Studies on correlations between immunophenotype and the indices of metabolic enzyme activity of blood lymphocytes in children with hypertrophy of the pharyngeal tonsils

The objective of our study was to evaluate correlation between the immune pheno-type and activity indices of NAD (P)-dependent dehydrogenases in peripheral blood lymphocytes in young children with hypertrophy of the pharyngeal tonsil (HPT). We have examined 57 children, 1-3 years of age, with hypert...

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Autores principales:	L. M. Kurtasova, N. A. Shakina, T. V. Lubnina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2020
Materias:	pharyngeal tonsils hypertrophy lymphocytes phenotype enzymes correlation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/09bcbca954cb44d091167325540df20e
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spelling	oai:doaj.org-article:09bcbca954cb44d091167325540df20e2021-11-18T08:03:49ZStudies on correlations between immunophenotype and the indices of metabolic enzyme activity of blood lymphocytes in children with hypertrophy of the pharyngeal tonsils1563-06252313-741X10.15789/1563-0625-SOC-1806https://doaj.org/article/09bcbca954cb44d091167325540df20e2020-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1806https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe objective of our study was to evaluate correlation between the immune pheno-type and activity indices of NAD (P)-dependent dehydrogenases in peripheral blood lymphocytes in young children with hypertrophy of the pharyngeal tonsil (HPT). We have examined 57 children, 1-3 years of age, with hypertrophy of the pharyngeal tonsils (HPT). The control group consisted of 35 healthy children of the same age. The numbers of CD3+, CD4+, CD8+, CD19+, CD16+/56+ lymphoid cells in peripheral blood were determined by flow cytofluorimetry technique. Activity of NAD (P)-dependant dehydrogenases in peripheral blood lymphocytes was studied using bioluminescent method as described elsewhere (А. Savchenko, L. Suntsova, 1989). Correlation analysis has revealed an increase of positive correlations, a decrease of the correlation strength, and emergence of new connections between phenotype and activity indices of NAD (P)-dependent dehydrogenases in peripheral blood lymphocytes in children with hypertrophy of pharyngeal tonsils (HPT). Specific correlation patterns between the phenotype and activity indices of NAD (P)-dependent dehydrogenases in peripheral blood lymphocytes have been revealed in children with hypertrophy of pharyngeal tonsils (HPT).L. M. KurtasovaN. A. ShakinaT. V. LubninaSPb RAACIarticlepharyngeal tonsilshypertrophylymphocytesphenotypeenzymescorrelationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 22, Iss 1, Pp 165-170 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	pharyngeal tonsils hypertrophy lymphocytes phenotype enzymes correlation Immunologic diseases. Allergy RC581-607
spellingShingle	pharyngeal tonsils hypertrophy lymphocytes phenotype enzymes correlation Immunologic diseases. Allergy RC581-607 L. M. Kurtasova N. A. Shakina T. V. Lubnina Studies on correlations between immunophenotype and the indices of metabolic enzyme activity of blood lymphocytes in children with hypertrophy of the pharyngeal tonsils
description	The objective of our study was to evaluate correlation between the immune pheno-type and activity indices of NAD (P)-dependent dehydrogenases in peripheral blood lymphocytes in young children with hypertrophy of the pharyngeal tonsil (HPT). We have examined 57 children, 1-3 years of age, with hypertrophy of the pharyngeal tonsils (HPT). The control group consisted of 35 healthy children of the same age. The numbers of CD3+, CD4+, CD8+, CD19+, CD16+/56+ lymphoid cells in peripheral blood were determined by flow cytofluorimetry technique. Activity of NAD (P)-dependant dehydrogenases in peripheral blood lymphocytes was studied using bioluminescent method as described elsewhere (А. Savchenko, L. Suntsova, 1989). Correlation analysis has revealed an increase of positive correlations, a decrease of the correlation strength, and emergence of new connections between phenotype and activity indices of NAD (P)-dependent dehydrogenases in peripheral blood lymphocytes in children with hypertrophy of pharyngeal tonsils (HPT). Specific correlation patterns between the phenotype and activity indices of NAD (P)-dependent dehydrogenases in peripheral blood lymphocytes have been revealed in children with hypertrophy of pharyngeal tonsils (HPT).
format	article
author	L. M. Kurtasova N. A. Shakina T. V. Lubnina
author_facet	L. M. Kurtasova N. A. Shakina T. V. Lubnina
author_sort	L. M. Kurtasova
title	Studies on correlations between immunophenotype and the indices of metabolic enzyme activity of blood lymphocytes in children with hypertrophy of the pharyngeal tonsils
title_short	Studies on correlations between immunophenotype and the indices of metabolic enzyme activity of blood lymphocytes in children with hypertrophy of the pharyngeal tonsils
title_full	Studies on correlations between immunophenotype and the indices of metabolic enzyme activity of blood lymphocytes in children with hypertrophy of the pharyngeal tonsils
title_fullStr	Studies on correlations between immunophenotype and the indices of metabolic enzyme activity of blood lymphocytes in children with hypertrophy of the pharyngeal tonsils
title_full_unstemmed	Studies on correlations between immunophenotype and the indices of metabolic enzyme activity of blood lymphocytes in children with hypertrophy of the pharyngeal tonsils
title_sort	studies on correlations between immunophenotype and the indices of metabolic enzyme activity of blood lymphocytes in children with hypertrophy of the pharyngeal tonsils
publisher	SPb RAACI
publishDate	2020
url	https://doaj.org/article/09bcbca954cb44d091167325540df20e
work_keys_str_mv	AT lmkurtasova studiesoncorrelationsbetweenimmunophenotypeandtheindicesofmetabolicenzymeactivityofbloodlymphocytesinchildrenwithhypertrophyofthepharyngealtonsils AT nashakina studiesoncorrelationsbetweenimmunophenotypeandtheindicesofmetabolicenzymeactivityofbloodlymphocytesinchildrenwithhypertrophyofthepharyngealtonsils AT tvlubnina studiesoncorrelationsbetweenimmunophenotypeandtheindicesofmetabolicenzymeactivityofbloodlymphocytesinchildrenwithhypertrophyofthepharyngealtonsils
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Studies on correlations between immunophenotype and the indices of metabolic enzyme activity of blood lymphocytes in children with hypertrophy of the pharyngeal tonsils

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