Macromolecular changes in spinal cord white matter characterize whiplash outcome at 1-year post motor vehicle collision

Abstract Each year, whiplash injuries from motor vehicle collisions (MVC) affect millions worldwide, with no strong evidence of pathology. While the majority recover soon after the injury, the same is not true for roughly 20% reporting higher levels of pain and distress, without diagnostic options....

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Autores principales:	Mark A. Hoggarth, James M. Elliott, Zachary A. Smith, Monica Paliwal, Mary J. Kwasny, Marie Wasielewski, Kenneth A. Weber, Todd B. Parrish
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/09b8ec8bc0da4e6193cc07aa0d0d86ab
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spelling	oai:doaj.org-article:09b8ec8bc0da4e6193cc07aa0d0d86ab2021-12-02T11:57:58ZMacromolecular changes in spinal cord white matter characterize whiplash outcome at 1-year post motor vehicle collision10.1038/s41598-020-79190-52045-2322https://doaj.org/article/09b8ec8bc0da4e6193cc07aa0d0d86ab2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79190-5https://doaj.org/toc/2045-2322Abstract Each year, whiplash injuries from motor vehicle collisions (MVC) affect millions worldwide, with no strong evidence of pathology. While the majority recover soon after the injury, the same is not true for roughly 20% reporting higher levels of pain and distress, without diagnostic options. This study used magnetization transfer (MT) imaging to quantify white matter integrity in 78 subjects with varying levels of pain, 1 year after MVC. MT images of the cervical spinal cord were collected parallel to the intervertebral disks. MT ratios (MTR) were calculated in select white matter tracts along with MTR homogeneity (MTRh) at each level. Significant differences were observed between clinical outcome groups in the left and right spinothalamic tracts (p = 0.003 and 0.020) and MTRh (p = 0.009). MTRh was elevated in females with poor recovery versus females reporting recovery (p < 0.001) or milder symptoms (p < 0.001), and in males reporting recovery (p = 0.007) or no recovery (p < 0.001). There was a significant interaction between recovery status and sex (p = 0.015). MT imaging identified tract specific and regional changes in white matter integrity suggesting potential insults to the cord. Additionally, significant MTRh differences between sexes were observed, characterizing the heterogeneity of whiplash recovery and worse outcomes in females.Mark A. HoggarthJames M. ElliottZachary A. SmithMonica PaliwalMary J. KwasnyMarie WasielewskiKenneth A. WeberTodd B. ParrishNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mark A. Hoggarth James M. Elliott Zachary A. Smith Monica Paliwal Mary J. Kwasny Marie Wasielewski Kenneth A. Weber Todd B. Parrish Macromolecular changes in spinal cord white matter characterize whiplash outcome at 1-year post motor vehicle collision
description	Abstract Each year, whiplash injuries from motor vehicle collisions (MVC) affect millions worldwide, with no strong evidence of pathology. While the majority recover soon after the injury, the same is not true for roughly 20% reporting higher levels of pain and distress, without diagnostic options. This study used magnetization transfer (MT) imaging to quantify white matter integrity in 78 subjects with varying levels of pain, 1 year after MVC. MT images of the cervical spinal cord were collected parallel to the intervertebral disks. MT ratios (MTR) were calculated in select white matter tracts along with MTR homogeneity (MTRh) at each level. Significant differences were observed between clinical outcome groups in the left and right spinothalamic tracts (p = 0.003 and 0.020) and MTRh (p = 0.009). MTRh was elevated in females with poor recovery versus females reporting recovery (p < 0.001) or milder symptoms (p < 0.001), and in males reporting recovery (p = 0.007) or no recovery (p < 0.001). There was a significant interaction between recovery status and sex (p = 0.015). MT imaging identified tract specific and regional changes in white matter integrity suggesting potential insults to the cord. Additionally, significant MTRh differences between sexes were observed, characterizing the heterogeneity of whiplash recovery and worse outcomes in females.
format	article
author	Mark A. Hoggarth James M. Elliott Zachary A. Smith Monica Paliwal Mary J. Kwasny Marie Wasielewski Kenneth A. Weber Todd B. Parrish
author_facet	Mark A. Hoggarth James M. Elliott Zachary A. Smith Monica Paliwal Mary J. Kwasny Marie Wasielewski Kenneth A. Weber Todd B. Parrish
author_sort	Mark A. Hoggarth
title	Macromolecular changes in spinal cord white matter characterize whiplash outcome at 1-year post motor vehicle collision
title_short	Macromolecular changes in spinal cord white matter characterize whiplash outcome at 1-year post motor vehicle collision
title_full	Macromolecular changes in spinal cord white matter characterize whiplash outcome at 1-year post motor vehicle collision
title_fullStr	Macromolecular changes in spinal cord white matter characterize whiplash outcome at 1-year post motor vehicle collision
title_full_unstemmed	Macromolecular changes in spinal cord white matter characterize whiplash outcome at 1-year post motor vehicle collision
title_sort	macromolecular changes in spinal cord white matter characterize whiplash outcome at 1-year post motor vehicle collision
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/09b8ec8bc0da4e6193cc07aa0d0d86ab
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Macromolecular changes in spinal cord white matter characterize whiplash outcome at 1-year post motor vehicle collision

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