Long-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosis

Abstract Vaccination of goats against tuberculosis (TB) has been promoted as an ancillary tool for controlling the disease in infected livestock herds. A three-year trial to assess the efficacy of BCG vaccine was carried out in five goat herds. At the beginning of the trial (month 0), all animals we...

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Autores principales:	Claudia Arrieta-Villegas, Alberto Allepuz, Miriam Grasa, Maite Martín, Zoraida Cervera, Irene Mercader, Sergio López-Soria, Mariano Domingo, Bernat Pérez de Val
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/09af506ae2014901a4f600ebd84dce56
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spelling	oai:doaj.org-article:09af506ae2014901a4f600ebd84dce562021-12-02T11:42:15ZLong-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosis10.1038/s41598-020-77334-12045-2322https://doaj.org/article/09af506ae2014901a4f600ebd84dce562020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77334-1https://doaj.org/toc/2045-2322Abstract Vaccination of goats against tuberculosis (TB) has been promoted as an ancillary tool for controlling the disease in infected livestock herds. A three-year trial to assess the efficacy of BCG vaccine was carried out in five goat herds. At the beginning of the trial (month 0), all animals were tested for TB using thee different diagnostic tests. Animals negative to all tests were vaccinated with BCG and all replacement goat kids were also systematically vaccinated throughout the trial. All animals were tested by Interferon-gamma release assay (IGRA) using vaccine compatible reagents at months 6, 12, 24, and 36. The risk factors for TB infection were also evaluated. At the end of the study, four out of five farms showed variable reductions of the initial prevalence (93.5%, 28.5%, 23.2%, and 14.3% respectively), and an overall incidence reduction of 50% was observed in BCG vaccinated goats, although adult vaccinated goats showed higher incidences than vaccinated goat kids. The unvaccinated positive animals remaining in herds and adult BCG vaccinated goats significantly enhanced the risk of infection in vaccinated animals. A systematic vaccination of goats with BCG, together with the removal of positive unvaccinated animals, may contribute to reducing the TB prevalence in goat herds.Claudia Arrieta-VillegasAlberto AllepuzMiriam GrasaMaite MartínZoraida CerveraIrene MercaderSergio López-SoriaMariano DomingoBernat Pérez de ValNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Claudia Arrieta-Villegas Alberto Allepuz Miriam Grasa Maite Martín Zoraida Cervera Irene Mercader Sergio López-Soria Mariano Domingo Bernat Pérez de Val Long-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosis
description	Abstract Vaccination of goats against tuberculosis (TB) has been promoted as an ancillary tool for controlling the disease in infected livestock herds. A three-year trial to assess the efficacy of BCG vaccine was carried out in five goat herds. At the beginning of the trial (month 0), all animals were tested for TB using thee different diagnostic tests. Animals negative to all tests were vaccinated with BCG and all replacement goat kids were also systematically vaccinated throughout the trial. All animals were tested by Interferon-gamma release assay (IGRA) using vaccine compatible reagents at months 6, 12, 24, and 36. The risk factors for TB infection were also evaluated. At the end of the study, four out of five farms showed variable reductions of the initial prevalence (93.5%, 28.5%, 23.2%, and 14.3% respectively), and an overall incidence reduction of 50% was observed in BCG vaccinated goats, although adult vaccinated goats showed higher incidences than vaccinated goat kids. The unvaccinated positive animals remaining in herds and adult BCG vaccinated goats significantly enhanced the risk of infection in vaccinated animals. A systematic vaccination of goats with BCG, together with the removal of positive unvaccinated animals, may contribute to reducing the TB prevalence in goat herds.
format	article
author	Claudia Arrieta-Villegas Alberto Allepuz Miriam Grasa Maite Martín Zoraida Cervera Irene Mercader Sergio López-Soria Mariano Domingo Bernat Pérez de Val
author_facet	Claudia Arrieta-Villegas Alberto Allepuz Miriam Grasa Maite Martín Zoraida Cervera Irene Mercader Sergio López-Soria Mariano Domingo Bernat Pérez de Val
author_sort	Claudia Arrieta-Villegas
title	Long-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosis
title_short	Long-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosis
title_full	Long-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosis
title_fullStr	Long-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosis
title_full_unstemmed	Long-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosis
title_sort	long-term efficacy of bcg vaccination in goat herds with a high prevalence of tuberculosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/09af506ae2014901a4f600ebd84dce56
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Long-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosis

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