosomes
AT daikikato interactionofthepioneertranscriptionfactorgata3withnucleosomes
AT yusukekumagawa interactionofthepioneertranscriptionfactorgata3withnucleosomes
AT saraagrimm interactionofthepioneertranscriptionfactorgata3withnucleosomes
AT paulawade interactionofthepioneertranscriptionfactorgata3withnucleosomes
AT hitoshikurumizaka interactionofthepioneertranscriptionfactorgata3withnucleosomes
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