The Role of QuantiFERON-TB Gold Plus in Mycobacterium Tuberculosis Detection in a Severe HIV Immunocompromised Patient—Case Report

Tuberculosis (TB) is an important opportunistic infection in HIV-positive people. We are reporting a case of a 31-year-old HIV-infected patient who was hospitalized in July 2021 for dyspnea, cough with mucopurulent sputum and asthenia. He was confirmed to have Serratia liquefaciens pneumonia and acu...

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Autores principales:	Florentina Dumitrescu, Cătălina-Gabriela Pisoschi, Vlad Pădureanu, Andreea Cristina Stoian, Livia Dragonu, Lucian Giubelan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	HIV tuberculosis infection QuantiFERON-TB Medicine R
Acceso en línea:	https://doaj.org/article/09b8523ed86e4938ac54e72a09eab76c
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spelling	oai:doaj.org-article:09b8523ed86e4938ac54e72a09eab76c2021-11-25T18:38:55ZThe Role of QuantiFERON-TB Gold Plus in Mycobacterium Tuberculosis Detection in a Severe HIV Immunocompromised Patient—Case Report10.3390/pathogens101115232076-0817https://doaj.org/article/09b8523ed86e4938ac54e72a09eab76c2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1523https://doaj.org/toc/2076-0817Tuberculosis (TB) is an important opportunistic infection in HIV-positive people. We are reporting a case of a 31-year-old HIV-infected patient who was hospitalized in July 2021 for dyspnea, cough with mucopurulent sputum and asthenia. He was confirmed to have Serratia liquefaciens pneumonia and acute respiratory failure. The evolution was unfavorable despite the antibiotic, pathogenic and symptomatic treatment. Because the patient had severe immunosuppression (CD4 count = 37 cell/mm<sup>3</sup>), we used QuantiFERON-TB Gold Plus for the detection of the Mycobacterium tuberculosis infection. The antituberculosis therapy was initiated, which resulted in a significant improvement of the general condition and the patient was discharged with the recommendation to continue antiretroviral therapy, antituberculosis treatment and Trimethoprim/Sulfamethoxazole—single tablet daily for the prophylaxis of Pneumocystis pneumonia.Florentina DumitrescuCătălina-Gabriela PisoschiVlad PădureanuAndreea Cristina StoianLivia DragonuLucian GiubelanMDPI AGarticleHIVtuberculosisinfectionQuantiFERON-TBMedicineRENPathogens, Vol 10, Iss 1523, p 1523 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HIV tuberculosis infection QuantiFERON-TB Medicine R
spellingShingle	HIV tuberculosis infection QuantiFERON-TB Medicine R Florentina Dumitrescu Cătălina-Gabriela Pisoschi Vlad Pădureanu Andreea Cristina Stoian Livia Dragonu Lucian Giubelan The Role of QuantiFERON-TB Gold Plus in Mycobacterium Tuberculosis Detection in a Severe HIV Immunocompromised Patient—Case Report
description	Tuberculosis (TB) is an important opportunistic infection in HIV-positive people. We are reporting a case of a 31-year-old HIV-infected patient who was hospitalized in July 2021 for dyspnea, cough with mucopurulent sputum and asthenia. He was confirmed to have Serratia liquefaciens pneumonia and acute respiratory failure. The evolution was unfavorable despite the antibiotic, pathogenic and symptomatic treatment. Because the patient had severe immunosuppression (CD4 count = 37 cell/mm<sup>3</sup>), we used QuantiFERON-TB Gold Plus for the detection of the Mycobacterium tuberculosis infection. The antituberculosis therapy was initiated, which resulted in a significant improvement of the general condition and the patient was discharged with the recommendation to continue antiretroviral therapy, antituberculosis treatment and Trimethoprim/Sulfamethoxazole—single tablet daily for the prophylaxis of Pneumocystis pneumonia.
format	article
author	Florentina Dumitrescu Cătălina-Gabriela Pisoschi Vlad Pădureanu Andreea Cristina Stoian Livia Dragonu Lucian Giubelan
author_facet	Florentina Dumitrescu Cătălina-Gabriela Pisoschi Vlad Pădureanu Andreea Cristina Stoian Livia Dragonu Lucian Giubelan
author_sort	Florentina Dumitrescu
title	The Role of QuantiFERON-TB Gold Plus in Mycobacterium Tuberculosis Detection in a Severe HIV Immunocompromised Patient—Case Report
title_short	The Role of QuantiFERON-TB Gold Plus in Mycobacterium Tuberculosis Detection in a Severe HIV Immunocompromised Patient—Case Report
title_full	The Role of QuantiFERON-TB Gold Plus in Mycobacterium Tuberculosis Detection in a Severe HIV Immunocompromised Patient—Case Report
title_fullStr	The Role of QuantiFERON-TB Gold Plus in Mycobacterium Tuberculosis Detection in a Severe HIV Immunocompromised Patient—Case Report
title_full_unstemmed	The Role of QuantiFERON-TB Gold Plus in Mycobacterium Tuberculosis Detection in a Severe HIV Immunocompromised Patient—Case Report
title_sort	role of quantiferon-tb gold plus in mycobacterium tuberculosis detection in a severe hiv immunocompromised patient—case report
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/09b8523ed86e4938ac54e72a09eab76c
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The Role of QuantiFERON-TB Gold Plus in Mycobacterium Tuberculosis Detection in a Severe HIV Immunocompromised Patient—Case Report

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