Raptor regulates functional maturation of murine beta cells

Raptor regulates functional maturation of murine beta cells

mTORC1 regulates beta cell survival, function and adaptation to physiologic and pathological stimuli. Here Niet al. demonstrate that that deficiency of Raptor, a component of mTORC1 complex, impairs insulin secretion and glucose tolerance in mice by affecting maturation of beta cells during the post...

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Autores principales: Qicheng Ni, Yanyun Gu, Yun Xie, Qinglei Yin, Hongli Zhang, Aifang Nie, Wenyi Li, Yanqiu Wang, Guang Ning, Weiqing Wang, Qidi Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/099a0854987d44c98d83cefc6c22936b
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spelling oai:doaj.org-article:099a0854987d44c98d83cefc6c22936b2021-12-02T14:40:23ZRaptor regulates functional maturation of murine beta cells10.1038/ncomms157552041-1723https://doaj.org/article/099a0854987d44c98d83cefc6c22936b2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15755https://doaj.org/toc/2041-1723mTORC1 regulates beta cell survival, function and adaptation to physiologic and pathological stimuli. Here Niet al. demonstrate that that deficiency of Raptor, a component of mTORC1 complex, impairs insulin secretion and glucose tolerance in mice by affecting maturation of beta cells during the postnatal period.Qicheng NiYanyun GuYun XieQinglei YinHongli ZhangAifang NieWenyi LiYanqiu WangGuang NingWeiqing WangQidi WangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Qicheng Ni
Yanyun Gu
Yun Xie
Qinglei Yin
Hongli Zhang
Aifang Nie
Wenyi Li
Yanqiu Wang
Guang Ning
Weiqing Wang
Qidi Wang
Raptor regulates functional maturation of murine beta cells
description mTORC1 regulates beta cell survival, function and adaptation to physiologic and pathological stimuli. Here Niet al. demonstrate that that deficiency of Raptor, a component of mTORC1 complex, impairs insulin secretion and glucose tolerance in mice by affecting maturation of beta cells during the postnatal period.
format article
author Qicheng Ni
Yanyun Gu
Yun Xie
Qinglei Yin
Hongli Zhang
Aifang Nie
Wenyi Li
Yanqiu Wang
Guang Ning
Weiqing Wang
Qidi Wang
author_facet Qicheng Ni
Yanyun Gu
Yun Xie
Qinglei Yin
Hongli Zhang
Aifang Nie
Wenyi Li
Yanqiu Wang
Guang Ning
Weiqing Wang
Qidi Wang
author_sort Qicheng Ni
title Raptor regulates functional maturation of murine beta cells
title_short Raptor regulates functional maturation of murine beta cells
title_full Raptor regulates functional maturation of murine beta cells
title_fullStr Raptor regulates functional maturation of murine beta cells
title_full_unstemmed Raptor regulates functional maturation of murine beta cells
title_sort raptor regulates functional maturation of murine beta cells
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/099a0854987d44c98d83cefc6c22936b
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