Efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis

The article presents the data of the randomized clinical trial of 80 young patients with destructive pulmonary tuberculosis for various methods of TB drugs injection. Particular attention is paid to the role of parenteral drug delivery. The work demonstrated that newly diagnosed patients with destru...

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Autores principales:	I. A. Morozov, V. Y. Mishin, A. V. Mishina, A. L. Sobkin, V. A. Guseva, D. D. Petrov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	tuberculosis drug-resistant of mycobacterium tuberculosis tb drugs methods of drug injection Science Q
Acceso en línea:	https://doaj.org/article/09a3c19ea30741b082b27b1f619646e0
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spelling	oai:doaj.org-article:09a3c19ea30741b082b27b1f619646e02021-11-23T06:14:35ZEfficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis2541-94202587-959610.12737/23347https://doaj.org/article/09a3c19ea30741b082b27b1f619646e02016-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/274https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The article presents the data of the randomized clinical trial of 80 young patients with destructive pulmonary tuberculosis for various methods of TB drugs injection. Particular attention is paid to the role of parenteral drug delivery. The work demonstrated that newly diagnosed patients with destructive pulmonary tuberculosis of younger age the most optimal and effective is parenteral injection of injectable forms of TB drugs, allowing to halt bacterioexcretion for 3 months in 92.5 % of cases and to close cavities in the lungs in 80 %. In newly diagnosed patients with destructive pulmonary tuberculosis of young age oral use of tablets and of TB drugs is not effective enough, allowing to achieve 3 months cessation of bacterial isolation in 85.2 % of cases and to close cavities in the lungs in 42.5 %. Undesirable side reactions to parenteral administration of injectable forms of TB drugs were detected in 17.5 % of patients and to separate oral tablet forms - in 20 %, fatal reactions were observed in 5 % of cases of drug delivery regardless of method.I. A. MorozovV. Y. MishinA. V. MishinaA. L. SobkinV. A. GusevaD. D. PetrovScientific Сentre for Family Health and Human Reproduction Problemsarticletuberculosisdrug-resistant of mycobacterium tuberculosistb drugsmethods of drug injectionScienceQRUActa Biomedica Scientifica, Vol 1, Iss 5, Pp 35-39 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	tuberculosis drug-resistant of mycobacterium tuberculosis tb drugs methods of drug injection Science Q
spellingShingle	tuberculosis drug-resistant of mycobacterium tuberculosis tb drugs methods of drug injection Science Q I. A. Morozov V. Y. Mishin A. V. Mishina A. L. Sobkin V. A. Guseva D. D. Petrov Efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis
description	The article presents the data of the randomized clinical trial of 80 young patients with destructive pulmonary tuberculosis for various methods of TB drugs injection. Particular attention is paid to the role of parenteral drug delivery. The work demonstrated that newly diagnosed patients with destructive pulmonary tuberculosis of younger age the most optimal and effective is parenteral injection of injectable forms of TB drugs, allowing to halt bacterioexcretion for 3 months in 92.5 % of cases and to close cavities in the lungs in 80 %. In newly diagnosed patients with destructive pulmonary tuberculosis of young age oral use of tablets and of TB drugs is not effective enough, allowing to achieve 3 months cessation of bacterial isolation in 85.2 % of cases and to close cavities in the lungs in 42.5 %. Undesirable side reactions to parenteral administration of injectable forms of TB drugs were detected in 17.5 % of patients and to separate oral tablet forms - in 20 %, fatal reactions were observed in 5 % of cases of drug delivery regardless of method.
format	article
author	I. A. Morozov V. Y. Mishin A. V. Mishina A. L. Sobkin V. A. Guseva D. D. Petrov
author_facet	I. A. Morozov V. Y. Mishin A. V. Mishina A. L. Sobkin V. A. Guseva D. D. Petrov
author_sort	I. A. Morozov
title	Efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis
title_short	Efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis
title_full	Efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis
title_fullStr	Efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis
title_full_unstemmed	Efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis
title_sort	efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/09a3c19ea30741b082b27b1f619646e0
work_keys_str_mv	AT iamorozov efficiencyofvariousmethodsofinjectionofantituberculosisagentsinyoungpatientswithdestructivepulmonarytuberculosis AT vymishin efficiencyofvariousmethodsofinjectionofantituberculosisagentsinyoungpatientswithdestructivepulmonarytuberculosis AT avmishina efficiencyofvariousmethodsofinjectionofantituberculosisagentsinyoungpatientswithdestructivepulmonarytuberculosis AT alsobkin efficiencyofvariousmethodsofinjectionofantituberculosisagentsinyoungpatientswithdestructivepulmonarytuberculosis AT vaguseva efficiencyofvariousmethodsofinjectionofantituberculosisagentsinyoungpatientswithdestructivepulmonarytuberculosis AT ddpetrov efficiencyofvariousmethodsofinjectionofantituberculosisagentsinyoungpatientswithdestructivepulmonarytuberculosis
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Efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis

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