Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks

Disease risk variants can exert their influence on phenotypes by altering epigenome function. Here, Pelikan et al. show that variants inducing allelic imbalance in histone marks in lymphoblastoid cell lines from lupus patients are enriched in autoimmune disease haplotypes and influence gene expressi...

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Autores principales:	Richard C. Pelikan, Jennifer A. Kelly, Yao Fu, Caleb A. Lareau, Kandice L. Tessneer, Graham B. Wiley, Mandi M. Wiley, Stuart B. Glenn, John B. Harley, Joel M. Guthridge, Judith A. James, Martin J. Aryee, Courtney Montgomery, Patrick M. Gaffney
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0996b48baa6642459f605c36bd0e9936
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spelling	oai:doaj.org-article:0996b48baa6642459f605c36bd0e99362021-12-02T14:38:51ZEnhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks10.1038/s41467-018-05328-92041-1723https://doaj.org/article/0996b48baa6642459f605c36bd0e99362018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05328-9https://doaj.org/toc/2041-1723Disease risk variants can exert their influence on phenotypes by altering epigenome function. Here, Pelikan et al. show that variants inducing allelic imbalance in histone marks in lymphoblastoid cell lines from lupus patients are enriched in autoimmune disease haplotypes and influence gene expression.Richard C. PelikanJennifer A. KellyYao FuCaleb A. LareauKandice L. TessneerGraham B. WileyMandi M. WileyStuart B. GlennJohn B. HarleyJoel M. GuthridgeJudith A. JamesMartin J. AryeeCourtney MontgomeryPatrick M. GaffneyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Richard C. Pelikan Jennifer A. Kelly Yao Fu Caleb A. Lareau Kandice L. Tessneer Graham B. Wiley Mandi M. Wiley Stuart B. Glenn John B. Harley Joel M. Guthridge Judith A. James Martin J. Aryee Courtney Montgomery Patrick M. Gaffney Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks
description	Disease risk variants can exert their influence on phenotypes by altering epigenome function. Here, Pelikan et al. show that variants inducing allelic imbalance in histone marks in lymphoblastoid cell lines from lupus patients are enriched in autoimmune disease haplotypes and influence gene expression.
format	article
author	Richard C. Pelikan Jennifer A. Kelly Yao Fu Caleb A. Lareau Kandice L. Tessneer Graham B. Wiley Mandi M. Wiley Stuart B. Glenn John B. Harley Joel M. Guthridge Judith A. James Martin J. Aryee Courtney Montgomery Patrick M. Gaffney
author_facet	Richard C. Pelikan Jennifer A. Kelly Yao Fu Caleb A. Lareau Kandice L. Tessneer Graham B. Wiley Mandi M. Wiley Stuart B. Glenn John B. Harley Joel M. Guthridge Judith A. James Martin J. Aryee Courtney Montgomery Patrick M. Gaffney
author_sort	Richard C. Pelikan
title	Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks
title_short	Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks
title_full	Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks
title_fullStr	Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks
title_full_unstemmed	Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks
title_sort	enhancer histone-qtls are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0996b48baa6642459f605c36bd0e9936
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Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks

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