Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study
Abstract This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with ov...
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Nature Portfolio
2018
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oai:doaj.org-article:09b7db9ce7dd46a9907e79b14afa08f12021-12-02T15:08:54ZType 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study10.1038/s41598-018-33843-82045-2322https://doaj.org/article/09b7db9ce7dd46a9907e79b14afa08f12018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33843-8https://doaj.org/toc/2045-2322Abstract This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration was associated with worse performance in EF. Participants with type 2 diabetes and HbA1c<53 mmol/mol displayed better cognitive performance when compared to those with HbA1c≥53 mmol/mol. Our results provide a controlled comprehensive model that integrates relevant neuropsychological and physical variables in type 2 diabetes. The model suggests that, to improve treatment adherence and quality of life once diabetes has been diagnosed, cognitive decline prevention strategies need to be implemented while monitoring depressive symptoms, BMI and glycaemia control.Núria Mallorquí-BaguéMaría Lozano-MadridEstefanía ToledoDolores CorellaJordi Salas-SalvadóAida Cuenca-RoyoJesús VioqueDora RomagueraJ. Alfredo MartínezJulia WärnbergJosé López-MirandaRamón EstruchAurora Bueno-CavanillasÁngel Alonso-GómezJosep A. TurFrancisco J. TinahonesLluís Serra-MajemVicente MartínJosé LapetraClotilde VázquezXavier PintóJosep VidalLidia DaimielJosé J. GaforioPilar MatíaEmilio RosRoser GraneroPilar Buil-CosialesRocío BarragánMònica BullóOlga CastañerManoli García-de-la-HeraAina M. YáñezItziar AbeteAntonio García-RíosMiguel Ruiz-CanelaAndrés Díaz-LópezSusana Jiménez-MurciaMiguel A. Martínez-GonzálezRafael De la TorreFernando Fernández-ArandaNature PortfolioarticleBaseline Cross-sectional AnalysisGlycaemic ControlDiabetes Treatment AdherenceApnoeaCognitive Function PerformanceMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) |
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Baseline Cross-sectional Analysis Glycaemic Control Diabetes Treatment Adherence Apnoea Cognitive Function Performance Medicine R Science Q |
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Baseline Cross-sectional Analysis Glycaemic Control Diabetes Treatment Adherence Apnoea Cognitive Function Performance Medicine R Science Q Núria Mallorquí-Bagué María Lozano-Madrid Estefanía Toledo Dolores Corella Jordi Salas-Salvadó Aida Cuenca-Royo Jesús Vioque Dora Romaguera J. Alfredo Martínez Julia Wärnberg José López-Miranda Ramón Estruch Aurora Bueno-Cavanillas Ángel Alonso-Gómez Josep A. Tur Francisco J. Tinahones Lluís Serra-Majem Vicente Martín José Lapetra Clotilde Vázquez Xavier Pintó Josep Vidal Lidia Daimiel José J. Gaforio Pilar Matía Emilio Ros Roser Granero Pilar Buil-Cosiales Rocío Barragán Mònica Bulló Olga Castañer Manoli García-de-la-Hera Aina M. Yáñez Itziar Abete Antonio García-Ríos Miguel Ruiz-Canela Andrés Díaz-López Susana Jiménez-Murcia Miguel A. Martínez-González Rafael De la Torre Fernando Fernández-Aranda Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study |
| description |
Abstract This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration was associated with worse performance in EF. Participants with type 2 diabetes and HbA1c<53 mmol/mol displayed better cognitive performance when compared to those with HbA1c≥53 mmol/mol. Our results provide a controlled comprehensive model that integrates relevant neuropsychological and physical variables in type 2 diabetes. The model suggests that, to improve treatment adherence and quality of life once diabetes has been diagnosed, cognitive decline prevention strategies need to be implemented while monitoring depressive symptoms, BMI and glycaemia control. |
| format |
article |
| author |
Núria Mallorquí-Bagué María Lozano-Madrid Estefanía Toledo Dolores Corella Jordi Salas-Salvadó Aida Cuenca-Royo Jesús Vioque Dora Romaguera J. Alfredo Martínez Julia Wärnberg José López-Miranda Ramón Estruch Aurora Bueno-Cavanillas Ángel Alonso-Gómez Josep A. Tur Francisco J. Tinahones Lluís Serra-Majem Vicente Martín José Lapetra Clotilde Vázquez Xavier Pintó Josep Vidal Lidia Daimiel José J. Gaforio Pilar Matía Emilio Ros Roser Granero Pilar Buil-Cosiales Rocío Barragán Mònica Bulló Olga Castañer Manoli García-de-la-Hera Aina M. Yáñez Itziar Abete Antonio García-Ríos Miguel Ruiz-Canela Andrés Díaz-López Susana Jiménez-Murcia Miguel A. Martínez-González Rafael De la Torre Fernando Fernández-Aranda |
| author_facet |
Núria Mallorquí-Bagué María Lozano-Madrid Estefanía Toledo Dolores Corella Jordi Salas-Salvadó Aida Cuenca-Royo Jesús Vioque Dora Romaguera J. Alfredo Martínez Julia Wärnberg José López-Miranda Ramón Estruch Aurora Bueno-Cavanillas Ángel Alonso-Gómez Josep A. Tur Francisco J. Tinahones Lluís Serra-Majem Vicente Martín José Lapetra Clotilde Vázquez Xavier Pintó Josep Vidal Lidia Daimiel José J. Gaforio Pilar Matía Emilio Ros Roser Granero Pilar Buil-Cosiales Rocío Barragán Mònica Bulló Olga Castañer Manoli García-de-la-Hera Aina M. Yáñez Itziar Abete Antonio García-Ríos Miguel Ruiz-Canela Andrés Díaz-López Susana Jiménez-Murcia Miguel A. Martínez-González Rafael De la Torre Fernando Fernández-Aranda |
| author_sort |
Núria Mallorquí-Bagué |
| title |
Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study |
| title_short |
Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study |
| title_full |
Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study |
| title_fullStr |
Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study |
| title_full_unstemmed |
Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study |
| title_sort |
type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the predimed-plus study |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/09b7db9ce7dd46a9907e79b14afa08f1 |
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