A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages

Diphtheria toxin selectively kills cells engineered to express the diphtheria toxin receptor (DTR). Here the authors report a PEGylated version of diphtheria toxin that does not enter the brain, allowing for ablation of only peripheral cells when using Cre lines that drive DTR expression in both the...

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Autores principales:	Mafalda M. A. Pereira, Inês Mahú, Elsa Seixas, Noelia Martinéz-Sánchez, Nadiya Kubasova, Roksana M Pirzgalska, Paul Cohen, Marcelo O Dietrich, Miguel López, Gonçalo J. L. Bernardes, Ana I. Domingos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/099c5bb8f4474bd5b3c2689e765318cb
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spelling	oai:doaj.org-article:099c5bb8f4474bd5b3c2689e765318cb2021-12-02T14:42:27ZA brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages10.1038/ncomms149672041-1723https://doaj.org/article/099c5bb8f4474bd5b3c2689e765318cb2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14967https://doaj.org/toc/2041-1723Diphtheria toxin selectively kills cells engineered to express the diphtheria toxin receptor (DTR). Here the authors report a PEGylated version of diphtheria toxin that does not enter the brain, allowing for ablation of only peripheral cells when using Cre lines that drive DTR expression in both the periphery and in the brain.Mafalda M. A. PereiraInês MahúElsa SeixasNoelia Martinéz-SánchezNadiya KubasovaRoksana M PirzgalskaPaul CohenMarcelo O DietrichMiguel LópezGonçalo J. L. BernardesAna I. DomingosNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mafalda M. A. Pereira Inês Mahú Elsa Seixas Noelia Martinéz-Sánchez Nadiya Kubasova Roksana M Pirzgalska Paul Cohen Marcelo O Dietrich Miguel López Gonçalo J. L. Bernardes Ana I. Domingos A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages
description	Diphtheria toxin selectively kills cells engineered to express the diphtheria toxin receptor (DTR). Here the authors report a PEGylated version of diphtheria toxin that does not enter the brain, allowing for ablation of only peripheral cells when using Cre lines that drive DTR expression in both the periphery and in the brain.
format	article
author	Mafalda M. A. Pereira Inês Mahú Elsa Seixas Noelia Martinéz-Sánchez Nadiya Kubasova Roksana M Pirzgalska Paul Cohen Marcelo O Dietrich Miguel López Gonçalo J. L. Bernardes Ana I. Domingos
author_facet	Mafalda M. A. Pereira Inês Mahú Elsa Seixas Noelia Martinéz-Sánchez Nadiya Kubasova Roksana M Pirzgalska Paul Cohen Marcelo O Dietrich Miguel López Gonçalo J. L. Bernardes Ana I. Domingos
author_sort	Mafalda M. A. Pereira
title	A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages
title_short	A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages
title_full	A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages
title_fullStr	A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages
title_full_unstemmed	A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages
title_sort	brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/099c5bb8f4474bd5b3c2689e765318cb
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A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages

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