Atomic-scale insights into allosteric inhibition and evolutional rescue mechanism of Streptococcus thermophilus Cas9 by the anti-CRISPR protein AcrIIA6

Atomic-scale insights into allosteric inhibition and evolutional rescue mechanism of Streptococcus thermophilus Cas9 by the anti-CRISPR protein AcrIIA6

CRISPR-Cas systems are prokaryotic adaptive immunity against invading phages and plasmids. Phages have evolved diverse protein inhibitors of CRISPR-Cas systems, called anti-CRISPR (Acr) proteins, to neutralize this CRISPR machinery. In response, bacteria have co-evolved Cas variants to escape phage’...

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Bibliographic Details
Main Authors: Xinyi Li, Chengxiang Wang, Ting Peng, Zongtao Chai, Duan Ni, Yaqin Liu, Jian Zhang, Ting Chen, Shaoyong Lu
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
CRISPR-Cas
Anti-CRISPR proteins
Molecular dynamics simulations
Conformational dynamics
Gene editing
Biotechnology
TP248.13-248.65
Online Access:https://doaj.org/article/09b8e01bef4b459c82c24cad411db231
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