Interaction of the pioneer transcription factor GATA3 with nucleosomes

GATA 3 functions as a pioneer factor during cellular reprogramming. Here the authors delineate nucleosome positioning relative to GATA3 binding motifs and describe the structure of a GATA3–nucleosome complex; providing insight into how a pioneer factor interacts with nucleosomes and catalyze their l...

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Autores principales:	Hiroki Tanaka, Yoshimasa Takizawa, Motoki Takaku, Daiki Kato, Yusuke Kumagawa, Sara A. Grimm, Paul A. Wade, Hitoshi Kurumizaka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0988b7bf33a24b96b0b7da5d742055b0
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spelling	oai:doaj.org-article:0988b7bf33a24b96b0b7da5d742055b02021-12-02T18:01:15ZInteraction of the pioneer transcription factor GATA3 with nucleosomes10.1038/s41467-020-17959-y2041-1723https://doaj.org/article/0988b7bf33a24b96b0b7da5d742055b02020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17959-yhttps://doaj.org/toc/2041-1723GATA 3 functions as a pioneer factor during cellular reprogramming. Here the authors delineate nucleosome positioning relative to GATA3 binding motifs and describe the structure of a GATA3–nucleosome complex; providing insight into how a pioneer factor interacts with nucleosomes and catalyze their local remodelling to produce an accessible enhancer.Hiroki TanakaYoshimasa TakizawaMotoki TakakuDaiki KatoYusuke KumagawaSara A. GrimmPaul A. WadeHitoshi KurumizakaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroki Tanaka Yoshimasa Takizawa Motoki Takaku Daiki Kato Yusuke Kumagawa Sara A. Grimm Paul A. Wade Hitoshi Kurumizaka Interaction of the pioneer transcription factor GATA3 with nucleosomes
description	GATA 3 functions as a pioneer factor during cellular reprogramming. Here the authors delineate nucleosome positioning relative to GATA3 binding motifs and describe the structure of a GATA3–nucleosome complex; providing insight into how a pioneer factor interacts with nucleosomes and catalyze their local remodelling to produce an accessible enhancer.
format	article
author	Hiroki Tanaka Yoshimasa Takizawa Motoki Takaku Daiki Kato Yusuke Kumagawa Sara A. Grimm Paul A. Wade Hitoshi Kurumizaka
author_facet	Hiroki Tanaka Yoshimasa Takizawa Motoki Takaku Daiki Kato Yusuke Kumagawa Sara A. Grimm Paul A. Wade Hitoshi Kurumizaka
author_sort	Hiroki Tanaka
title	Interaction of the pioneer transcription factor GATA3 with nucleosomes
title_short	Interaction of the pioneer transcription factor GATA3 with nucleosomes
title_full	Interaction of the pioneer transcription factor GATA3 with nucleosomes
title_fullStr	Interaction of the pioneer transcription factor GATA3 with nucleosomes
title_full_unstemmed	Interaction of the pioneer transcription factor GATA3 with nucleosomes
title_sort	interaction of the pioneer transcription factor gata3 with nucleosomes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0988b7bf33a24b96b0b7da5d742055b0
work_keys_str_mv	AT hirokitanaka interactionofthepioneertranscriptionfactorgata3withnucleosomes AT yoshimasatakizawa interactionofthepioneertranscriptionfactorgata3withnucleosomes AT motokitakaku interactionofthepioneertranscriptionfactorgata3withnucleosomes AT daikikato interactionofthepioneertranscriptionfactorgata3withnucleosomes AT yusukekumagawa interactionofthepioneertranscriptionfactorgata3withnucleosomes AT saraagrimm interactionofthepioneertranscriptionfactorgata3withnucleosomes AT paulawade interactionofthepioneertranscriptionfactorgata3withnucleosomes AT hitoshikurumizaka interactionofthepioneertranscriptionfactorgata3withnucleosomes
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Interaction of the pioneer transcription factor GATA3 with nucleosomes

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