A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.

Hepatitis B (HBV) infection is endemic in Viet Nam, with up to 8.4 million individuals estimated to be chronically infected. We describe results of a large, multicentre seroepidemiological and molecular study of the prevalence of HBV infection and blood-borne viral coinfections in Viet Nam. Individu...

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Autores principales:	Linda Dunford, Michael J Carr, Jonathan Dean, Linh Thuy Nguyen, Thu Hong Ta Thi, Binh Thanh Nguyen, Jeff Connell, Suzie Coughlan, Hien Tran Nguyen, William W Hall, Lan Anh Nguyen Thi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0999ed88b3944df992a64c5bf38fc5c6
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spelling	oai:doaj.org-article:0999ed88b3944df992a64c5bf38fc5c62021-11-18T07:15:34ZA multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.1932-620310.1371/journal.pone.0039027https://doaj.org/article/0999ed88b3944df992a64c5bf38fc5c62012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22720022/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Hepatitis B (HBV) infection is endemic in Viet Nam, with up to 8.4 million individuals estimated to be chronically infected. We describe results of a large, multicentre seroepidemiological and molecular study of the prevalence of HBV infection and blood-borne viral coinfections in Viet Nam. Individuals with varying risk factors for infection (n = 8654) were recruited from five centres; Ha Noi, Hai Phong, Da Nang, Khanh Hoa and Can Tho. A mean prevalence rate of 10.7% was observed and levels of HBsAg were significantly higher in injecting drug users (IDUs) (17.4%, n = 174/1000) and dialysis patients (14.3%, n = 82/575) than in lower-risk groups (9.4%; p<0.001). Coinfection with HIV was seen in 28% of HBV-infected IDUs (n = 49/174) and 15.2% of commercial sex workers (CSWs; n = 15/99). HCV infection was present in 89.8% of the HBV-HIV coinfected IDUs (n = 44/49) and 40% of HBV-HIV coinfected CSWs (n = 16/40). Anti-HDV was detected in 10.7% (n = 34/318) of HBsAg positive individuals. Phylogenetic analysis of HBV S gene (n = 187) showed a predominance of genotype B4 (82.6%); genotypes C1 (14.6%), B2 (2.7%) and C5 (0.5%) were also identified. The precore mutation G1896A was identified in 35% of all specimens, and was more frequently observed in genotype B (41%) than genotype C (3%; p<0.0001). In the immunodominant 'a' region of the surface gene, point mutations were identified in 31% (n = 58/187) of sequences, and 2.2% (n = 4/187) and 5.3% (n = 10/187) specimens contained the major vaccine escape mutations G145A/R and P120L/Q/S/T, respectively. 368 HBsAg positive individuals were genotyped for the IL28B SNP rs12979860 and no significant association between the IL28B SNP and clearance of HBsAg, HBV viral load or HBeAg was observed. This study confirms the high prevalence of HBV infection in Viet Nam and also highlights the significant levels of blood-borne virus coinfections, which have important implications for hepatitis-related morbidity and development of effective management strategies.Linda DunfordMichael J CarrJonathan DeanLinh Thuy NguyenThu Hong Ta ThiBinh Thanh NguyenJeff ConnellSuzie CoughlanHien Tran NguyenWilliam W HallLan Anh Nguyen ThiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e39027 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Linda Dunford Michael J Carr Jonathan Dean Linh Thuy Nguyen Thu Hong Ta Thi Binh Thanh Nguyen Jeff Connell Suzie Coughlan Hien Tran Nguyen William W Hall Lan Anh Nguyen Thi A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
description	Hepatitis B (HBV) infection is endemic in Viet Nam, with up to 8.4 million individuals estimated to be chronically infected. We describe results of a large, multicentre seroepidemiological and molecular study of the prevalence of HBV infection and blood-borne viral coinfections in Viet Nam. Individuals with varying risk factors for infection (n = 8654) were recruited from five centres; Ha Noi, Hai Phong, Da Nang, Khanh Hoa and Can Tho. A mean prevalence rate of 10.7% was observed and levels of HBsAg were significantly higher in injecting drug users (IDUs) (17.4%, n = 174/1000) and dialysis patients (14.3%, n = 82/575) than in lower-risk groups (9.4%; p<0.001). Coinfection with HIV was seen in 28% of HBV-infected IDUs (n = 49/174) and 15.2% of commercial sex workers (CSWs; n = 15/99). HCV infection was present in 89.8% of the HBV-HIV coinfected IDUs (n = 44/49) and 40% of HBV-HIV coinfected CSWs (n = 16/40). Anti-HDV was detected in 10.7% (n = 34/318) of HBsAg positive individuals. Phylogenetic analysis of HBV S gene (n = 187) showed a predominance of genotype B4 (82.6%); genotypes C1 (14.6%), B2 (2.7%) and C5 (0.5%) were also identified. The precore mutation G1896A was identified in 35% of all specimens, and was more frequently observed in genotype B (41%) than genotype C (3%; p<0.0001). In the immunodominant 'a' region of the surface gene, point mutations were identified in 31% (n = 58/187) of sequences, and 2.2% (n = 4/187) and 5.3% (n = 10/187) specimens contained the major vaccine escape mutations G145A/R and P120L/Q/S/T, respectively. 368 HBsAg positive individuals were genotyped for the IL28B SNP rs12979860 and no significant association between the IL28B SNP and clearance of HBsAg, HBV viral load or HBeAg was observed. This study confirms the high prevalence of HBV infection in Viet Nam and also highlights the significant levels of blood-borne virus coinfections, which have important implications for hepatitis-related morbidity and development of effective management strategies.
format	article
author	Linda Dunford Michael J Carr Jonathan Dean Linh Thuy Nguyen Thu Hong Ta Thi Binh Thanh Nguyen Jeff Connell Suzie Coughlan Hien Tran Nguyen William W Hall Lan Anh Nguyen Thi
author_facet	Linda Dunford Michael J Carr Jonathan Dean Linh Thuy Nguyen Thu Hong Ta Thi Binh Thanh Nguyen Jeff Connell Suzie Coughlan Hien Tran Nguyen William W Hall Lan Anh Nguyen Thi
author_sort	Linda Dunford
title	A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
title_short	A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
title_full	A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
title_fullStr	A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
title_full_unstemmed	A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
title_sort	multicentre molecular analysis of hepatitis b and blood-borne virus coinfections in viet nam.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0999ed88b3944df992a64c5bf38fc5c6
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A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.

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