Enhanced ANGPTL2 expression in adipose tissues and its association with insulin resistance in obese women

Abstract Angiopoietin-like protein 2 has been proposed to be a key mediator linking obesity and insulin resistance. However, no detailed study of ANGPTL2 expression in human adipose tissues has yet been reported. To investigate the pattern and regulation of ANGPTL2 expression in human adipose tissue...

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Autores principales:	Jimin Kim, Seul Ki Lee, Yeon Jin Jang, Hye Soon Park, Jong-Hyeok Kim, Joon Pio Hong, Yeon Ji Lee, Yoon-Suk Heo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Angptl4 Expression Angptl4 mRNA Obese Adipose Tissue Angiopoietin-like Protein MMP-9 mRNA Medicine R Science Q
Acceso en línea:	https://doaj.org/article/09a8e2e2c98445e58b7be05dc83c9b78
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spelling	oai:doaj.org-article:09a8e2e2c98445e58b7be05dc83c9b782021-12-02T15:07:46ZEnhanced ANGPTL2 expression in adipose tissues and its association with insulin resistance in obese women10.1038/s41598-018-32419-w2045-2322https://doaj.org/article/09a8e2e2c98445e58b7be05dc83c9b782018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32419-whttps://doaj.org/toc/2045-2322Abstract Angiopoietin-like protein 2 has been proposed to be a key mediator linking obesity and insulin resistance. However, no detailed study of ANGPTL2 expression in human adipose tissues has yet been reported. To investigate the pattern and regulation of ANGPTL2 expression in human adipose tissues in obesity and its related diseases, we recruited 32 non-diabetic and 13 type 2 diabetic obese women and 32 normal-weight women. ANGPTL2 mRNA was expressed at a similar level in visceral and subcutaneous adipose tissues. Adipose tissue ANGPTL2 mRNA was much higher in obese patients. Adipose tissue ANGPTL2 mRNA and serum ANGPTL2 levels showed strong associations with metabolic parameters associated with insulin resistance. In adipose tissue, ANGPTL2 mRNA was closely correlated with the expression of genes involved in inflammation and ER stress. ANGPTL2 mRNA was principally expressed in adipocytes, and its expression was markedly higher in the adipocyte but non-adipocyte fraction of obese adipose tissues. Culture of human adipocytes under conditions mimicking the microenvironment of obese adipose tissue (especially, increased ER stress) stimulated ANGPTL2 gene expression and secretion. In addition, co-culture of adipocytes and macrophages suggested that ANGPTL2 excessively produced by adipocytes, may contribute inflammation and remodeling in obese adipose tissues, thereby promoting insulin resistance.Jimin KimSeul Ki LeeYeon Jin JangHye Soon ParkJong-Hyeok KimJoon Pio HongYeon Ji LeeYoon-Suk HeoNature PortfolioarticleAngptl4 ExpressionAngptl4 mRNAObese Adipose TissueAngiopoietin-like ProteinMMP-9 mRNAMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Angptl4 Expression Angptl4 mRNA Obese Adipose Tissue Angiopoietin-like Protein MMP-9 mRNA Medicine R Science Q
spellingShingle	Angptl4 Expression Angptl4 mRNA Obese Adipose Tissue Angiopoietin-like Protein MMP-9 mRNA Medicine R Science Q Jimin Kim Seul Ki Lee Yeon Jin Jang Hye Soon Park Jong-Hyeok Kim Joon Pio Hong Yeon Ji Lee Yoon-Suk Heo Enhanced ANGPTL2 expression in adipose tissues and its association with insulin resistance in obese women
description	Abstract Angiopoietin-like protein 2 has been proposed to be a key mediator linking obesity and insulin resistance. However, no detailed study of ANGPTL2 expression in human adipose tissues has yet been reported. To investigate the pattern and regulation of ANGPTL2 expression in human adipose tissues in obesity and its related diseases, we recruited 32 non-diabetic and 13 type 2 diabetic obese women and 32 normal-weight women. ANGPTL2 mRNA was expressed at a similar level in visceral and subcutaneous adipose tissues. Adipose tissue ANGPTL2 mRNA was much higher in obese patients. Adipose tissue ANGPTL2 mRNA and serum ANGPTL2 levels showed strong associations with metabolic parameters associated with insulin resistance. In adipose tissue, ANGPTL2 mRNA was closely correlated with the expression of genes involved in inflammation and ER stress. ANGPTL2 mRNA was principally expressed in adipocytes, and its expression was markedly higher in the adipocyte but non-adipocyte fraction of obese adipose tissues. Culture of human adipocytes under conditions mimicking the microenvironment of obese adipose tissue (especially, increased ER stress) stimulated ANGPTL2 gene expression and secretion. In addition, co-culture of adipocytes and macrophages suggested that ANGPTL2 excessively produced by adipocytes, may contribute inflammation and remodeling in obese adipose tissues, thereby promoting insulin resistance.
format	article
author	Jimin Kim Seul Ki Lee Yeon Jin Jang Hye Soon Park Jong-Hyeok Kim Joon Pio Hong Yeon Ji Lee Yoon-Suk Heo
author_facet	Jimin Kim Seul Ki Lee Yeon Jin Jang Hye Soon Park Jong-Hyeok Kim Joon Pio Hong Yeon Ji Lee Yoon-Suk Heo
author_sort	Jimin Kim
title	Enhanced ANGPTL2 expression in adipose tissues and its association with insulin resistance in obese women
title_short	Enhanced ANGPTL2 expression in adipose tissues and its association with insulin resistance in obese women
title_full	Enhanced ANGPTL2 expression in adipose tissues and its association with insulin resistance in obese women
title_fullStr	Enhanced ANGPTL2 expression in adipose tissues and its association with insulin resistance in obese women
title_full_unstemmed	Enhanced ANGPTL2 expression in adipose tissues and its association with insulin resistance in obese women
title_sort	enhanced angptl2 expression in adipose tissues and its association with insulin resistance in obese women
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/09a8e2e2c98445e58b7be05dc83c9b78
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Enhanced ANGPTL2 expression in adipose tissues and its association with insulin resistance in obese women

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