The Impact of Frailty on Prognosis in Elderly Hemodialysis Patients: A Prospective Cohort Study

Yuanyuan Li,1,&ast; Dai Zhang,1,&ast; Qing Ma,1 Zongli Diao,2 Sha Liu,2 Xiaotian Shi1 1Department of Geriatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, B...

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Autores principales:	Li Y, Zhang D, Ma Q, Diao Z, Liu S, Shi X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	elderly people frailty hemodialysis mortality emergency visits hospitalizations Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/09940ab24b0f4d9fa87623fa2df1c6b2
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spelling	oai:doaj.org-article:09940ab24b0f4d9fa87623fa2df1c6b22021-12-02T17:42:13ZThe Impact of Frailty on Prognosis in Elderly Hemodialysis Patients: A Prospective Cohort Study1178-1998https://doaj.org/article/09940ab24b0f4d9fa87623fa2df1c6b22021-09-01T00:00:00Zhttps://www.dovepress.com/the-impact-of-frailty-on-prognosis-in-elderly-hemodialysis-patients-a--peer-reviewed-fulltext-article-CIAhttps://doaj.org/toc/1178-1998Yuanyuan Li,1,&ast; Dai Zhang,1,&ast; Qing Ma,1 Zongli Diao,2 Sha Liu,2 Xiaotian Shi1 1Department of Geriatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qing MaDepartment of Geriatrics, Beijing Friendship Hospital, Capital Medical University, No. 95, Yong’an Road, Xicheng District, Beijing, 100050, People’s Republic of ChinaTel +86 10 63137641Fax +86 10 63138730Email maqing@ccmu.edu.cnPurpose: To explore the impact of frailty on adverse outcomes in elderly hemodialysis (HD) patients.Patients and Methods: An observational and prospective cohort study was conducted in elderly patients (≥ 60) with HD, with an average 12-month follow-up. Fried frailty phenotype (FFP) was used to define frailty. Negative binomial regression was used to estimate the impact of frailty on the incidence of emergency visits, hospitalizations, acute cardiovascular events, and falls within a year. Cox regression analysis was used to assess the influence of frailty on all-cause mortality in elderly HD patients.Results: Our study enrolled 150 elderly HD patients, and the prevalence of frailty was 34.7%. After adjustment, frailty was independently associated with increased all-cause mortality [hazard ratio (HR)=4.10, 95% CI: 1.09– 15.43, p=0.037] and emergency visits [incidence rate ratio (IRR)=2.78 95% CI: 1.70– 4.60, p< 0.001]. Gait speed was an independent risk factor for all-cause deaths (HR=5.56 95% CI: 1.41– 22.00, p=0.014), emergency visits (IRR=2.52 95% CI: 1.48– 4.33, p< 0.001), and hospitalizations (IRR=2.24, 95% CI: 1.19– 4.21, p=0.010) in elderly HD patients.Conclusion: Frailty was an independent indicator of all-cause mortality and emergency visits in elderly patients with HD.Keywords: elderly people, frailty, hemodialysis, mortality, emergency visits, hospitalizationsLi YZhang DMa QDiao ZLiu SShi XDove Medical Pressarticleelderly peoplefrailtyhemodialysismortalityemergency visitshospitalizationsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 1659-1667 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	elderly people frailty hemodialysis mortality emergency visits hospitalizations Geriatrics RC952-954.6
spellingShingle	elderly people frailty hemodialysis mortality emergency visits hospitalizations Geriatrics RC952-954.6 Li Y Zhang D Ma Q Diao Z Liu S Shi X The Impact of Frailty on Prognosis in Elderly Hemodialysis Patients: A Prospective Cohort Study
description	Yuanyuan Li,1,&ast; Dai Zhang,1,&ast; Qing Ma,1 Zongli Diao,2 Sha Liu,2 Xiaotian Shi1 1Department of Geriatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qing MaDepartment of Geriatrics, Beijing Friendship Hospital, Capital Medical University, No. 95, Yong’an Road, Xicheng District, Beijing, 100050, People’s Republic of ChinaTel +86 10 63137641Fax +86 10 63138730Email maqing@ccmu.edu.cnPurpose: To explore the impact of frailty on adverse outcomes in elderly hemodialysis (HD) patients.Patients and Methods: An observational and prospective cohort study was conducted in elderly patients (≥ 60) with HD, with an average 12-month follow-up. Fried frailty phenotype (FFP) was used to define frailty. Negative binomial regression was used to estimate the impact of frailty on the incidence of emergency visits, hospitalizations, acute cardiovascular events, and falls within a year. Cox regression analysis was used to assess the influence of frailty on all-cause mortality in elderly HD patients.Results: Our study enrolled 150 elderly HD patients, and the prevalence of frailty was 34.7%. After adjustment, frailty was independently associated with increased all-cause mortality [hazard ratio (HR)=4.10, 95% CI: 1.09– 15.43, p=0.037] and emergency visits [incidence rate ratio (IRR)=2.78 95% CI: 1.70– 4.60, p< 0.001]. Gait speed was an independent risk factor for all-cause deaths (HR=5.56 95% CI: 1.41– 22.00, p=0.014), emergency visits (IRR=2.52 95% CI: 1.48– 4.33, p< 0.001), and hospitalizations (IRR=2.24, 95% CI: 1.19– 4.21, p=0.010) in elderly HD patients.Conclusion: Frailty was an independent indicator of all-cause mortality and emergency visits in elderly patients with HD.Keywords: elderly people, frailty, hemodialysis, mortality, emergency visits, hospitalizations
format	article
author	Li Y Zhang D Ma Q Diao Z Liu S Shi X
author_facet	Li Y Zhang D Ma Q Diao Z Liu S Shi X
author_sort	Li Y
title	The Impact of Frailty on Prognosis in Elderly Hemodialysis Patients: A Prospective Cohort Study
title_short	The Impact of Frailty on Prognosis in Elderly Hemodialysis Patients: A Prospective Cohort Study
title_full	The Impact of Frailty on Prognosis in Elderly Hemodialysis Patients: A Prospective Cohort Study
title_fullStr	The Impact of Frailty on Prognosis in Elderly Hemodialysis Patients: A Prospective Cohort Study
title_full_unstemmed	The Impact of Frailty on Prognosis in Elderly Hemodialysis Patients: A Prospective Cohort Study
title_sort	impact of frailty on prognosis in elderly hemodialysis patients: a prospective cohort study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/09940ab24b0f4d9fa87623fa2df1c6b2
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The Impact of Frailty on Prognosis in Elderly Hemodialysis Patients: A Prospective Cohort Study

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