Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

The diversity of fibroblasts contributing to wound healing is unclear. Here, the authors use single-cell RNA-sequencing to identify heterogeneity among murine fibroblasts in the wound and find that recruited myeloid cells contribute to adipocyte regeneration during healing.

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Autores principales:	Christian F. Guerrero-Juarez, Priya H. Dedhia, Suoqin Jin, Rolando Ruiz-Vega, Dennis Ma, Yuchen Liu, Kosuke Yamaga, Olga Shestova, Denise L. Gay, Zaixin Yang, Kai Kessenbrock, Qing Nie, Warren S. Pear, George Cotsarelis, Maksim V. Plikus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/099a0aa5ccec4a9394fa9efe30aa4c89
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spelling	oai:doaj.org-article:099a0aa5ccec4a9394fa9efe30aa4c892021-12-02T16:57:52ZSingle-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds10.1038/s41467-018-08247-x2041-1723https://doaj.org/article/099a0aa5ccec4a9394fa9efe30aa4c892019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08247-xhttps://doaj.org/toc/2041-1723The diversity of fibroblasts contributing to wound healing is unclear. Here, the authors use single-cell RNA-sequencing to identify heterogeneity among murine fibroblasts in the wound and find that recruited myeloid cells contribute to adipocyte regeneration during healing.Christian F. Guerrero-JuarezPriya H. DedhiaSuoqin JinRolando Ruiz-VegaDennis MaYuchen LiuKosuke YamagaOlga ShestovaDenise L. GayZaixin YangKai KessenbrockQing NieWarren S. PearGeorge CotsarelisMaksim V. PlikusNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christian F. Guerrero-Juarez Priya H. Dedhia Suoqin Jin Rolando Ruiz-Vega Dennis Ma Yuchen Liu Kosuke Yamaga Olga Shestova Denise L. Gay Zaixin Yang Kai Kessenbrock Qing Nie Warren S. Pear George Cotsarelis Maksim V. Plikus Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds
description	The diversity of fibroblasts contributing to wound healing is unclear. Here, the authors use single-cell RNA-sequencing to identify heterogeneity among murine fibroblasts in the wound and find that recruited myeloid cells contribute to adipocyte regeneration during healing.
format	article
author	Christian F. Guerrero-Juarez Priya H. Dedhia Suoqin Jin Rolando Ruiz-Vega Dennis Ma Yuchen Liu Kosuke Yamaga Olga Shestova Denise L. Gay Zaixin Yang Kai Kessenbrock Qing Nie Warren S. Pear George Cotsarelis Maksim V. Plikus
author_facet	Christian F. Guerrero-Juarez Priya H. Dedhia Suoqin Jin Rolando Ruiz-Vega Dennis Ma Yuchen Liu Kosuke Yamaga Olga Shestova Denise L. Gay Zaixin Yang Kai Kessenbrock Qing Nie Warren S. Pear George Cotsarelis Maksim V. Plikus
author_sort	Christian F. Guerrero-Juarez
title	Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds
title_short	Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds
title_full	Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds
title_fullStr	Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds
title_full_unstemmed	Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds
title_sort	single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/099a0aa5ccec4a9394fa9efe30aa4c89
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Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

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