Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

RIPK1 kinase activity is known to transduce a death signal, but the molecular mechanisms that normally prevent RIPK1 activation are unclear. Here, the authors report that IKK-mediated phosphorylation on RIPK1 Ser25 directly represses its enzymatic activity and thus RIPK1-dependent cell death.

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Autores principales:	Yves Dondelinger, Tom Delanghe, Dario Priem, Meghan A. Wynosky-Dolfi, Daniel Sorobetea, Diego Rojas-Rivera, Piero Giansanti, Ria Roelandt, Julia Gropengiesser, Klaus Ruckdeschel, Savvas N. Savvides, Albert J. R. Heck, Peter Vandenabeele, Igor E. Brodsky, Mathieu J. M. Bertrand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/09b6a96e862a47278fdf07e7af978602
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spelling	oai:doaj.org-article:09b6a96e862a47278fdf07e7af9786022021-12-02T14:39:18ZSerine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation10.1038/s41467-019-09690-02041-1723https://doaj.org/article/09b6a96e862a47278fdf07e7af9786022019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09690-0https://doaj.org/toc/2041-1723RIPK1 kinase activity is known to transduce a death signal, but the molecular mechanisms that normally prevent RIPK1 activation are unclear. Here, the authors report that IKK-mediated phosphorylation on RIPK1 Ser25 directly represses its enzymatic activity and thus RIPK1-dependent cell death.Yves DondelingerTom DelangheDario PriemMeghan A. Wynosky-DolfiDaniel SorobeteaDiego Rojas-RiveraPiero GiansantiRia RoelandtJulia GropengiesserKlaus RuckdeschelSavvas N. SavvidesAlbert J. R. HeckPeter VandenabeeleIgor E. BrodskyMathieu J. M. BertrandNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yves Dondelinger Tom Delanghe Dario Priem Meghan A. Wynosky-Dolfi Daniel Sorobetea Diego Rojas-Rivera Piero Giansanti Ria Roelandt Julia Gropengiesser Klaus Ruckdeschel Savvas N. Savvides Albert J. R. Heck Peter Vandenabeele Igor E. Brodsky Mathieu J. M. Bertrand Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
description	RIPK1 kinase activity is known to transduce a death signal, but the molecular mechanisms that normally prevent RIPK1 activation are unclear. Here, the authors report that IKK-mediated phosphorylation on RIPK1 Ser25 directly represses its enzymatic activity and thus RIPK1-dependent cell death.
format	article
author	Yves Dondelinger Tom Delanghe Dario Priem Meghan A. Wynosky-Dolfi Daniel Sorobetea Diego Rojas-Rivera Piero Giansanti Ria Roelandt Julia Gropengiesser Klaus Ruckdeschel Savvas N. Savvides Albert J. R. Heck Peter Vandenabeele Igor E. Brodsky Mathieu J. M. Bertrand
author_facet	Yves Dondelinger Tom Delanghe Dario Priem Meghan A. Wynosky-Dolfi Daniel Sorobetea Diego Rojas-Rivera Piero Giansanti Ria Roelandt Julia Gropengiesser Klaus Ruckdeschel Savvas N. Savvides Albert J. R. Heck Peter Vandenabeele Igor E. Brodsky Mathieu J. M. Bertrand
author_sort	Yves Dondelinger
title	Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
title_short	Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
title_full	Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
title_fullStr	Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
title_full_unstemmed	Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
title_sort	serine 25 phosphorylation inhibits ripk1 kinase-dependent cell death in models of infection and inflammation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/09b6a96e862a47278fdf07e7af978602
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Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

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