Immunohistochemical Expression of Cyclin D1 and PIN1 in Endometrial Carcinoma

Background: Cyclin D1, a positive regular of the cell cycle, may lead to uncontrolled cell proliferation. Overexpression of Cyclin D1 has been associated with the diagnosis and prognosis of numerous tumors. PIN1 binds and isomerizes the phosphorylated serine/threonine–proline motif, which lead to al...

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Autores principales:	Shimaa Abu_Seadah, Samah Attiah, Mohamed Ali
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	keywords: endometrial carcinoma immunohistochemistry cyclin d1 pin1 prognostic markers Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/09955c57d16e44c9b6ab5b2c41ed55ab
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spelling	oai:doaj.org-article:09955c57d16e44c9b6ab5b2c41ed55ab2021-12-02T10:46:43ZImmunohistochemical Expression of Cyclin D1 and PIN1 in Endometrial Carcinoma2636-41742682-378010.21608/ijma.2020.43269.1174https://doaj.org/article/09955c57d16e44c9b6ab5b2c41ed55ab2021-01-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_120304_78e6cdf38d8335fee152e744e4a65e4e.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Cyclin D1, a positive regular of the cell cycle, may lead to uncontrolled cell proliferation. Overexpression of Cyclin D1 has been associated with the diagnosis and prognosis of numerous tumors. PIN1 binds and isomerizes the phosphorylated serine/threonine–proline motif, which lead to alteration in the structure and function of proteins. The altered phosphorylated proteins by PIN1 are closely linked to development of cancer. PIN1 is strongly expressed in the majority of tumors, suggesting it promotes tumorigenesis, and negatively associated with the clinical prognosis. Objectives: To assess Cyclin D1 & PIN1 expression and correlation in endometrial adenocarcinoma. Also to assess the relationship between Cyclin D1 & PIN1 expression and clinico-pathological variables of cases of endometrial carcinoma.Materials and Methods: Study included 30 cases of endometrial adenocarcinoma specimens. Immunohistochemical staining was performed for both Cyclin D1 and PIN1. Blocks of tumor tissue and clinical data were gathered from the files of Pathology Department of Al-Zahraa University Hospital, between July 2017 and October 2019. Results: Cyclin D1 positive expression and PIN1 high expression were increased significantly with age, high clinical stage, high pathological grade and more myometrium invasion depth. Cyclin D1 expression was positively associated with PIN1 expression (P-value = 0.004).Conclusions: Cyclin D1 & PIN1 expression associated with age, stage, grade and depth of myometrial wall invasion in patients with endometrial carcinoma. The overexpression of Cyclin D1 & PIN1 seems to indicate a more malignant phenotype of endometrial carcinoma.Shimaa Abu_SeadahSamah AttiahMohamed AliAl-Azhar University, Faculty of Medicine (Damietta)articlekeywords: endometrial carcinomaimmunohistochemistrycyclin d1pin1prognostic markersMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 1, Pp 984-994 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	keywords: endometrial carcinoma immunohistochemistry cyclin d1 pin1 prognostic markers Medicine (General) R5-920
spellingShingle	keywords: endometrial carcinoma immunohistochemistry cyclin d1 pin1 prognostic markers Medicine (General) R5-920 Shimaa Abu_Seadah Samah Attiah Mohamed Ali Immunohistochemical Expression of Cyclin D1 and PIN1 in Endometrial Carcinoma
description	Background: Cyclin D1, a positive regular of the cell cycle, may lead to uncontrolled cell proliferation. Overexpression of Cyclin D1 has been associated with the diagnosis and prognosis of numerous tumors. PIN1 binds and isomerizes the phosphorylated serine/threonine–proline motif, which lead to alteration in the structure and function of proteins. The altered phosphorylated proteins by PIN1 are closely linked to development of cancer. PIN1 is strongly expressed in the majority of tumors, suggesting it promotes tumorigenesis, and negatively associated with the clinical prognosis. Objectives: To assess Cyclin D1 & PIN1 expression and correlation in endometrial adenocarcinoma. Also to assess the relationship between Cyclin D1 & PIN1 expression and clinico-pathological variables of cases of endometrial carcinoma.Materials and Methods: Study included 30 cases of endometrial adenocarcinoma specimens. Immunohistochemical staining was performed for both Cyclin D1 and PIN1. Blocks of tumor tissue and clinical data were gathered from the files of Pathology Department of Al-Zahraa University Hospital, between July 2017 and October 2019. Results: Cyclin D1 positive expression and PIN1 high expression were increased significantly with age, high clinical stage, high pathological grade and more myometrium invasion depth. Cyclin D1 expression was positively associated with PIN1 expression (P-value = 0.004).Conclusions: Cyclin D1 & PIN1 expression associated with age, stage, grade and depth of myometrial wall invasion in patients with endometrial carcinoma. The overexpression of Cyclin D1 & PIN1 seems to indicate a more malignant phenotype of endometrial carcinoma.
format	article
author	Shimaa Abu_Seadah Samah Attiah Mohamed Ali
author_facet	Shimaa Abu_Seadah Samah Attiah Mohamed Ali
author_sort	Shimaa Abu_Seadah
title	Immunohistochemical Expression of Cyclin D1 and PIN1 in Endometrial Carcinoma
title_short	Immunohistochemical Expression of Cyclin D1 and PIN1 in Endometrial Carcinoma
title_full	Immunohistochemical Expression of Cyclin D1 and PIN1 in Endometrial Carcinoma
title_fullStr	Immunohistochemical Expression of Cyclin D1 and PIN1 in Endometrial Carcinoma
title_full_unstemmed	Immunohistochemical Expression of Cyclin D1 and PIN1 in Endometrial Carcinoma
title_sort	immunohistochemical expression of cyclin d1 and pin1 in endometrial carcinoma
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/09955c57d16e44c9b6ab5b2c41ed55ab
work_keys_str_mv	AT shimaaabuseadah immunohistochemicalexpressionofcyclind1andpin1inendometrialcarcinoma AT samahattiah immunohistochemicalexpressionofcyclind1andpin1inendometrialcarcinoma AT mohamedali immunohistochemicalexpressionofcyclind1andpin1inendometrialcarcinoma
_version_	1718396688933060608

Immunohistochemical Expression of Cyclin D1 and PIN1 in Endometrial Carcinoma

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