Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

Antitumor T cells can be inhibited by a TGFβ rich tumor microenvironment. The authors develop bifunctional proteins comprising CTLA-4 or PD-L1 immune checkpoint-targeted antibodies fused to a “TGFβ trap” and show that they counteract tumor immune tolerance and enhance the efficacy of these antibodie...

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Autores principales:	Rajani Ravi, Kimberly A. Noonan, Vui Pham, Rishi Bedi, Alex Zhavoronkov, Ivan V. Ozerov, Eugene Makarev, Artem V. Artemov, Piotr T. Wysocki, Ranee Mehra, Sridhar Nimmagadda, Luigi Marchionni, David Sidransky, Ivan M. Borrello, Evgeny Izumchenko, Atul Bedi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/09ab3fbc9c154b9e985f7d27f5620315
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:09ab3fbc9c154b9e985f7d27f56203152021-12-02T17:33:04ZBifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy10.1038/s41467-017-02696-62041-1723https://doaj.org/article/09ab3fbc9c154b9e985f7d27f56203152018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02696-6https://doaj.org/toc/2041-1723Antitumor T cells can be inhibited by a TGFβ rich tumor microenvironment. The authors develop bifunctional proteins comprising CTLA-4 or PD-L1 immune checkpoint-targeted antibodies fused to a “TGFβ trap” and show that they counteract tumor immune tolerance and enhance the efficacy of these antibodies.Rajani RaviKimberly A. NoonanVui PhamRishi BediAlex ZhavoronkovIvan V. OzerovEugene MakarevArtem V. ArtemovPiotr T. WysockiRanee MehraSridhar NimmagaddaLuigi MarchionniDavid SidranskyIvan M. BorrelloEvgeny IzumchenkoAtul BediNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rajani Ravi Kimberly A. Noonan Vui Pham Rishi Bedi Alex Zhavoronkov Ivan V. Ozerov Eugene Makarev Artem V. Artemov Piotr T. Wysocki Ranee Mehra Sridhar Nimmagadda Luigi Marchionni David Sidransky Ivan M. Borrello Evgeny Izumchenko Atul Bedi Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy
description	Antitumor T cells can be inhibited by a TGFβ rich tumor microenvironment. The authors develop bifunctional proteins comprising CTLA-4 or PD-L1 immune checkpoint-targeted antibodies fused to a “TGFβ trap” and show that they counteract tumor immune tolerance and enhance the efficacy of these antibodies.
format	article
author	Rajani Ravi Kimberly A. Noonan Vui Pham Rishi Bedi Alex Zhavoronkov Ivan V. Ozerov Eugene Makarev Artem V. Artemov Piotr T. Wysocki Ranee Mehra Sridhar Nimmagadda Luigi Marchionni David Sidransky Ivan M. Borrello Evgeny Izumchenko Atul Bedi
author_facet	Rajani Ravi Kimberly A. Noonan Vui Pham Rishi Bedi Alex Zhavoronkov Ivan V. Ozerov Eugene Makarev Artem V. Artemov Piotr T. Wysocki Ranee Mehra Sridhar Nimmagadda Luigi Marchionni David Sidransky Ivan M. Borrello Evgeny Izumchenko Atul Bedi
author_sort	Rajani Ravi
title	Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy
title_short	Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy
title_full	Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy
title_fullStr	Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy
title_full_unstemmed	Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy
title_sort	bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable tgfβ enhance the efficacy of cancer immunotherapy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/09ab3fbc9c154b9e985f7d27f5620315
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Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

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