ASSOCIATION OF STEROID RECEPTOR EXPRESSION WITH THE CLINICAL AND HISTOLOGICAL FINDINGS IN PATIENTS WITH ENDOMETRIAL CANCER

Objective: To determine the association of estrogen and progesterone receptor expression with the clinical and histological findings of endometrial cancer. Study Design: Prospective observational study. Place and Duration of Study: Jinnah Postgraduate Medical Centre, Karachi between Sep 2017 t...

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Autores principales:	Aisha Shahid, Ghulam Haider, Paras Memon, Shumyla Beg, Mehwish Shahzadi, Kiran Abbas
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	er expression endometrial carcinoma pr expression endometrioid cancer estrogen Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/09b696c9a7a84cb99edad6d2e60b0b98
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spelling	oai:doaj.org-article:09b696c9a7a84cb99edad6d2e60b0b982021-11-25T02:42:55ZASSOCIATION OF STEROID RECEPTOR EXPRESSION WITH THE CLINICAL AND HISTOLOGICAL FINDINGS IN PATIENTS WITH ENDOMETRIAL CANCER0030-96482411-8842https://doaj.org/article/09b696c9a7a84cb99edad6d2e60b0b982021-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/5802/3641https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the association of estrogen and progesterone receptor expression with the clinical and histological findings of endometrial cancer. Study Design: Prospective observational study. Place and Duration of Study: Jinnah Postgraduate Medical Centre, Karachi between Sep 2017 to Oct 2019. Methodology: A total of 130 patients were diagnosed with endometrial carcinoma. Data from patient files were collected regarding tumour histology, grade, stage, tumour receptor expression, and the clinical characteristics: parity, menopausal status. The receptor expression profile was documented for each patient. Data were analyzed using SPSS version 25. The association between ER/PR expression categories and clinical/histological features were explored using the chi-square test. Results: The estrogen and progesterone receptor expressions were significantly associated with low-grade (Grade I and II) tumours and with Stage I and Stage II endometrial carcinoma with p<0.001. About 34 (34.7%) cases of endometrioid histology were negative for both estrogen and progesterone receptors. The ER and PR negativity was strongly associated with Grade III endometrial cancer (p=0.003). The majority of the stage IV cancers were negative for both the ER and PR receptors with a p<0.001. Conclusion: Estrogen and progesterone positivity was associated with endometrioid adenocarcinoma, well-differentiated, and less advanced stage of endometrial cancer at the time of diagnosis.Aisha ShahidGhulam HaiderParas MemonShumyla BegMehwish ShahzadiKiran AbbasArmy Medical College Rawalpindiarticleer expressionendometrial carcinomapr expressionendometrioid cancerestrogenMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 5, Pp 1875-1879 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	er expression endometrial carcinoma pr expression endometrioid cancer estrogen Medicine R Medicine (General) R5-920
spellingShingle	er expression endometrial carcinoma pr expression endometrioid cancer estrogen Medicine R Medicine (General) R5-920 Aisha Shahid Ghulam Haider Paras Memon Shumyla Beg Mehwish Shahzadi Kiran Abbas ASSOCIATION OF STEROID RECEPTOR EXPRESSION WITH THE CLINICAL AND HISTOLOGICAL FINDINGS IN PATIENTS WITH ENDOMETRIAL CANCER
description	Objective: To determine the association of estrogen and progesterone receptor expression with the clinical and histological findings of endometrial cancer. Study Design: Prospective observational study. Place and Duration of Study: Jinnah Postgraduate Medical Centre, Karachi between Sep 2017 to Oct 2019. Methodology: A total of 130 patients were diagnosed with endometrial carcinoma. Data from patient files were collected regarding tumour histology, grade, stage, tumour receptor expression, and the clinical characteristics: parity, menopausal status. The receptor expression profile was documented for each patient. Data were analyzed using SPSS version 25. The association between ER/PR expression categories and clinical/histological features were explored using the chi-square test. Results: The estrogen and progesterone receptor expressions were significantly associated with low-grade (Grade I and II) tumours and with Stage I and Stage II endometrial carcinoma with p<0.001. About 34 (34.7%) cases of endometrioid histology were negative for both estrogen and progesterone receptors. The ER and PR negativity was strongly associated with Grade III endometrial cancer (p=0.003). The majority of the stage IV cancers were negative for both the ER and PR receptors with a p<0.001. Conclusion: Estrogen and progesterone positivity was associated with endometrioid adenocarcinoma, well-differentiated, and less advanced stage of endometrial cancer at the time of diagnosis.
format	article
author	Aisha Shahid Ghulam Haider Paras Memon Shumyla Beg Mehwish Shahzadi Kiran Abbas
author_facet	Aisha Shahid Ghulam Haider Paras Memon Shumyla Beg Mehwish Shahzadi Kiran Abbas
author_sort	Aisha Shahid
title	ASSOCIATION OF STEROID RECEPTOR EXPRESSION WITH THE CLINICAL AND HISTOLOGICAL FINDINGS IN PATIENTS WITH ENDOMETRIAL CANCER
title_short	ASSOCIATION OF STEROID RECEPTOR EXPRESSION WITH THE CLINICAL AND HISTOLOGICAL FINDINGS IN PATIENTS WITH ENDOMETRIAL CANCER
title_full	ASSOCIATION OF STEROID RECEPTOR EXPRESSION WITH THE CLINICAL AND HISTOLOGICAL FINDINGS IN PATIENTS WITH ENDOMETRIAL CANCER
title_fullStr	ASSOCIATION OF STEROID RECEPTOR EXPRESSION WITH THE CLINICAL AND HISTOLOGICAL FINDINGS IN PATIENTS WITH ENDOMETRIAL CANCER
title_full_unstemmed	ASSOCIATION OF STEROID RECEPTOR EXPRESSION WITH THE CLINICAL AND HISTOLOGICAL FINDINGS IN PATIENTS WITH ENDOMETRIAL CANCER
title_sort	association of steroid receptor expression with the clinical and histological findings in patients with endometrial cancer
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/09b696c9a7a84cb99edad6d2e60b0b98
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ASSOCIATION OF STEROID RECEPTOR EXPRESSION WITH THE CLINICAL AND HISTOLOGICAL FINDINGS IN PATIENTS WITH ENDOMETRIAL CANCER

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