Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice

Fields et al. investigate the impact of vitamin B6 deficiency on islet β-cell proliferation during pregnancy, using vitamin B6-deficient mice. They find that gestational vitamin B6 deficiency decreases serotonin levels in pancreatic islets and reduces β-cell proliferation, showing that vitamin B6 de...

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Autores principales:	Ashley M. Fields, Kevin Welle, Elaine S. Ho, Clementina Mesaros, Martha Susiarjo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/09af5f83b4974b0d925a99ec862ef581
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spelling	oai:doaj.org-article:09af5f83b4974b0d925a99ec862ef5812021-12-02T11:44:59ZVitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice10.1038/s42003-021-01900-02399-3642https://doaj.org/article/09af5f83b4974b0d925a99ec862ef5812021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01900-0https://doaj.org/toc/2399-3642Fields et al. investigate the impact of vitamin B6 deficiency on islet β-cell proliferation during pregnancy, using vitamin B6-deficient mice. They find that gestational vitamin B6 deficiency decreases serotonin levels in pancreatic islets and reduces β-cell proliferation, showing that vitamin B6 deficiency regulates maternal glucose tolerance in a serotonin-dependent manner.Ashley M. FieldsKevin WelleElaine S. HoClementina MesarosMartha SusiarjoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ashley M. Fields Kevin Welle Elaine S. Ho Clementina Mesaros Martha Susiarjo Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
description	Fields et al. investigate the impact of vitamin B6 deficiency on islet β-cell proliferation during pregnancy, using vitamin B6-deficient mice. They find that gestational vitamin B6 deficiency decreases serotonin levels in pancreatic islets and reduces β-cell proliferation, showing that vitamin B6 deficiency regulates maternal glucose tolerance in a serotonin-dependent manner.
format	article
author	Ashley M. Fields Kevin Welle Elaine S. Ho Clementina Mesaros Martha Susiarjo
author_facet	Ashley M. Fields Kevin Welle Elaine S. Ho Clementina Mesaros Martha Susiarjo
author_sort	Ashley M. Fields
title	Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
title_short	Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
title_full	Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
title_fullStr	Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
title_full_unstemmed	Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
title_sort	vitamin b6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/09af5f83b4974b0d925a99ec862ef581
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Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice

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