Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis

Atherosclerosis is characterized by subendothelial lipid retention believed to be the result of endothelial trancytosis. Here, the authors show that endothelium can take up and process LDL, generating cholesterol crystals that are deposited on the basolateral side of the cells, causing their dysfunc...

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Autores principales:	Yvonne Baumer, Sara McCurdy, Tina M. Weatherby, Nehal N. Mehta, Stefan Halbherr, Pascal Halbherr, Noboru Yamazaki, William A. Boisvert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/09a229c662fe4fe4a530175d5d4ee89e
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spelling	oai:doaj.org-article:09a229c662fe4fe4a530175d5d4ee89e2021-12-02T14:41:19ZHyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis10.1038/s41467-017-01186-z2041-1723https://doaj.org/article/09a229c662fe4fe4a530175d5d4ee89e2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01186-zhttps://doaj.org/toc/2041-1723Atherosclerosis is characterized by subendothelial lipid retention believed to be the result of endothelial trancytosis. Here, the authors show that endothelium can take up and process LDL, generating cholesterol crystals that are deposited on the basolateral side of the cells, causing their dysfunction that can be prevented by forskolin/rolipram treatment.Yvonne BaumerSara McCurdyTina M. WeatherbyNehal N. MehtaStefan HalbherrPascal HalbherrNoboru YamazakiWilliam A. BoisvertNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yvonne Baumer Sara McCurdy Tina M. Weatherby Nehal N. Mehta Stefan Halbherr Pascal Halbherr Noboru Yamazaki William A. Boisvert Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis
description	Atherosclerosis is characterized by subendothelial lipid retention believed to be the result of endothelial trancytosis. Here, the authors show that endothelium can take up and process LDL, generating cholesterol crystals that are deposited on the basolateral side of the cells, causing their dysfunction that can be prevented by forskolin/rolipram treatment.
format	article
author	Yvonne Baumer Sara McCurdy Tina M. Weatherby Nehal N. Mehta Stefan Halbherr Pascal Halbherr Noboru Yamazaki William A. Boisvert
author_facet	Yvonne Baumer Sara McCurdy Tina M. Weatherby Nehal N. Mehta Stefan Halbherr Pascal Halbherr Noboru Yamazaki William A. Boisvert
author_sort	Yvonne Baumer
title	Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis
title_short	Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis
title_full	Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis
title_fullStr	Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis
title_full_unstemmed	Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis
title_sort	hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/09a229c662fe4fe4a530175d5d4ee89e
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Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis

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