Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?

One of the major clinical manifestations of peripheral neuropathy, either resulting from trauma or diseases, is chronic pain. While it significantly impacts patients’ quality of life, the underlying mechanisms remain elusive, and treatment is not satisfactory. Systemic chronic inflammation (SCI) tha...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wen Bo Sam Zhou, JingWen Meng, Ji Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	systemic chronic inflammation chronic pain psychological disorders systemic modulation peripheral neuropathy cytokines Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/09aed24c44ce45ce839586318738e9ba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:09aed24c44ce45ce839586318738e9ba
record_format	dspace
spelling	oai:doaj.org-article:09aed24c44ce45ce839586318738e9ba2021-11-10T08:20:40ZDoes Low Grade Systemic Inflammation Have a Role in Chronic Pain?1662-509910.3389/fnmol.2021.785214https://doaj.org/article/09aed24c44ce45ce839586318738e9ba2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnmol.2021.785214/fullhttps://doaj.org/toc/1662-5099One of the major clinical manifestations of peripheral neuropathy, either resulting from trauma or diseases, is chronic pain. While it significantly impacts patients’ quality of life, the underlying mechanisms remain elusive, and treatment is not satisfactory. Systemic chronic inflammation (SCI) that we are referring to in this perspective is a state of low-grade, persistent, non-infective inflammation, being found in many physiological and pathological conditions. Distinct from acute inflammation, which is a protective process fighting against intruders, SCI might have harmful effects. It has been associated with many chronic non-communicable diseases. We hypothesize that SCI could be a predisposing and/or precipitating factor in the development of chronic pain, as well as associated comorbidities. We reviewed evidence from human clinical studies indicating the coexistence of SCI with various types of chronic pain. We also collated existing data about the sources of SCI and who could have it, showing that those individuals or patients having SCI usually have higher prevalence of chronic pain and psychological comorbidities. We thus elaborate on the need for further research in the connection between SCI and chronic pain. Several hypotheses have been proposed to explain these complex interactions.Wen Bo Sam ZhouWen Bo Sam ZhouJingWen MengJingWen MengJi ZhangJi ZhangJi ZhangFrontiers Media S.A.articlesystemic chronic inflammationchronic painpsychological disorderssystemic modulationperipheral neuropathycytokinesNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Molecular Neuroscience, Vol 14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	systemic chronic inflammation chronic pain psychological disorders systemic modulation peripheral neuropathy cytokines Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	systemic chronic inflammation chronic pain psychological disorders systemic modulation peripheral neuropathy cytokines Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Wen Bo Sam Zhou Wen Bo Sam Zhou JingWen Meng JingWen Meng Ji Zhang Ji Zhang Ji Zhang Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?
description	One of the major clinical manifestations of peripheral neuropathy, either resulting from trauma or diseases, is chronic pain. While it significantly impacts patients’ quality of life, the underlying mechanisms remain elusive, and treatment is not satisfactory. Systemic chronic inflammation (SCI) that we are referring to in this perspective is a state of low-grade, persistent, non-infective inflammation, being found in many physiological and pathological conditions. Distinct from acute inflammation, which is a protective process fighting against intruders, SCI might have harmful effects. It has been associated with many chronic non-communicable diseases. We hypothesize that SCI could be a predisposing and/or precipitating factor in the development of chronic pain, as well as associated comorbidities. We reviewed evidence from human clinical studies indicating the coexistence of SCI with various types of chronic pain. We also collated existing data about the sources of SCI and who could have it, showing that those individuals or patients having SCI usually have higher prevalence of chronic pain and psychological comorbidities. We thus elaborate on the need for further research in the connection between SCI and chronic pain. Several hypotheses have been proposed to explain these complex interactions.
format	article
author	Wen Bo Sam Zhou Wen Bo Sam Zhou JingWen Meng JingWen Meng Ji Zhang Ji Zhang Ji Zhang
author_facet	Wen Bo Sam Zhou Wen Bo Sam Zhou JingWen Meng JingWen Meng Ji Zhang Ji Zhang Ji Zhang
author_sort	Wen Bo Sam Zhou
title	Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?
title_short	Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?
title_full	Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?
title_fullStr	Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?
title_full_unstemmed	Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?
title_sort	does low grade systemic inflammation have a role in chronic pain?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/09aed24c44ce45ce839586318738e9ba
work_keys_str_mv	AT wenbosamzhou doeslowgradesystemicinflammationhavearoleinchronicpain AT wenbosamzhou doeslowgradesystemicinflammationhavearoleinchronicpain AT jingwenmeng doeslowgradesystemicinflammationhavearoleinchronicpain AT jingwenmeng doeslowgradesystemicinflammationhavearoleinchronicpain AT jizhang doeslowgradesystemicinflammationhavearoleinchronicpain AT jizhang doeslowgradesystemicinflammationhavearoleinchronicpain AT jizhang doeslowgradesystemicinflammationhavearoleinchronicpain
_version_	1718440346554204160

Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?

Ejemplares similares