Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics

Kistamicin is a structurally divergent glycopeptide antibiotic (GPA) that contains a unique 15-membered A-O-B ring. Here, the authors obtained a crystal structure of the kistamicin OxyA/X-domain complex and analysed the cyclisation cascade leading to the formation of the A-O-B ring.

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Autores principales:	Anja Greule, Thierry Izoré, Dumitrita Iftime, Julien Tailhades, Melanie Schoppet, Yongwei Zhao, Madeleine Peschke, Iftekhar Ahmed, Andreas Kulik, Martina Adamek, Robert J. A. Goode, Ralf B. Schittenhelm, Joe A. Kaczmarski, Colin J. Jackson, Nadine Ziemert, Elizabeth H. Krenske, James J. De Voss, Evi Stegmann, Max J. Cryle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/09b465696c784ff3b63bbdc04e4fd0ff
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spelling	oai:doaj.org-article:09b465696c784ff3b63bbdc04e4fd0ff2021-12-02T14:40:18ZKistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics10.1038/s41467-019-10384-w2041-1723https://doaj.org/article/09b465696c784ff3b63bbdc04e4fd0ff2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10384-whttps://doaj.org/toc/2041-1723Kistamicin is a structurally divergent glycopeptide antibiotic (GPA) that contains a unique 15-membered A-O-B ring. Here, the authors obtained a crystal structure of the kistamicin OxyA/X-domain complex and analysed the cyclisation cascade leading to the formation of the A-O-B ring.Anja GreuleThierry IzoréDumitrita IftimeJulien TailhadesMelanie SchoppetYongwei ZhaoMadeleine PeschkeIftekhar AhmedAndreas KulikMartina AdamekRobert J. A. GoodeRalf B. SchittenhelmJoe A. KaczmarskiColin J. JacksonNadine ZiemertElizabeth H. KrenskeJames J. De VossEvi StegmannMax J. CryleNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anja Greule Thierry Izoré Dumitrita Iftime Julien Tailhades Melanie Schoppet Yongwei Zhao Madeleine Peschke Iftekhar Ahmed Andreas Kulik Martina Adamek Robert J. A. Goode Ralf B. Schittenhelm Joe A. Kaczmarski Colin J. Jackson Nadine Ziemert Elizabeth H. Krenske James J. De Voss Evi Stegmann Max J. Cryle Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics
description	Kistamicin is a structurally divergent glycopeptide antibiotic (GPA) that contains a unique 15-membered A-O-B ring. Here, the authors obtained a crystal structure of the kistamicin OxyA/X-domain complex and analysed the cyclisation cascade leading to the formation of the A-O-B ring.
format	article
author	Anja Greule Thierry Izoré Dumitrita Iftime Julien Tailhades Melanie Schoppet Yongwei Zhao Madeleine Peschke Iftekhar Ahmed Andreas Kulik Martina Adamek Robert J. A. Goode Ralf B. Schittenhelm Joe A. Kaczmarski Colin J. Jackson Nadine Ziemert Elizabeth H. Krenske James J. De Voss Evi Stegmann Max J. Cryle
author_facet	Anja Greule Thierry Izoré Dumitrita Iftime Julien Tailhades Melanie Schoppet Yongwei Zhao Madeleine Peschke Iftekhar Ahmed Andreas Kulik Martina Adamek Robert J. A. Goode Ralf B. Schittenhelm Joe A. Kaczmarski Colin J. Jackson Nadine Ziemert Elizabeth H. Krenske James J. De Voss Evi Stegmann Max J. Cryle
author_sort	Anja Greule
title	Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics
title_short	Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics
title_full	Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics
title_fullStr	Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics
title_full_unstemmed	Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics
title_sort	kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/09b465696c784ff3b63bbdc04e4fd0ff
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Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics

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