Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features

CTCF mediates long-range chromatin interactions which are important for genome organization and function. Here, the authors demonstrate that CTCF-mediated interactome exhibits extensive plasticity and present Lollipop, a machine-learning framework which predicts CTCF-mediated long-range interactions...

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Autores principales:	Yan Kai, Jaclyn Andricovich, Zhouhao Zeng, Jun Zhu, Alexandros Tzatsos, Weiqun Peng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/09a575151e5e4ef0b2ce4b14003d0c4c
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spelling	oai:doaj.org-article:09a575151e5e4ef0b2ce4b14003d0c4c2021-12-02T15:34:15ZPredicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features10.1038/s41467-018-06664-62041-1723https://doaj.org/article/09a575151e5e4ef0b2ce4b14003d0c4c2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06664-6https://doaj.org/toc/2041-1723CTCF mediates long-range chromatin interactions which are important for genome organization and function. Here, the authors demonstrate that CTCF-mediated interactome exhibits extensive plasticity and present Lollipop, a machine-learning framework which predicts CTCF-mediated long-range interactions using genomic and epigenomic features.Yan KaiJaclyn AndricovichZhouhao ZengJun ZhuAlexandros TzatsosWeiqun PengNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yan Kai Jaclyn Andricovich Zhouhao Zeng Jun Zhu Alexandros Tzatsos Weiqun Peng Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features
description	CTCF mediates long-range chromatin interactions which are important for genome organization and function. Here, the authors demonstrate that CTCF-mediated interactome exhibits extensive plasticity and present Lollipop, a machine-learning framework which predicts CTCF-mediated long-range interactions using genomic and epigenomic features.
format	article
author	Yan Kai Jaclyn Andricovich Zhouhao Zeng Jun Zhu Alexandros Tzatsos Weiqun Peng
author_facet	Yan Kai Jaclyn Andricovich Zhouhao Zeng Jun Zhu Alexandros Tzatsos Weiqun Peng
author_sort	Yan Kai
title	Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features
title_short	Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features
title_full	Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features
title_fullStr	Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features
title_full_unstemmed	Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features
title_sort	predicting ctcf-mediated chromatin interactions by integrating genomic and epigenomic features
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/09a575151e5e4ef0b2ce4b14003d0c4c
work_keys_str_mv	AT yankai predictingctcfmediatedchromatininteractionsbyintegratinggenomicandepigenomicfeatures AT jaclynandricovich predictingctcfmediatedchromatininteractionsbyintegratinggenomicandepigenomicfeatures AT zhouhaozeng predictingctcfmediatedchromatininteractionsbyintegratinggenomicandepigenomicfeatures AT junzhu predictingctcfmediatedchromatininteractionsbyintegratinggenomicandepigenomicfeatures AT alexandrostzatsos predictingctcfmediatedchromatininteractionsbyintegratinggenomicandepigenomicfeatures AT weiqunpeng predictingctcfmediatedchromatininteractionsbyintegratinggenomicandepigenomicfeatures
_version_	1718386881696104448

Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features

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